ロゴマーク
研究

研究

BDRでは、様々な分野の研究者が協力して、より高い目標に向かって研究を進めています。

セミナー・シンポジウム

セミナー・イベント

BDRでは、ライフサイエンス分野の国際的な研究者を招いて、年1回のシンポジウムや定期的なセミナーを開催しています。

働く・学ぶ

働く・学ぶ

BDRでは、様々なバックグラウンドを持つ人々を受け入れ、オープンで協力的な研究環境の構築に努めています。

つながる・楽しむ

つながる・楽しむ

BDRでは、様々なメディアや活動を通じて、研究の魅力や意義を社会に発信しています。

ニュース

ニュース

最新の研究、イベント、研究者のインタビューなど、理研BDRの最新情報をお届けします。

BDRについて

BDRについて

理研の強みを生かし学際的なアプローチで生命の根源を探求し、社会の課題に応えます。

業績一覧 | 栄養応答研究チーム

業績一覧

Kosakamoto H, Miura M, Obata F.
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila.
Development 151(1), dev202372 Mon Jan 01 00:00:00 JST 2024 doi: 10.1242/dev.202372

Kosakamoto H, Obata F, Kuraishi J, et al.
Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila.
Nature Communications 14(1), 7832 Tue Dec 05 00:00:00 JST 2023 doi: 10.1038/s41467-023-43550-2

Sakuma C, Obata F.
Fat gain or eat cysteine.
Cell Research Mon Apr 24 00:00:00 JST 2023 doi: 10.1038/s41422-023-00813-3

Sakuma C, Maekawa E, Kanuka H.
Automated Long-Term Monitoring of the Heat-Seeking Behavior of Mosquitoes.
Cold Spring Harbor Protocols Thu Apr 06 00:00:00 JST 2023 doi: 10.1101/pdb.prot108173

Sakuma C, Maekawa E, Kanuka H.
Key Features and Considerations for Using Automated Long-Term Monitoring of Heat-Seeking Behavior of Mosquitoes.
Cold Spring Harbor Protocols Thu Apr 06 00:00:00 JST 2023 doi: 10.1101/pdb.top107665

Onuma T, Yamauchi T, Kosakamoto H, et al.
Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.
PLOS Genetics 19(4), e1010709 Sat Apr 01 00:00:00 JST 2023 doi: 10.1371/journal.pgen.1010709

Kosakamoto H, Okamoto N, Aikawa H, et al.
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.
Nature Metabolism 4(7), 944-959 Fri Jul 01 00:00:00 JST 2022 doi: 10.1038/s42255-022-00608-7

Spratt SJ, Oguchi K, Miura K, et al.
Probing Methionine Uptake in Live Cells by Deuterium Labeling and Stimulated Raman Scattering.
Journal of Physical Chemistry. B 126(8), 1633-1639 Thu Mar 03 00:00:00 JST 2022 doi: 10.1021/acs.jpcb.1c08343

Yamashita K, Oi A, Kosakamoto H, et al.
Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan.
Disease Models & Mechanisms 14(9), dmm049103 Wed Sep 01 00:00:00 JST 2021 doi: 10.1242/dmm.049103

Yoshinari Y, Kosakamoto H, Kamiyama T, et al.
The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.
Nature Communications 12(1), 4818 Tue Aug 10 00:00:00 JST 2021 doi: 10.1038/s41467-021-25146-w

Kashima H, Kamiya M, Obata F, et al.
Photoactivatable fluorophores for durable labelling of individual cells.
Chemical Communications 57(47), 5802-5805 Thu Jun 10 00:00:00 JST 2021 doi: 10.1039/d1cc01488a

Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience 23, 101477 Wed Sep 02 00:00:00 JST 2020 doi: 10.1016/j.isci.2020.101477

Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports 32(3), 107938 Tue Jul 21 00:00:00 JST 2020 doi: 10.1016/j.celrep.2020.107938

Kosakamoto H, Fujisawa Y, Obata F, Miura M.
High expression of A-type lamin in the leading front is required for Drosophila thorax closure.
Biochemical and Biophysical Research Communications 499(2), 209-214 Sat May 05 00:00:00 JST 2018 doi: 10.1016/j.bbrc.2018.03.128

Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell 44(6), 741-751 Mon Mar 26 00:00:00 JST 2018 doi: 10.1016/j.devcel.2018.02.017

Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications 9(1), 975 Wed Mar 07 00:00:00 JST 2018 doi: 10.1038/s41467-018-03070-w

Stefana MI, Driscoll PC, Obata F, et al.
Developmental diet regulates Drosophila lifespan via lipid autotoxins.
Nature Communications 8(1), 1384 Thu Nov 09 00:00:00 JST 2017 doi: 10.1038/s41467-017-01740-9

Kashio S, Obata F, Miura M.
How tissue damage MET metabolism: Regulation of the systemic damage response.
Fly 11(1), 27-36 Mon Jan 02 00:00:00 JST 2017 doi: 10.1080/19336934.2016.1221549

Obata F.
Tissue nonautonomous effects of fat body methionine metabolism on epithelial repair in Drosophila melanogaster.
2016 International Congress of Entomology Sun Sep 18 00:00:00 JST 2016 doi: 10.1603/ice.2016.111433

Shinoda N, Obata F, Zhang L, Miura M.
Drosophila SETDB1 and caspase cooperatively fine-tune cell fate determination of sensory organ precursor.
Genes to Cells 21(4), 378-386 Fri Apr 01 00:00:00 JST 2016 doi: 10.1111/gtc.12348

Obata F, Miura M.
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
Nature Communications 6, 8332 Fri Sep 18 00:00:00 JST 2015 doi: 10.1038/ncomms9332

Obata F, Tanaka S, Kashio S, et al.
Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.
BMC Biology 13, 48 Wed Jul 08 00:00:00 JST 2015 doi: 10.1186/s12915-015-0160-2

Obata F, Tomioka K, Miura M.
Transcriptional profiling of apoptosis-deficient Drosophila mutants.
Genomics Data 2, 254-257 Mon Dec 01 00:00:00 JST 2014 doi: 10.1016/j.gdata.2014.08.001

Ichikawa Y, Kamiya M, Obata F, et al.
Selective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.
Angewandte Chemie 53(26), 6772-6775 Mon Jun 23 00:00:00 JST 2014 doi: 10.1002/anie.201403221

Kashio S, Obata F, Miura M.
Interplay of cell proliferation and cell death in Drosophila tissue regeneration.
Development, Growth & Differentiation 56(5), 368-375 Sun Jun 01 00:00:00 JST 2014 doi: 10.1111/dgd.12139

Obata F, Kuranaga E, Tomioka K, et al.
Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
Cell Reports 7(3), 821-833 Thu May 08 00:00:00 JST 2014 doi: 10.1016/j.celrep.2014.03.046

Shiraki N, Shiraki Y, Tsuyama T, et al.
Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.
Cell Metabolism 19(5), 780-794 Tue May 06 00:00:00 JST 2014 doi: 10.1016/j.cmet.2014.03.017

Ming M, Obata F, Kuranaga E, Miura M.
Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.
Journal of Biological Chemistry 289(11), 7558-7568 Fri Mar 14 00:00:00 JST 2014 doi: 10.1074/jbc.M113.543884

Obata F, Kitami M, Inoue Y, et al.
Analysis of the region for receptor binding and triggering of oligomerization on Bacillus thuringiensis Cry1Aa toxin.
FEBS Journal 276(20), 5949-5959 Thu Oct 01 00:00:00 JST 2009 doi: 10.1111/j.1742-4658.2009.07275.x

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