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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Team Leader
Genshiro A. Sunagawa M.D., Ph.D.

Laboratory for Hibernation Biology

LocationKobe / Developmental Biology Buildings

E-maillhb_info[at]ml.riken.jp

Please replace [at] with @.

Recruiting graduate students

Toward synthetic hibernation

Our goal is the clinical application of active hypometabolism. We aim to provide effective and meaningful treatment for issues in modern medicine that stem from a high basal metabolic rate of human or human tissues. We believe synthetic hibernation for human can drastically improve medical transportation, tissue preservation, and the safety of general anesthesia. Moreover, if human lifespan can be safely extended by synthetic hibernation, traveling to the future or to deep space would not be a fiction anymore. The spaciotemporal cognitive function of human will change totally. Toward human hibernation, we will especially focus on discovering the mechanism of natural hibernation and torpor.

Rodents in hibernation-like state

Selected Publications

Suita K, Ishikawa K, Kaneko M, et al.
Mouse embryonic stem cells embody organismal-level cold resistance.
Cell Reports 42(8), 112954 Tue Aug 29 00:00:00 JST 2023 doi: 10.1016/j.celrep.2023.112954

Kyo S, Murata K, Kawatou M, et al.
Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.
JTCVS Open 12, 201-210 Thu Dec 01 00:00:00 JST 2022 doi: 10.1016/j.xjon.2022.11.001

Deviatiiarov R, Ishikawa K, Gazizova G, et al.
Integrative transcription start site analysis and physiological phenotyping reveal torpor-specific expression program in mouse skeletal muscle.
Communications Biology 4(1), 1290 Mon Nov 15 00:00:00 JST 2021 doi: 10.1038/s42003-021-02819-2

Takahashi TM, Sunagawa GA, Soya S, et al.
A discrete neuronal circuit induces a hibernation-like state in rodents.
Nature 583(7814), 109-114 Wed Jul 01 00:00:00 JST 2020 doi: 10.1038/s41586-020-2163-6

Iraha S, Tu HY, Yamasaki S, et al.
Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.
Stem Cell Reports 10(3), 1059-1074 Tue Mar 13 00:00:00 JST 2018 doi: 10.1016/j.stemcr.2018.01.032

Mandai M, Fujii M, Hashiguchi T, et al.
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.
Stem Cell Reports 8(1), 69-83 Tue Jan 10 00:00:00 JST 2017 doi: 10.1016/j.stemcr.2016.12.008

Sunagawa GA, Takahashi M.
Hypometabolism during Daily Torpor in Mice is Dominated by Reduction in the Sensitivity of the Thermoregulatory System.
Scientific Reports 6, 37011 Tue Nov 15 00:00:00 JST 2016 doi: 10.1038/srep37011

Fujii M, Sunagawa GA, Kondo M, et al.
Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.
Scientific Reports 6, 30719 Tue Aug 02 00:00:00 JST 2016 doi: 10.1038/srep30719

Tatsuki F, Sunagawa GA, Shi S, et al.
Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals.
Neuron 90(1), 70-85 Wed Apr 06 00:00:00 JST 2016 doi: 10.1016/j.neuron.2016.02.032

Sunagawa GA, Sumiyama K, Ukai-Tadenuma M, et al.
Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
Cell Reports 14(3), 662-677 Tue Jan 26 00:00:00 JST 2016 doi: 10.1016/j.celrep.2015.12.052

Sunagawa GA, Séi H, Shimba S, et al.
FASTER: an unsupervised fully automated sleep staging method for mice.
Genes to Cells 18(6), 502-518 Sat Jun 01 00:00:00 JST 2013 doi: 10.1111/gtc.12053

Members

Genshiro A. Sunagawa

Team Leader

Hiroaki Ono

Research Scientist

Daisuke Tone

Research Scientist

Kiyomi Ishikawa

Technical Staff II

Ayaka Wataki

Technical Staff II

Shoko Fujino

Technical Staff II

Makiya Matsumoto

Technical Staff II

Risa Kakimoto

Student Trainee

Hiroki Yoshida

Student Trainee

Tomoko Kamatani

Assistant

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