Team Leader
Yoshihiro Morishita
Ph.D.
Laboratory for Developmental Morphogeometry
LocationKobe
E-mailyoshihiro.morishita[at]riken.jp
Please replace [at] with @.
Developmental phenomena comprise a multiscalar system extending across a range of spatial scales, from molecular to cellular to histological. Such phenomena are also multiphysical, in that they involve the transmission and reception of positional information through diffusion and reactions of chemicals, and the generation of forces within tissues and concomitant geometrical deformation through the proliferation and migration of cells. The Laboratory for Developmental Morphogeometry takes theoretical and experimental approaches to the study of developmental phenomena comprising multiple scales and properties, and the quantitative measurement of dynamic and coordinated interactions between such phenomena.
Research Theme
- Quantitative imaging and geometrical analysis of organ morphogenesis
- Space-time recognition of cells in growing tissues
- Mechanical modeling of organ morphogenesis
- Measurement and modeling of spatial patterning processes through collective cell movement
Selected Publications
Kawasumi-Kita A, Lee SW, Ohtsuka D, et al.
hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration.
Nature Communications
15(1), 3340 (2024)
doi: 10.1038/s41467-024-47093-y
Morishita Y, Lee SW, Suzuki T, et al.
An archetype and scaling of developmental tissue dynamics across species.
Nature Communications
14(1), 8199 (2023)
doi: 10.1038/s41467-023-43902-y
Ohtsuka D, Kida N, Lee SW, et al.
Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia.
Science Advances
8(28), eabn2330 (2022)
doi: 10.1126/sciadv.abn2330
Kawahira N, Ohtsuka D, Kida N, et al.
Quantitative analysis of 3D tissue deformation reveals key cellular mechanism associated with initial heart looping.
Cell Reports
30, 3889-3903 (2020)
doi: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30239-4
Lee SW, Morishita Y.
Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.
Plos Computational Biology
13(7), e1005651 (2017)
doi: 10.1371/journal.pcbi.1005651
Morishita Y, Hironaka K, Lee SW, et al.
Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells.
Nature Communications
8, 15 (2017)
doi: 10.1038/s41467-017-00023-7
Morishita Y, Kuroiwa A, Suzuki T.
Quantitative analysis of tissue deformation dynamics reveals three characteristic growth modes and globally aligned anisotropic tissue deformation during chick limb development.
Development
142(9), 1672-1683 (2015)
doi: 10.1242/dev.109728
Morishita Y, Suzuki T.
Bayesian inference of whole-organ deformation dynamics from limited space-time point data.
Journal of Theoretical Biology
357, 74-85 (2014)
doi: 10.1016/j.jtbi.2014.04.027
Hironaka K, Morishita Y.
Encoding and decoding of positional information in morphogen-dependent patterning.
Current Opinion in Genetics and Development
22(6), 553-561 (2012)
doi: 10.1016/j.gde.2012.10.002
Morishita Y, Iwasa Y.
Coding Design of Positional Information for Robust Morphogenesis.
Biophysical Journal
101(10), 2324-2335 (2011)
doi: 10.1016/j.bpj.2011.09.048
