Our team is developing the general synthetic methodology of short-lived PET molecular probes for promotion of PET molecular imaging science. With the objective of applying the potentials of organic chemistry to life science, we seek to realize the new synthetic methodology of PET molecular probes by using organometallic catalysts such as Pd, Rh, and Cu etc. As one of our main projects, we are striving toward introducing11C into carbon frameworks of bioactive small organic compounds by Pd0-mediated 11C-methylationsusing [11C]CH3I. These labeling methods provides groundbreaking synthesis for introducing the [11C]methyl group into a carbon framework in the very short time of 5 minutes. We are currently developing the stoichiometry-focused18F-labeling for medium molecules such asoligodeoxynucleotides by the application of Click chemistryand 11C-acetylation for large molecules such as proteins.
In addition, our team is responsible for production of PET radiopharmaceuticals for clinical PET study in official and private hospitals.
In the field of PET radiolabeling, the performance of the remote-controlled PET probe synthesizer is of key importance for realizing high quality and high yield in the synthesis of PET molecular probes. In this regard, we are also engaged in developing original PET probe synthesizers from the perspectives of not only safety and quick operation emphasized in labeling chemistry but also introducing advantages of experimental techniques ordinarily-used in organic chemistry. Thus, we seek to realize high quality original molecular probes and establish the probe library through developing the new labeling methodology.
- Development of PET-probe syntheses for drug candidates and novel labeling reactions
- Development of radiolabeling system based on organic chemistry
- Development of molecular probes associated with severe diseases such as cancer, inflammation, and neurological damage