ロゴマーク
研究

研究

BDRでは、様々な分野の研究者が協力して、より高い目標に向かって研究を進めています。

セミナー・シンポジウム

セミナー・イベント

BDRでは、ライフサイエンス分野の国際的な研究者を招いて、年1回のシンポジウムや定期的なセミナーを開催しています。

キャリア・育成

キャリア・育成

BDRでは、様々なバックグラウンドを持つ人々を受け入れ、オープンで協力的な研究環境の構築に努めています。

つながる・楽しむ

つながる・楽しむ

BDRでは、様々なメディアや活動を通じて、研究の魅力や意義を社会に発信しています。

ニュース

ニュース

最新の研究、イベント、研究者のインタビューなど、理研BDRの最新情報をお届けします。

BDRについて

BDRについて

理研の強みを生かし学際的なアプローチで生命の根源を探求し、社会の課題に応えます。

業績一覧 | 栄養応答研究チーム

業績一覧

Kosakamoto H, Okamoto N, Aikawa H, et al.
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.
Nature Metabolism 4(7), 944-959 (2022) doi: 10.1038/s42255-022-00608-7

Spratt SJ, Oguchi K, Miura K, et al.
Probing Methionine Uptake in Live Cells by Deuterium Labeling and Stimulated Raman Scattering.
Journal of Physical Chemistry. B 126(8), 1633-1639 (2022) doi: 10.1021/acs.jpcb.1c08343

Yamashita K, Oi A, Kosakamoto H, et al.
Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan.
Disease Models & Mechanisms 14(9), dmm049103 (2021) doi: 10.1242/dmm.049103

Yoshinari Y, Kosakamoto H, Kamiyama T, et al.
The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.
Nature Communications 12(1), 4818 (2021) doi: 10.1038/s41467-021-25146-w

Kashima H, Kamiya M, Obata F, et al.
Photoactivatable fluorophores for durable labelling of individual cells.
Chemical Communications 57(47), 5802-5805 (2021) doi: 10.1039/d1cc01488a

Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience 23, 101477 (2020) doi: 10.1016/j.isci.2020.101477

Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports 32(3), 107938 (2020) doi: 10.1016/j.celrep.2020.107938

Kosakamoto H, Fujisawa Y, Obata F, Miura M.
High expression of A-type lamin in the leading front is required for Drosophila thorax closure.
Biochemical and Biophysical Research Communications 499(2), 209-214 (2018) doi: 10.1016/j.bbrc.2018.03.128

Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell 44(6), 741-751 (2018) doi: 10.1016/j.devcel.2018.02.017

Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications 9(1), 975 (2018) doi: 10.1038/s41467-018-03070-w

Stefana MI, Driscoll PC, Obata F, et al.
Developmental diet regulates Drosophila lifespan via lipid autotoxins.
Nature Communications 8(1), 1384 (2017) doi: 10.1038/s41467-017-01740-9

Kashio S, Obata F, Miura M.
How tissue damage MET metabolism: Regulation of the systemic damage response.
Fly 11(1), 27-36 (2017) doi: 10.1080/19336934.2016.1221549

Obata F.
Tissue nonautonomous effects of fat body methionine metabolism on epithelial repair in Drosophila melanogaster.
2016 International Congress of Entomology (2016) doi: 10.1603/ice.2016.111433

Shinoda N, Obata F, Zhang L, Miura M.
Drosophila SETDB1 and caspase cooperatively fine-tune cell fate determination of sensory organ precursor.
Genes to Cells 21(4), 378-386 (2016) doi: 10.1111/gtc.12348

Obata F, Miura M.
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
Nature Communications 6, 8332 (2015) doi: 10.1038/ncomms9332

Obata F, Tanaka S, Kashio S, et al.
Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.
BMC Biology 13, 48 (2015) doi: 10.1186/s12915-015-0160-2

Obata F, Tomioka K, Miura M.
Transcriptional profiling of apoptosis-deficient Drosophila mutants.
Genomics Data 2, 254-257 (2014) doi: 10.1016/j.gdata.2014.08.001

Ichikawa Y, Kamiya M, Obata F, et al.
Selective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.
Angewandte Chemie 53(26), 6772-6775 (2014) doi: 10.1002/anie.201403221

Kashio S, Obata F, Miura M.
Interplay of cell proliferation and cell death in Drosophila tissue regeneration.
Development, Growth & Differentiation 56(5), 368-375 (2014) doi: 10.1111/dgd.12139

Obata F, Kuranaga E, Tomioka K, et al.
Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
Cell Reports 7(3), 821-833 (2014) doi: 10.1016/j.celrep.2014.03.046

Shiraki N, Shiraki Y, Tsuyama T, et al.
Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.
Cell Metabolism 19(5), 780-794 (2014) doi: 10.1016/j.cmet.2014.03.017

Ming M, Obata F, Kuranaga E, Miura M.
Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.
Journal of Biological Chemistry 289(11), 7558-7568 (2014) doi: 10.1074/jbc.M113.543884

Obata F, Kitami M, Inoue Y, et al.
Analysis of the region for receptor binding and triggering of oligomerization on Bacillus thuringiensis Cry1Aa toxin.
FEBS Journal 276(20), 5949-5959 (2009) doi: 10.1111/j.1742-4658.2009.07275.x

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