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研究

研究

BDRでは、様々な分野の研究者が協力して、より高い目標に向かって研究を進めています。

セミナー・シンポジウム

セミナー・イベント

BDRでは、ライフサイエンス分野の国際的な研究者を招いて、年1回のシンポジウムや定期的なセミナーを開催しています。

働く・学ぶ

働く・学ぶ

BDRでは、様々なバックグラウンドを持つ人々を受け入れ、オープンで協力的な研究環境の構築に努めています。

つながる・楽しむ

つながる・楽しむ

BDRでは、様々なメディアや活動を通じて、研究の魅力や意義を社会に発信しています。

ニュース

ニュース

最新の研究、イベント、研究者のインタビューなど、理研BDRの最新情報をお届けします。

BDRについて

BDRについて

理研の強みを生かし学際的なアプローチで生命の根源を探求し、社会の課題に応えます。

業績一覧 | 血管形成研究チーム

業績一覧

Huveneers S, Phng LK.
Endothelial cell mechanics and dynamics in angiogenesis.
Current Opinion in Cell Biology 91, 102441 (2024) doi: 10.1016/j.ceb.2024.102441

Phng LK, Hogan BM.
Endothelial cell transitions in zebrafish vascular development.
Development, Growth & Differentiation 66(6), 357-368 (2024) doi: 10.1111/dgd.12938

Maung Ye SS, Phng LK.
A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration.
PLOS Computational Biology 19(12), e1011665 (2023) doi: 10.1371/journal.pcbi.1011665

Maung Ye SS, Kim JK, Carretero NT, Phng LK.
High-Throughput Imaging of Blood Flow Reveals Developmental Changes in Distribution Patterns of Hemodynamic Quantities in Developing Zebrafish.
Frontiers in Physiology 13, 881929 (2022) doi: 10.3389/fphys.2022.881929

Phng LK, Belting HG.
Endothelial cell mechanics and blood flow forces in vascular morphogenesis.
Seminars in Cell & Developmental Biology 120, 32-43 (2021) doi: 10.1016/j.semcdb.2021.06.005

Kondrychyn I, Kelly DJ, Taberner Carretero N, et al.
Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size.
Nature Communications 11, 5476 (2020) doi: 10.1038/s41467-020-19308-5

Phng LK.
Endothelial cell dynamics during blood vessel morphogenesis.
In: Hirata, H., Iida, A. (eds) Zebrafish, Medaka and Other Small Fishes, Springer, Singapore (2018) doi: 10.1007/978-981-13-1879-5_2

Mathivet T, Bouleti C, Van Woensel M, et al.
Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
EMBO Molecular Medicine 9, 1629-1645 (2017) doi: 10.15252/emmm.201607445

Gebala V, Collins R, Geudens I, et al.
Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Nature Cell Biology 18(4), 443-451 (2016) doi: 10.1038/ncb3320

Phng LK, Gebala V, Bentley K, et al.
Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization.
Developmental Cell 32, 123-132 (2015) doi: 10.1016/j.devcel.2014.11.017

Franco CA, Jones ML, Bernabeu MO, et al.
Dynamic endothelial cell rearrangements drive developmental vessel regression.
PLoS Biology 13(4), e1002125 (2015) doi: 10.1371/journal.pbio.1002125

Wacker A, Gerhardt H, Phng LK.
Tissue guidance without filopodia.
Communicative & Integrative Biology 7, e28820 (2014) doi: 10.4161/cib.28820

Phng LK, Stanchi F, Gerhardt H.
Filopodia are dispensable for endothelial tip cell guidance.
Development 140, 4031-4040 (2013) doi: 10.1242/dev.097352

De Bock K, Georgiadou M, Schoors S, et al.
Role of PFKFB3-driven glycolysis in vessel sprouting.
Cell 154(3), 651-663 (2013) doi: 10.1016/j.cell.2013.06.037

Guarani V, Deflorian G, Franco CA, et al.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Nature 473(7346), 234-238 (2011) doi: 10.1038/nature09917

Phng LK, Potente M, Leslie J D, et al.
Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.
Developmental Cell 16, 70-82 (2009) doi: 10.1016/j.devcel.2008.12.009

Phng LK, Gerhardt H.
Angiogenesis: a team effort coordinated by notch.
Developmental Cell 16(2), 196-208 (2009) doi: 10.1016/j.devcel.2009.01.015

Graupera M, Guillermet-Guibert J, Foukas LC, et al.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
Nature 453(7195), 662-666 (2008) doi: 10.1038/nature06892

Hellström M, Phng LK, Gerhardt H.
VEGF and Notch signaling: the yin and yang of angiogenic sprouting.
Cell Adhesion & Migration 1(3), 133-136 (2007) doi: 10.4161/cam.1.3.4978

Hellström M, Phng LK, Hofmann J H, et al.
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Nature 445, 776-770 (2007) doi: 10.1038/nature05571

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