チームリーダー
渡辺恭良 M.D., Ph.D.

健康・病態科学研究チーム

拠点神戸／MI R&Dセンタービル

E-mail yywata[at]riken.jp

[at]を@に変えてください

概要
主要論文
メンバー
ニュース

採用情報

パートタイマー募集（PHS2201）

—分子を活かす—動物の研究からヒトの研究へ橋渡しをします

がんなどの生活習慣病や認知症などの精神疾患では、症状が現れる前に生体分子の変化が生じ、病気の進行に伴ってその変化がさらに蓄積・変質していきます。このような分子の変化を発症に至る過程の源流で捉える、病態バイオマーカーイメージングの基盤技術を開発します。この技術により病態メカニズムを明らかにするとともに、疾患の診断や治療戦略の基盤となる情報を統合します。さらに、原因分子の異常を超早期に発見し先制医療に結びつけることや健康が損なわれる過程を定量化することで、医療イノベーションの礎を確立します。

研究テーマ

健康・未病バイオマーカーの創出と分子イメージングによる解析
病態進行バイオマーカーの創出と分子イメージングによる解析
健康科学・病態科学に根ざした製品開発の客観的イメージング指標の開発

主要論文

Zhang K, Sun Y, Wu S, et al.
Systematic imaging in medicine: a comprehensive review.
European journal of nuclear medicine and molecular imaging 48(6), 1736-1758 (2021) doi: 10.1007/s00259-020-05107-z

Watanabe Y, Mawatari A, Aita K, et al.
PET imaging of ¹¹C-labeled thiamine tetrahydrofurfuryl disulfide, vitamin B₁ derivative: First-in-human study.
Biochemical and biophysical research communications 555, 7-12 (2021) doi: 10.1016/j.bbrc.2021.03.119

Li D, Hu D, Shigeta M, et al.
Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.
Neuroscience research 165, 45-50 (2021) doi: 10.1016/j.neures.2020.04.005

Vong K, Tahara T, Urano S, et al.
Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.
Science advances 7(17), eabg4038 (2021) doi: 10.1126/sciadv.abg4038

Yamano E, Watanabe Y, Kataoka Y.
Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
International journal of molecular sciences 22(7), 3423 (2021) doi: 10.3390/ijms22073423

Hu D, Li D, Shigeta M, et al.
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
Biochemical and biophysical research communications 535, 1-5 (2021) doi: 10.1016/j.bbrc.2020.12.035

Watanabe Y.
PET/SPECT/MRI/fMRI Studies in the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
In: PET and SPECT in Psychiatry (Dierckx RAJO, Otte A, de Vries EFJ, wan Waarde A, Sommer IE, eds.) Springer, 985-1002 (2021)

Mukai H, Watanabe Y.
Review: PET imaging with macro- and middle-sized molecular probes.
Nuclear medicine and biology 92, 156-170 (2021) doi: 10.1016/j.nucmedbio.2020.06.007

Mizuno K, Ojiro D, Tanaka T, et al.
Relationship between truck driver fatigue and rear-end collision risk.
PloS one 15(9), e0238738 (2020) doi: 10.1371/journal.pone.0238738

Nomura S, Takahashi M, Kato AH, et al.
Biosorption-based ⁶⁴Cu-labeling of bacteria for pharmacokinetic positron-emission tomography.
International journal of pharmaceutics 590, 119950 (2020) doi: 10.1016/j.ijpharm.2020.119950

Kitami T, Fukuda S, Kato T, et al.
Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.
Scientific reports 10(1), 19933 (2020) doi: 10.1038/s41598-020-77105-y

Jonasson M, Nordeman P, Eriksson J, et al.
Quantification of aromatase binding in the female human brain using [¹¹ C]cetrozole positron emission tomography.
Journal of neuroscience research 98(11), 2208-2218 (2020) doi: 10.1002/jnr.24707

Smirnov I, Sibgatullina R, Urano S, et al.
A Strategy for Tumor Targeting by Higher-Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N-Glycan Molecules.
Small (Weinheim an der Bergstrasse, Germany) 16(46), e2004831 (2020) doi: 10.1002/smll.202004831

Kawano T, Naito J, Nishioka M, et al.
Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.
Nutrients 12(10), E3098 (2020) doi: 10.3390/nu12103098

Mizuno K, Sasaki AT, Watanabe K, Watanabe Y.
Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
Nutrients 12(6), E1640 (2020) doi: 10.3390/nu12061640

Nakaoka T, Uetake Y, Kaneko KI, et al.
Practical Synthesis of [¹⁸F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography.
Molecular pharmaceutics 17(6), 1884-1898 (2020) doi: 10.1021/acs.molpharmaceut.9b01284

Fukuchi T, Yamamoto S, Kataoka J, et al.
Beta-ray imaging system with γ-ray coincidence for multiple-tracer imaging.
Medical physics 47(2), 587-596 (2020) doi: 10.1002/mp.13947