Publications | Laboratory for Nutritional Biology
Publications
Kosakamoto H, Miura M, Obata F.
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila.
Development
151(1), dev202372 Mon Jan 01 00:00:00 JST 2024
doi: 10.1242/dev.202372
Kosakamoto H, Obata F, Kuraishi J, et al.
Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila.
Nature Communications
14(1), 7832 Tue Dec 05 00:00:00 JST 2023
doi: 10.1038/s41467-023-43550-2
Sakuma C, Obata F.
Fat gain or eat cysteine.
Cell Research
Mon Apr 24 00:00:00 JST 2023
doi: 10.1038/s41422-023-00813-3
Sakuma C, Maekawa E, Kanuka H.
Automated Long-Term Monitoring of the Heat-Seeking Behavior of Mosquitoes.
Cold Spring Harbor Protocols
Thu Apr 06 00:00:00 JST 2023
doi: 10.1101/pdb.prot108173
Sakuma C, Maekawa E, Kanuka H.
Key Features and Considerations for Using Automated Long-Term Monitoring of Heat-Seeking Behavior of Mosquitoes.
Cold Spring Harbor Protocols
Thu Apr 06 00:00:00 JST 2023
doi: 10.1101/pdb.top107665
Onuma T, Yamauchi T, Kosakamoto H, et al.
Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.
PLOS Genetics
19(4), e1010709 Sat Apr 01 00:00:00 JST 2023
doi: 10.1371/journal.pgen.1010709
Kosakamoto H, Okamoto N, Aikawa H, et al.
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.
Nature Metabolism
4(7), 944-959 Fri Jul 01 00:00:00 JST 2022
doi: 10.1038/s42255-022-00608-7
Spratt SJ, Oguchi K, Miura K, et al.
Probing Methionine Uptake in Live Cells by Deuterium Labeling and Stimulated Raman Scattering.
Journal of Physical Chemistry. B
126(8), 1633-1639 Thu Mar 03 00:00:00 JST 2022
doi: 10.1021/acs.jpcb.1c08343
Yamashita K, Oi A, Kosakamoto H, et al.
Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan.
Disease Models & Mechanisms
14(9), dmm049103 Wed Sep 01 00:00:00 JST 2021
doi: 10.1242/dmm.049103
Yoshinari Y, Kosakamoto H, Kamiyama T, et al.
The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.
Nature Communications
12(1), 4818 Tue Aug 10 00:00:00 JST 2021
doi: 10.1038/s41467-021-25146-w
Kashima H, Kamiya M, Obata F, et al.
Photoactivatable fluorophores for durable labelling of individual cells.
Chemical Communications
57(47), 5802-5805 Thu Jun 10 00:00:00 JST 2021
doi: 10.1039/d1cc01488a
Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience
23, 101477 Wed Sep 02 00:00:00 JST 2020
doi: 10.1016/j.isci.2020.101477
Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports
32(3), 107938 Tue Jul 21 00:00:00 JST 2020
doi: 10.1016/j.celrep.2020.107938
Kosakamoto H, Fujisawa Y, Obata F, Miura M.
High expression of A-type lamin in the leading front is required for Drosophila thorax closure.
Biochemical and Biophysical Research Communications
499(2), 209-214 Sat May 05 00:00:00 JST 2018
doi: 10.1016/j.bbrc.2018.03.128
Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell
44(6), 741-751 Mon Mar 26 00:00:00 JST 2018
doi: 10.1016/j.devcel.2018.02.017
Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications
9(1), 975 Wed Mar 07 00:00:00 JST 2018
doi: 10.1038/s41467-018-03070-w
Stefana MI, Driscoll PC, Obata F, et al.
Developmental diet regulates Drosophila lifespan via lipid autotoxins.
Nature Communications
8(1), 1384 Thu Nov 09 00:00:00 JST 2017
doi: 10.1038/s41467-017-01740-9
Kashio S, Obata F, Miura M.
How tissue damage MET metabolism: Regulation of the systemic damage response.
Fly
11(1), 27-36 Mon Jan 02 00:00:00 JST 2017
doi: 10.1080/19336934.2016.1221549
Obata F.
Tissue nonautonomous effects of fat body methionine metabolism on epithelial repair in Drosophila melanogaster.
2016 International Congress of Entomology
Sun Sep 18 00:00:00 JST 2016
doi: 10.1603/ice.2016.111433
Shinoda N, Obata F, Zhang L, Miura M.
Drosophila SETDB1 and caspase cooperatively fine-tune cell fate determination of sensory organ precursor.
Genes to Cells
21(4), 378-386 Fri Apr 01 00:00:00 JST 2016
doi: 10.1111/gtc.12348
Obata F, Miura M.
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
Nature Communications
6, 8332 Fri Sep 18 00:00:00 JST 2015
doi: 10.1038/ncomms9332
Obata F, Tanaka S, Kashio S, et al.
Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.
BMC Biology
13, 48 Wed Jul 08 00:00:00 JST 2015
doi: 10.1186/s12915-015-0160-2
Obata F, Tomioka K, Miura M.
Transcriptional profiling of apoptosis-deficient Drosophila mutants.
Genomics Data
2, 254-257 Mon Dec 01 00:00:00 JST 2014
doi: 10.1016/j.gdata.2014.08.001
Ichikawa Y, Kamiya M, Obata F, et al.
Selective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.
Angewandte Chemie
53(26), 6772-6775 Mon Jun 23 00:00:00 JST 2014
doi: 10.1002/anie.201403221
Kashio S, Obata F, Miura M.
Interplay of cell proliferation and cell death in Drosophila tissue regeneration.
Development, Growth & Differentiation
56(5), 368-375 Sun Jun 01 00:00:00 JST 2014
doi: 10.1111/dgd.12139
Obata F, Kuranaga E, Tomioka K, et al.
Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
Cell Reports
7(3), 821-833 Thu May 08 00:00:00 JST 2014
doi: 10.1016/j.celrep.2014.03.046
Shiraki N, Shiraki Y, Tsuyama T, et al.
Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.
Cell Metabolism
19(5), 780-794 Tue May 06 00:00:00 JST 2014
doi: 10.1016/j.cmet.2014.03.017
Ming M, Obata F, Kuranaga E, Miura M.
Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.
Journal of Biological Chemistry
289(11), 7558-7568 Fri Mar 14 00:00:00 JST 2014
doi: 10.1074/jbc.M113.543884
Obata F, Kitami M, Inoue Y, et al.
Analysis of the region for receptor binding and triggering of oligomerization on Bacillus thuringiensis Cry1Aa toxin.
FEBS Journal
276(20), 5949-5959 Thu Oct 01 00:00:00 JST 2009
doi: 10.1111/j.1742-4658.2009.07275.x
* denotes equal contribution.