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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

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Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

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Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

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News

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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Hidetoshi Masumoto

Research Leader
Hidetoshi Masumoto M.D., Ph.D.

LocationKobe / Developmental Biology Buildings

E-mailhidetoshi.masumoto[at]riken.jp

Please replace [at] with @.

Realization of healthy longevity through development of iPS cell-based cardiovascular medicine

With an aging society such as Japan, the frequency of cardiovascular diseases (diseases affecting the heart and blood vessels) is expected to progressively increase in the future. Heart transplantation is an ultimate therapeutic modality for severe heart failure, however, the availability of hearts for transplantation is quite limited. Thus, there is a need to develop new therapies for severe heart failure to be able to treat more heart patients. Our laboratory is working on discoveries for new cardiovascular medicine through iPS cell technology-based cardiac regenerative therapy and drug discovery research, drawing on our lab head’s clinical experiences as a cardiovascular surgeon to design an experimental plan addressing clinical needs and to conduct studies using surgically established cardiovascular disease animal models. Our goal is to realize the healthy longevity of humans through the development of iPS cell-based cardiovascular medicine.

We are also actively working together with many research institutes and industry partners to advance clinical translational medicine. We are currently working to prepare clinical research studies for cardiac regenerative therapy using human iPS cells in collaboration with Kyoto University and industry partners.

Bio-engineered cardiac tissue capable of self-contraction and comprising various human iPS cell-derived heart cell types.

Research Theme

  • Cardiovascular regenerative medicine and drug discovery using iPS cell-derived 3-dimensional heart tissues
  • iPS cell-derived heart organoid research
  • Recapitulation of heart function using iPS cell-based organ-on-a-chip (heart-on-a-chip)
  • Translational research through collaboration with academia and industry

Selected Publications

Osada H, Kawatou M, Fujita D, et al.
Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues.
JTCVS Open (2021) doi: 10.1016/j.xjon.2021.09.038

Abulaiti M, Yalikun Y, Murata K, et al.
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
Scientific Reports 10, 19201 (2020) doi: 10.1038/s41598-020-76062-w

Ishigami M, Masumoto H, Ikuno T et al.
Human iPS Cell-Derived Cardiac Tissue Sheets for Functional Restoration of Infarcted Porcine Hearts.
PLoS One 13(8), e0201650 (2018) doi: 10.1371/journal.pone.0201650

Takeda M, Kanki Y, Masumoto H et al.
Identification of Cardiomyocyte-Fated Progenitors From Human-Induced Pluripotent Stem Cells Marked With CD82.
Cell Reports 22(2), 546-556 (2018) doi: 10.1016/j.celrep.2017.12.057

Kawatou M, Masumoto H, Fukushima H et al.
Modelling Torsade De Pointes Arrhythmias in Vitro in 3D Human iPS Cell-Engineered Heart Tissue.
Nature Communications 8(1), 1078 (2017) doi: 10.1038/s41467-017-01125-y

Nakane T, Masumoto H, Tinney JP et al.
Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.
Scientific Reports 7, 45641 (2017) doi: 10.1038/srep45641

Ikuno T, Masumoto H, Yamamizu K et al.
Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP.
PLoS One 12(4), e0176238 (2017) doi: 10.1371/journal.pone.0176238

Masumoto H, Nakane T, Tinney JP et al.
The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages.
Scientific Reports 6, 29933 (2016) doi: 10.1038/srep29933

Matsuo T, Masumoto H, Tajima S et al.
Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells.
Scientific Reports 5, 16842 (2015) doi: 10.1038/srep16842

Masumoto H, Ikuno T, Takeda M et al.
Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.
Scientific Reports 4, 6716 (2014) doi: 10.1038/srep06716

Masumoto H, Matsuo T, Yamamizu K et al.
Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization.
Stem Cells 30(6), 1196-1205 (2012) doi: 10.1002/stem.1089

Members

Photo of Research Leader, Hidetoshi Masumoto

Research Leader /Senior ScientistHidetoshi Masumoto

  • hidetoshi.masumoto[at]riken.jp
    (Please replace [at] with @)
Photo of a member

Visiting ScientistKozue Murata

  • kozue.murata[at]riken.jp
Photo of a member

Research Part-time WorkerMosha Abulaiti

  • mosha.abulaiti[at]riken.jp
Photo of a member

Student TraineeMaihemuti Wusiman

  • wusiman.maihemuti[at]riken.jp
Photo of a member

Student TraineeJun Iida

  • jun.iida[at]a.riken.jp

(Please replace [at] with @)

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