Publications
Huveneers S, Phng LK.
Endothelial cell mechanics and dynamics in angiogenesis.
Current Opinion in Cell Biology
91, 102441 (2024)
doi: 10.1016/j.ceb.2024.102441
Phng LK, Hogan BM.
Endothelial cell transitions in zebrafish vascular development.
Development, Growth & Differentiation
66(6), 357-368 (2024)
doi: 10.1111/dgd.12938
Maung Ye SS, Phng LK.
A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration.
PLOS Computational Biology
19(12), e1011665 (2023)
doi: 10.1371/journal.pcbi.1011665
Maung Ye SS, Kim JK, Carretero NT, Phng LK.
High-Throughput Imaging of Blood Flow Reveals Developmental Changes in Distribution Patterns of Hemodynamic Quantities in Developing Zebrafish.
Frontiers in Physiology
13, 881929 (2022)
doi: 10.3389/fphys.2022.881929
Phng LK, Belting HG.
Endothelial cell mechanics and blood flow forces in vascular morphogenesis.
Seminars in Cell & Developmental Biology
120, 32-43 (2021)
doi: 10.1016/j.semcdb.2021.06.005
Kondrychyn I, Kelly DJ, Taberner Carretero N, et al.
Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size.
Nature Communications
11, 5476 (2020)
doi: 10.1038/s41467-020-19308-5
Phng LK.
Endothelial cell dynamics during blood vessel morphogenesis.
In: Hirata, H., Iida, A. (eds)
Zebrafish, Medaka and Other Small Fishes, Springer, Singapore (2018)
doi: 10.1007/978-981-13-1879-5_2
Mathivet T, Bouleti C, Van Woensel M, et al.
Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
EMBO Molecular Medicine
9, 1629-1645 (2017)
doi: 10.15252/emmm.201607445
Gebala V, Collins R, Geudens I, et al.
Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Nature Cell Biology
18(4), 443-451 (2016)
doi: 10.1038/ncb3320
Phng LK, Gebala V, Bentley K, et al.
Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization.
Developmental Cell
32, 123-132 (2015)
doi: 10.1016/j.devcel.2014.11.017
Franco CA, Jones ML, Bernabeu MO, et al.
Dynamic endothelial cell rearrangements drive developmental vessel regression.
PLoS Biology
13(4), e1002125 (2015)
doi: 10.1371/journal.pbio.1002125
Wacker A, Gerhardt H, Phng LK.
Tissue guidance without filopodia.
Communicative & Integrative Biology
7, e28820 (2014)
doi: 10.4161/cib.28820
Phng LK, Stanchi F, Gerhardt H.
Filopodia are dispensable for endothelial tip cell guidance.
Development
140, 4031-4040 (2013)
doi: 10.1242/dev.097352
De Bock K, Georgiadou M, Schoors S, et al.
Role of PFKFB3-driven glycolysis in vessel sprouting.
Cell
154(3), 651-663 (2013)
doi: 10.1016/j.cell.2013.06.037
Guarani V, Deflorian G, Franco CA, et al.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Nature
473(7346), 234-238 (2011)
doi: 10.1038/nature09917
Phng LK, Potente M, Leslie J D, et al.
Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.
Developmental Cell
16, 70-82 (2009)
doi: 10.1016/j.devcel.2008.12.009
Phng LK, Gerhardt H.
Angiogenesis: a team effort coordinated by notch.
Developmental Cell
16(2), 196-208 (2009)
doi: 10.1016/j.devcel.2009.01.015
Graupera M, Guillermet-Guibert J, Foukas LC, et al.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
Nature
453(7195), 662-666 (2008)
doi: 10.1038/nature06892
Hellström M, Phng LK, Gerhardt H.
VEGF and Notch signaling: the yin and yang of angiogenic sprouting.
Cell Adhesion & Migration
1(3), 133-136 (2007)
doi: 10.4161/cam.1.3.4978
Hellström M, Phng LK, Hofmann J H, et al.
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Nature
445, 776-770 (2007)
doi: 10.1038/nature05571