BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.



BDR communicates the appeal and significance of our research to society through the use of various media and activities.



From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Yasuyoshi Watanabe

Team Leader
Yasuyoshi Watanabe M.D., Ph.D.

Laboratory for Pathophysiological and Health Science

[Closed Mar. 2023]


Please replace [at] with @.

―Utilizing Molecules― Translational study from animal to human

We provide core technologies to realize health sciences including very early diagnosis, pathophysiology, and preemptive medicine using imaging biomarkers closely related to disease state and pre-disease state (ahead sick), to innovate medical science with promotion of collaborations among all center members.

Research Theme

  • Molecular imaging study on newly developed biomarkers for evaluation of health and pre-disease state
  • Molecular imaging study on newly developed biomarkers for evaluation of disease state
  • Development of molecular imaging indices for products to avoid deterioration of health

Selected Publications

Fukuchi T, Niwa T, Hosoya T, Watanabe Y.
Computational Study for Amino Acid Production from Carboxylic Acid via 14C β-decay.
Journal of the Physical Society of Japan 91, 064301 (2022) doi: 10.7566/JPSJ.91.064301

Zhang K, Sun Y, Wu S, et al.
Systematic imaging in medicine: a comprehensive review.
European journal of nuclear medicine and molecular imaging 48(6), 1736-1758 (2021) doi: 10.1007/s00259-020-05107-z

Watanabe Y, Mawatari A, Aita K, et al.
PET imaging of 11C-labeled thiamine tetrahydrofurfuryl disulfide, vitamin B1 derivative: First-in-human study.
Biochemical and biophysical research communications 555, 7-12 (2021) doi: 10.1016/j.bbrc.2021.03.119

Li D, Hu D, Shigeta M, et al.
Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.
Neuroscience research 165, 45-50 (2021) doi: 10.1016/j.neures.2020.04.005

Vong K, Tahara T, Urano S, et al.
Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.
Science advances 7(17), eabg4038 (2021) doi: 10.1126/sciadv.abg4038

Yamano E, Watanabe Y, Kataoka Y.
Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
International journal of molecular sciences 22(7), 3423 (2021) doi: 10.3390/ijms22073423

Hu D, Li D, Shigeta M, et al.
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
Biochemical and biophysical research communications 535, 1-5 (2021) doi: 10.1016/j.bbrc.2020.12.035

Watanabe Y.
PET/SPECT/MRI/fMRI Studies in the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
In: PET and SPECT in Psychiatry (Dierckx RAJO, Otte A, de Vries EFJ, wan Waarde A, Sommer IE, eds.) Springer, 985-1002 (2021)

Mukai H, Watanabe Y.
Review: PET imaging with macro- and middle-sized molecular probes.
Nuclear medicine and biology 92, 156-170 (2021) doi: 10.1016/j.nucmedbio.2020.06.007

Mizuno K, Ojiro D, Tanaka T, et al.
Relationship between truck driver fatigue and rear-end collision risk.
PloS one 15(9), e0238738 (2020) doi: 10.1371/journal.pone.0238738

Nomura S, Takahashi M, Kato AH, et al.
Biosorption-based 64Cu-labeling of bacteria for pharmacokinetic positron-emission tomography.
International journal of pharmaceutics 590, 119950 (2020) doi: 10.1016/j.ijpharm.2020.119950

Kitami T, Fukuda S, Kato T, et al.
Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.
Scientific reports 10(1), 19933 (2020) doi: 10.1038/s41598-020-77105-y

Jonasson M, Nordeman P, Eriksson J, et al.
Quantification of aromatase binding in the female human brain using [11 C]cetrozole positron emission tomography.
Journal of neuroscience research 98(11), 2208-2218 (2020) doi: 10.1002/jnr.24707

Smirnov I, Sibgatullina R, Urano S, et al.
A Strategy for Tumor Targeting by Higher-Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N-Glycan Molecules.
Small (Weinheim an der Bergstrasse, Germany) 16(46), e2004831 (2020) doi: 10.1002/smll.202004831

Kawano T, Naito J, Nishioka M, et al.
Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.
Nutrients 12(10), E3098 (2020) doi: 10.3390/nu12103098

Mizuno K, Sasaki AT, Watanabe K, Watanabe Y.
Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
Nutrients 12(6), E1640 (2020) doi: 10.3390/nu12061640

Nakaoka T, Uetake Y, Kaneko KI, et al.
Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography.
Molecular pharmaceutics 17(6), 1884-1898 (2020) doi: 10.1021/acs.molpharmaceut.9b01284

Fukuchi T, Yamamoto S, Kataoka J, et al.
Beta-ray imaging system with γ-ray coincidence for multiple-tracer imaging.
Medical physics 47(2), 587-596 (2020) doi: 10.1002/mp.13947


Photo of Team leder, Yasuyoshi Watanabe

Team LeaderYasuyoshi Watanabe

  • yywata[at]riken.jp
    (Please replace [at] with @)

Deputy Team LeaderYasuhiro Wada

  • yasuwada[at]riken.jp

Deputy Team LeaderShinji Motomura

  • motomura[at]riken.jp

Senior Scientist*Kei Mizuno

  • keimizuno[at]riken.jp

Senior ScientistKayo Takahashi

  • kayo.takahashi[at]riken.jp

Research ScientistYousuke Kanayama

  • ykana[at]riken.jp

Research ScientistAkihiro Sasaki

  • akihiro.sasaki[at]riken.jp

Research ScientistTomonori Fukuchi

  • tfukuchi[at]riken.jp

Research Scientist*Kyosuke Watanabe

Research Scientist*Emi Yamano

Technical ScientistKayo Onoe

Technical ScientistMiki Goto

Expert TechnicianEmi Hayashinaka

Technical Staff IYuka Nakatani

  • yu-nakatani[at]riken.jp

Technical Staff IShino Owada

Technical Staff IYoshino Matsumoto

Technical Staff IAkina Higashi

Research Part-time Worker IIShuhei Yamaguchi

Administrative Part-time Worker IIYoshimi Takemoto

Administrative Part-time Worker IIMaya Mitsuno

Temporary StaffingNatsumi Otsuka

Visiting ResearcherEriko Kawai

AssistantMai Shibata

Assistant *Yoko Nagatomo

Assistant *Miki Fujiwara

(* Concurrent; Please replace [at] with @)