Team Leader
Genshiro A. Sunagawa
M.D., Ph.D.
Laboratory for Hibernation Biology
LocationKobe / Developmental Biology Buildings
E-maillhb_info[at]ml.riken.jp
Please replace [at] with @.
Our goal is the clinical application of active hypometabolism. We aim to provide effective and meaningful treatment for issues in modern medicine that stem from a high basal metabolic rate of human or human tissues. We believe synthetic hibernation for human can drastically improve medical transportation, tissue preservation, and the safety of general anesthesia. Moreover, if human lifespan can be safely extended by synthetic hibernation, traveling to the future or to deep space would not be a fiction anymore. The spaciotemporal cognitive function of human will change totally. Toward human hibernation, we will especially focus on discovering the mechanism of natural hibernation and torpor.
Selected Publications
Suita K, Ishikawa K, Kaneko M, et al.
Mouse embryonic stem cells embody organismal-level cold resistance.
Cell Reports
42(8), 112954 (2023)
doi: 10.1016/j.celrep.2023.112954
Kyo S, Murata K, Kawatou M, et al.
Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.
JTCVS Open
12, 201-210 (2022)
doi: 10.1016/j.xjon.2022.11.001
Deviatiiarov R, Ishikawa K, Gazizova G, et al.
Integrative transcription start site analysis and physiological phenotyping reveal torpor-specific expression program in mouse skeletal muscle.
Communications Biology
4(1), 1290 (2021)
doi: 10.1038/s42003-021-02819-2
Takahashi TM, Sunagawa GA, Soya S, et al.
A discrete neuronal circuit induces a hibernation-like state in rodents.
Nature
583(7814), 109-114 (2020)
doi: 10.1038/s41586-020-2163-6
Iraha S, Tu HY, Yamasaki S, et al.
Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.
Stem Cell Reports
10(3), 1059-1074 (2018)
doi: 10.1016/j.stemcr.2018.01.032
Mandai M, Fujii M, Hashiguchi T, et al.
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice.
Stem Cell Reports
8(1), 69-83 (2017)
doi: 10.1016/j.stemcr.2016.12.008
Sunagawa GA, Takahashi M.
Hypometabolism during Daily Torpor in Mice is Dominated by Reduction in the Sensitivity of the Thermoregulatory System.
Scientific Reports
6, 37011 (2016)
doi: 10.1038/srep37011
Fujii M, Sunagawa GA, Kondo M, et al.
Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.
Scientific Reports
6, 30719 (2016)
doi: 10.1038/srep30719
Tatsuki F, Sunagawa GA, Shi S, et al.
Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals.
Neuron
90(1), 70-85 (2016)
doi: 10.1016/j.neuron.2016.02.032
Sunagawa GA, Sumiyama K, Ukai-Tadenuma M, et al.
Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
Cell Reports
14(3), 662-677 (2016)
doi: 10.1016/j.celrep.2015.12.052
Sunagawa GA, Séi H, Shimba S, et al.
FASTER: an unsupervised fully automated sleep staging method for mice.
Genes to Cells
18(6), 502-518 (2013)
doi: 10.1111/gtc.12053
Members
Genshiro A. Sunagawa
Team Leader
Hiroaki Ono
Research Scientist
Daisuke Tone
Research Scientist
Kiyomi Ishikawa
Technical Staff II
Ayaka Wataki
Technical Staff II
Shoko Fujino
Technical Staff II
Makiya Matsumoto
Technical Staff II
Risa Kakimoto
Student Trainee
Hiroki Yoshida
Student Trainee
Tomoko Kamatani
Assistant
News
Feb. 28, 2024 BDR News
Public Events
Exhibit at SSH events in Hyogo Prefecture
Aug. 18, 2023 Research
Towards organ preservation: Animal resistance to cold reflected in stem cells
Feb. 7, 2023 BDR News
Public Events
Taking part in the Science Fair in Hyogo
Dec. 9, 2022 BDR News
RIKEN BDR welcomes Genshiro A. Sunagawa as team leader of the new Laboratory for Hibernation Biology
Nov. 18, 2022 Research
Inducing hibernation-like state in mice can protect organs during heart surgery
Dec. 25, 2020 Research
Hijacking hibernation
Aug. 28, 2020 Research
A neural circuit that makes rodents go into a hibernation-like state found
Apr. 10, 2019 BDR News
Dive into BDR's intriguing research
Research on Hibernation?