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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

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About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Hidetoshi Masumoto

Research Leader
Hidetoshi Masumoto M.D., Ph.D.

iPS cell-based Cardiovascular Medical Research

LocationKobe / Developmental Biology Buildings

E-mailhidetoshi.masumoto[at]riken.jp

Please replace [at] with @.

Realization of healthy longevity through development of iPS cell-based cardiovascular medicine

With an aging society such as Japan, the frequency of cardiovascular diseases (diseases affecting the heart and blood vessels) is expected to progressively increase in the future. Heart transplantation is an ultimate therapeutic modality for severe heart failure, however, the availability of hearts for transplantation is quite limited. Thus, there is a need to develop new therapies for severe heart failure to be able to treat more heart patients. Our laboratory is working on discoveries for new cardiovascular medicine through iPS cell technology-based cardiac regenerative therapy and drug discovery research, drawing on our lab head’s clinical experiences as a cardiovascular surgeon to design an experimental plan addressing clinical needs and to conduct studies using surgically established cardiovascular disease animal models. Our goal is to realize the healthy longevity of humans through the development of iPS cell-based cardiovascular medicine.

We are also actively working together with many research institutes and industry partners to advance clinical translational medicine. We are currently working to prepare clinical research studies for cardiac regenerative therapy using human iPS cells in collaboration with Kyoto University and industry partners.

Bio-engineered cardiac tissue capable of self-contraction and comprising various human iPS cell-derived heart cell types.

Research Theme

  • Cardiovascular regenerative medicine and drug discovery using iPS cell-derived 3-dimensional heart tissues
  • iPS cell-derived heart organoid research
  • Recapitulation of heart function using iPS cell-based organ-on-a-chip (heart-on-a-chip)
  • Translational research through collaboration with academia and industry

Selected Publications

Murata K, Makino A, Tomonaga K, Masumoto H.
Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model. (※Cover image)
iScience 27(1), 108641 Fri Jan 19 00:00:00 JST 2024 doi: 10.1016/j.isci.2023.108641

Kyo S, Murata K, Kawatou M, et al.
Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.
JTCVS Open 12, 201-210 Thu Dec 01 00:00:00 JST 2022 doi: 10.1016/j.xjon.2022.11.001

Osada H, Kawatou M, Fujita D, et al.
Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues.
JTCVS Open 8, 359-374 Thu Nov 25 00:00:00 JST 2021 doi: 10.1016/j.xjon.2021.09.038

Abulaiti M, Yalikun Y, Murata K, et al.
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
Scientific Reports 10, 19201 Tue Dec 01 00:00:00 JST 2020 doi: 10.1038/s41598-020-76062-w

Ishigami M, Masumoto H, Ikuno T et al.
Human iPS Cell-Derived Cardiac Tissue Sheets for Functional Restoration of Infarcted Porcine Hearts.
PLoS One 13(8), e0201650 Sat Dec 01 00:00:00 JST 2018 doi: 10.1371/journal.pone.0201650

Takeda M, Kanki Y, Masumoto H et al.
Identification of Cardiomyocyte-Fated Progenitors From Human-Induced Pluripotent Stem Cells Marked With CD82.
Cell Reports 22(2), 546-556 Thu Nov 01 00:00:00 JST 2018 doi: 10.1016/j.celrep.2017.12.057

Kawatou M, Masumoto H, Fukushima H et al.
Modelling Torsade De Pointes Arrhythmias in Vitro in 3D Human iPS Cell-Engineered Heart Tissue.
Nature Communications 8(1), 1078 Fri Dec 01 00:00:00 JST 2017 doi: 10.1038/s41467-017-01125-y

Nakane T, Masumoto H, Tinney JP et al.
Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.
Scientific Reports 7, 45641 Wed Nov 01 00:00:00 JST 2017 doi: 10.1038/srep45641

Ikuno T, Masumoto H, Yamamizu K et al.
Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP.
PLoS One 12(4), e0176238 Sun Oct 01 00:00:00 JST 2017 doi: 10.1371/journal.pone.0176238

Masumoto H, Nakane T, Tinney JP et al.
The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages.
Scientific Reports 6, 29933 Thu Dec 01 00:00:00 JST 2016 doi: 10.1038/srep29933

Matsuo T, Masumoto H, Tajima S et al.
Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells.
Scientific Reports 5, 16842 Tue Dec 01 00:00:00 JST 2015 doi: 10.1038/srep16842

Masumoto H, Ikuno T, Takeda M et al.
Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.
Scientific Reports 4, 6716 Mon Dec 01 00:00:00 JST 2014 doi: 10.1038/srep06716

Masumoto H, Matsuo T, Yamamizu K et al.
Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization.
Stem Cells 30(6), 1196-1205 Sat Dec 01 00:00:00 JST 2012 doi: 10.1002/stem.1089

Members

Photo of Research Leader, Hidetoshi Masumoto

Research Leader /Senior ScientistHidetoshi Masumoto

  • hidetoshi.masumoto[at]riken.jp
    (Please replace [at] with @)
Photo of a member

Research ScientistKozue Murata

  • kozue.murata[at]riken.jp
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Postdoctoral ResearcherMosha Abulaiti

  • mosha.abulaiti[at]riken.jp
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Technical Staff IWusiman Maihemuti

  • wusiman.maihemuti[at]riken.jp
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Temporary StaffingKanae Takamura

  • kanae.takamura[at]riken.jp
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AssistantNaoko Ueda

  • naoko.ueda[at]riken.jp
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Student TraineeJun Iida

  • jun.iida[at]a.riken.jp
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Research Part-time Worker ILaura Yuriko González-Teshima

  • laurayuriko.teshima[at]riken.jp
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Student TraineeHenrika Ahola

  • henrika.ahola[at]a.riken.jp

(Please replace [at] with @)

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