
Team Leader
Yasuyoshi Watanabe
M.D., Ph.D.
Laboratory for Pathophysiological and Health Science
[Closed Mar. 2023]
E-mailyywata[at]riken.jp
Please replace [at] with @.
We provide core technologies to realize health sciences including very early diagnosis, pathophysiology, and preemptive medicine using imaging biomarkers closely related to disease state and pre-disease state (ahead sick), to innovate medical science with promotion of collaborations among all center members.
Research Theme
- Molecular imaging study on newly developed biomarkers for evaluation of health and pre-disease state
- Molecular imaging study on newly developed biomarkers for evaluation of disease state
- Development of molecular imaging indices for products to avoid deterioration of health
Selected Publications
Fukuchi T, Niwa T, Hosoya T, Watanabe Y.
Computational Study for Amino Acid Production from Carboxylic Acid via 14C β-decay.
Journal of the Physical Society of Japan
91, 064301 (2022)
doi: 10.7566/JPSJ.91.064301
Zhang K, Sun Y, Wu S, et al.
Systematic imaging in medicine: a comprehensive review.
European journal of nuclear medicine and molecular imaging
48(6), 1736-1758 (2021)
doi: 10.1007/s00259-020-05107-z
Watanabe Y, Mawatari A, Aita K, et al.
PET imaging of 11C-labeled thiamine tetrahydrofurfuryl disulfide, vitamin B1 derivative: First-in-human study.
Biochemical and biophysical research communications
555, 7-12 (2021)
doi: 10.1016/j.bbrc.2021.03.119
Li D, Hu D, Shigeta M, et al.
Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.
Neuroscience research
165, 45-50 (2021)
doi: 10.1016/j.neures.2020.04.005
Vong K, Tahara T, Urano S, et al.
Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy.
Science advances
7(17), eabg4038 (2021)
doi: 10.1126/sciadv.abg4038
Yamano E, Watanabe Y, Kataoka Y.
Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
International journal of molecular sciences
22(7), 3423 (2021)
doi: 10.3390/ijms22073423
Hu D, Li D, Shigeta M, et al.
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
Biochemical and biophysical research communications
535, 1-5 (2021)
doi: 10.1016/j.bbrc.2020.12.035
Watanabe Y.
PET/SPECT/MRI/fMRI Studies in the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
In: PET and SPECT in Psychiatry (Dierckx RAJO, Otte A, de Vries EFJ, wan Waarde A, Sommer IE, eds.)
Springer, 985-1002 (2021)
Mukai H, Watanabe Y.
Review: PET imaging with macro- and middle-sized molecular probes.
Nuclear medicine and biology
92, 156-170 (2021)
doi: 10.1016/j.nucmedbio.2020.06.007
Mizuno K, Ojiro D, Tanaka T, et al.
Relationship between truck driver fatigue and rear-end collision risk.
PloS one
15(9), e0238738 (2020)
doi: 10.1371/journal.pone.0238738
Nomura S, Takahashi M, Kato AH, et al.
Biosorption-based 64Cu-labeling of bacteria for pharmacokinetic positron-emission tomography.
International journal of pharmaceutics
590, 119950 (2020)
doi: 10.1016/j.ijpharm.2020.119950
Kitami T, Fukuda S, Kato T, et al.
Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.
Scientific reports
10(1), 19933 (2020)
doi: 10.1038/s41598-020-77105-y
Jonasson M, Nordeman P, Eriksson J, et al.
Quantification of aromatase binding in the female human brain using [11 C]cetrozole positron emission tomography.
Journal of neuroscience research
98(11), 2208-2218 (2020)
doi: 10.1002/jnr.24707
Smirnov I, Sibgatullina R, Urano S, et al.
A Strategy for Tumor Targeting by Higher-Order Glycan Pattern Recognition: Synthesis and In Vitro and In Vivo Properties of Glycoalbumins Conjugated with Four Different N-Glycan Molecules.
Small (Weinheim an der Bergstrasse, Germany)
16(46), e2004831 (2020)
doi: 10.1002/smll.202004831
Kawano T, Naito J, Nishioka M, et al.
Effect of Food Containing Paramylon Derived from Euglena gracilis EOD-1 on Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.
Nutrients
12(10), E3098 (2020)
doi: 10.3390/nu12103098
Mizuno K, Sasaki AT, Watanabe K, Watanabe Y.
Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
Nutrients
12(6), E1640 (2020)
doi: 10.3390/nu12061640
Nakaoka T, Uetake Y, Kaneko KI, et al.
Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography.
Molecular pharmaceutics
17(6), 1884-1898 (2020)
doi: 10.1021/acs.molpharmaceut.9b01284
Fukuchi T, Yamamoto S, Kataoka J, et al.
Beta-ray imaging system with γ-ray coincidence for multiple-tracer imaging.
Medical physics
47(2), 587-596 (2020)
doi: 10.1002/mp.13947
Members

Team LeaderYasuyoshi Watanabe
- yywata[at]riken.jp
(Please replace [at] with @)
Deputy Team LeaderYasuhiro Wada
- yasuwada[at]riken.jp
Deputy Team LeaderShinji Motomura
- motomura[at]riken.jp
Senior Scientist*Kei Mizuno
- keimizuno[at]riken.jp
Senior ScientistKayo Takahashi
- kayo.takahashi[at]riken.jp
Research ScientistYousuke Kanayama
- ykana[at]riken.jp
Research ScientistAkihiro Sasaki
- akihiro.sasaki[at]riken.jp
Research ScientistTomonori Fukuchi
- tfukuchi[at]riken.jp
Research Scientist*Kyosuke Watanabe
Research Scientist*Emi Yamano
Technical ScientistKayo Onoe
Technical ScientistMiki Goto
Expert TechnicianEmi Hayashinaka
Technical Staff IYuka Nakatani
- yu-nakatani[at]riken.jp
Technical Staff IShino Owada
Technical Staff IYoshino Matsumoto
Technical Staff IAkina Higashi
Research Part-time Worker IIShuhei Yamaguchi
Administrative Part-time Worker IIYoshimi Takemoto
Administrative Part-time Worker IIMaya Mitsuno
Temporary StaffingNatsumi Otsuka
Visiting ResearcherEriko Kawai
AssistantMai Shibata
Assistant *Yoko Nagatomo
Assistant *Miki Fujiwara
(* Concurrent; Please replace [at] with @)