発生現象は、分子、細胞、組織という異なる空間スケールでの現象からなるマルチスケールなシステムであると同時に、分子による時空間情報の伝達や読み取り、細胞の増殖や運動を通じた組織内応力の発生、それに伴う幾何学的な組織変形といったマルチフィジクスなシステムでもあります。本研究チームでは、理論と実験の両研究を通じ、異なるスケールや性質をもつ現象、及び現象間の動的かつ協調的な相互作用を定量的に理解することを目指します。
研究テーマ
- 器官レベルの形態形成定量イメージングと幾何学的解析
- 微成長組織内における細胞の時空間認識メカニズム
- 器官形態形成過程の力学モデリング
- 細胞集団運動を通じた空間パターニングの計測とモデリング
主要論文
Ohtsuka D, Kida N, Lee SW, et al.
Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia.
Science Advances
8(28), eabn2330 Fri Jul 15 00:00:00 JST 2022
doi: 10.1126/sciadv.abn2330
Kawahira N, Ohtsuka D, Kida N, et al.
Quantitative analysis of 3D tissue deformation reveals key cellular mechanism associated with initial heart looping.
Cell Reports
30, 3889-3903 Tue Dec 01 00:00:00 JST 2020
doi: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30239-4
Yamada T, Hironaka KI, Habara O, et al.
A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila.
Nature metabolism
2(10), 1096-1112 Thu Oct 01 00:00:00 JST 2020
doi: 10.1038/s42255-020-00293-4
Suzuki T, Morishita Y.
A quantitative approach to understanding vertebrate limb morphogenesis at the macroscopic tissue level.
Current Opinion in Genetics and Development
45, 108-114 Fri Dec 01 00:00:00 JST 2017
doi: 10.1016/j.gde.2017.04.005
Lee SW, Morishita Y.
Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.
Plos Computational Biology
13(7), e1005651 Wed Nov 01 00:00:00 JST 2017
doi: 10.1371/journal.pcbi.1005651
Morishita Y, Hironaka K, Lee SW, et al.
Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells.
Nature Communications
8, 15 Sun Oct 01 00:00:00 JST 2017
doi: 10.1038/s41467-017-00023-7
Hironaka K, Morishita Y.
Adaptive significance of critical weight for metamorphosis in holometabolous insects.
Journal of Theoretical Biology
417, 68-83 Fri Sep 01 00:00:00 JST 2017
doi: 10.1016/j.jtbi.2017.01.014
Morishita Y, Kuroiwa A, Suzuki T.
Quantitative analysis of tissue deformation dynamics reveals three characteristic growth modes and globally aligned anisotropic tissue deformation during chick limb development.
Development
142(9), 1672-1683 Tue Dec 01 00:00:00 JST 2015
doi: 10.1242/dev.109728
Morishita Y, Suzuki T.
Bayesian inference of whole-organ deformation dynamics from limited space-time point data.
Journal of Theoretical Biology
357, 74-85 Mon Dec 01 00:00:00 JST 2014
doi: 10.1016/j.jtbi.2014.04.027
Hironaka K, Morishita Y.
Encoding and decoding of positional information in morphogen-dependent patterning.
Current Opinion in Genetics and Development
22(6), 553-561 Sat Dec 01 00:00:00 JST 2012
doi: 10.1016/j.gde.2012.10.002
Morishita Y, Iwasa Y.
Coding Design of Positional Information for Robust Morphogenesis.
Biophysical Journal
101(10), 2324-2335 Thu Dec 01 00:00:00 JST 2011
doi: 10.1016/j.bpj.2011.09.048
Morishita Y, Iwasa Y.
Accuracy of positional information provided by multiple morphogen gradients with correlated noise.
Physical Review E
79(6), 061905 Tue Dec 01 00:00:00 JST 2009
doi: 10.1103/PhysRevE.79.061905
Morishita Y, Iwasa Y.
Optimal placement of multiple morphogen sources.
Physical Review E
77(4), 041909 Mon Dec 01 00:00:00 JST 2008
doi: 10.1103/PhysRevE.77.041909
