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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

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Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

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News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Hisashi Doi | Laboratory for Labeling Chemistry

Publications

Kida, T., Takahashi, N., Mori, M. X., Sun, J. H., Oota, H., Nishino, K., Okauchi, T., Ochi, Y., Kano, D., Tateishi, U.,* Watanabe, Y., Cui,* Y., Mori, Y.,* Doi, H. “ N-Methylamide-Structured SB366791 Derivatives with High TRPV1 Antagonistic Activity: Toward PET Radiotracers to Visualize TRPV1” RSC Med. Chem 13, 1197–1204 (2022). doi: 10.1039/d2md00158f This paper made the front cover of the journal.

Doi H, Goto M, Sato Y. "Pd0-Mediated Cross-Coupling of [11C]Methyl Iodide with Carboxysilane for Synthesis of [11C]Acetic Acid and Its Active Esters: 11C-Acetylation of Small, Medium, and Large Molecules." European Journal of Organic Chemistry 2021(29), 3970-3979 (2021) doi: 10.1002/ejoc.202100638 This paper was selected as the front cover of the journal.

Takatani S, Tahara T, Tsuji M, et al. "Synthesis of L-[5-11 C]Leucine and L-α-[5-11C]Methylleucine via Pd0 -mediated 11C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging." ChemMedChem (2021) doi: 10.1002/cmdc.202100255 This paper won “Very Important Paper” (VIP) designation and was selected as the front cover of the journal. Additionally, this paper was introduced as a news article in the chemistry magazine ChemistryViews.

Nozaki, S., Nakatani, Y., Mawatari, A., Shibata, N., Hume, W. E., Hayashinaka, E., Wada, Y., Doi, H ., Watanabe, Y., " 18 F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation ", Sci. Rep. 9, 15718 (2019). (doi: 10.1038/s41598-019-52270-x)

Takeuchi, J., Kikukawa, T., Saito, H., Hasegawa, I., Takeda, A., Hatsuta, H., Kawabe, J., Wada, Y., Mawatari, A., Igesaka, A., Doi, H ., Watanabe, Y., Shimada, H., Kitamura, S., Higuchi, M., Suhara, T., Itoh, Y., "Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes", Open Biomed. Eng. J . 13, 55–66 (2019). (doi: 10.2174/1874120701913010055)

Watanabe, K., Nozaki, S., Goto, M., Kaneko, K., Hayashinaka, E., Irie, S., Nishiyama, A., Kasai, K., Fujii, K., Wada, Y., Mizuno, K., Mizuseki, K., Doi, H ., Watanabe, Y., "PET imaging of 11 C-labeled coenzyme Q 10 : Comparison of biodistribution between [ 11 C]ubiquinol-10 and [ 11 C]ubiquinone-10", Biochem. Biophys. Res. Commun ., 512, 611–615 (2019). (doi: 10.1016/j.bbrc.2019.03.073)

Goto, M., Nishiyama, A., Yamaguchi, T., Watanabe, K., Fujii, K., Watanabe, Y., Doi, H ., "Synthesis of 11 C-labeled ubiquinone and ubiquinol via Pd 0 -mediated rapid C -[ 11 C]methylation using [ 11 C]methyl iodide and 39-demethyl-39-(pinacolboryl)ubiquinone", J. Labelled Compd. Radiopharm . 62, 86–94 (2019). (doi: 10.1002/jlcr.3700) This research was adopted as the cover image and recognized as the top 10% most downloaded papers 2018–2019 in the journal.

Takahashi, K., Hosoya, T., Onoe, K., Takashima, T., Tanaka, M., Ishii, A., Nakatomi, Y., Tazawa, S., Takahashi, K., Doi, H ., Wada, Y., Watanabe, Y., "Association between aromatase in human brains and personality traits", Sci. Rep . 8, 16841 (2018). (doi: 10.1038/s41598-018-35065-4)

Nozaki, S., Mawatari, A., Nakatani, Y., Hayashinaka, E., Wada, Y., Nomura, Y., Kitayoshi, T., Akimoto, K., Ninomiya, S., Doi, H ., Watanabe, Y., "PET Imaging Analysis of Vitamin B1 Kinetics with [ 11 C]Thiamine and its Derivative [ 11 C]Thiamine Tetrahydrofurfuryl Disulfide in Rats", Mol. Imaging Biol . 20, 1001–1007 (2018). (doi: 10.1007/s11307-018-1186-y)

Doi, H ., Kida, T., Nishino, K., Nakatsuji, M., Sakamoto, S., Shimizu, S., Teraoka, Y., Tamura, Y., Kataoka, Y., Inui, T., "Solubility-Improved 10- O -Substituted SN-38 Derivatives with Antitumor Activity", ChemMedChem 12, 1715–1722 (2017). (doi: 10.1002/cmdc.201700454)

Morizane, A., Kikuchi, T., Hayashi, T., Mizuma, H., Takara, S., Doi, H ., Mawatari, A., Glasser, M. F., Shiina, T., Ishigaki, H., Itoh, Y., Okita, K., Yamasaki, E., Doi, D., Onoe, H., Ogasawara, K., Yamanaka, S., Takahashi, J., "MHC matching improves engraftment of iPSC-derived neurons in non-human primates", Nat. Commun . 8:385 (2017). (doi: 10.1038/s41467-017-00926-5)

Nozaki, S., Ozaki, N., Suzuki, S., Goto, M., Mawatari, A., Nakatani, Y., Hayashinaka, E., Doi, H ., Wada, Y., Watanabe, Y., "Development of diagnostic techniques for early rheumatoid arthritis using positron emission tomography with [ 11 C]PK11195 and [ 11 C]ketoprofen tracers", Mol. Imaging Biol . 19, 746–753 (2017). (doi: 10.1007/s11307-016-1039-5)

Yokoyama, C., Mawatari, A., Kawasaki, A., Takeda, C., Onoe, K., Doi, H ., Newman-Tancredi, A., Zimmer, L., Onoe, H., "Marmoset serotonin 5-HT 1A receptor mapping with a biased agonist PET probe 18 F-F13714: comparison with an antagonist tracer 18 F-MPPF in awake and anaesthetized state", Int. J. Neuropsychopharmacol . 19(12), 1–12 (2016). (doi: 10.1093/ijnp/pyw079)

Doi, H ., Sato, K., Shindou, H., Sumi, K., Koyama, H., Hosoya, T., Watanabe, Y., Ishii, S., Tsukada, H., Nakanishi, K., Suzuki, M., "Blood-Brain Barrier Permeability of Ginkgolide: Comparison of the Behavior of PET Probes 7α-[ 18 F]Fluoro- and 10- O -p-[ 11 C]Methylbenzyl Ginkgolide B in Monkey and Rat Brains", Bioorg. Med. Chem . 24, 5148–5157 (2016). (doi: 10.1016/j.bmc.2016.08.032)

Ohnishi, A., Senda, M., Yamane, T., Mikami, T., Nishida, H., Nishio, T., Akamatsu, G., Ikari, Y., Kimoto, S., Aita, K., Sasaki, M., Shinkawa, H., Yamato, Y., Shukuri, M., Mawatari, A., Doi, H ., Watanabe, Y., Onoe, H., "Exploratory human PET study of the effectiveness of 11 C-ketoprofen methyl ester, a potential biomarker of neuwoinflammatory processes in Alzheimer’s disease", Nucl. Med. Biol . 43, 438–444 (2016). (doi: 10.1016/j.nucmedbio. 2016.04.005)

Shukuri, M., Mawatari, A., Ohno, M., Suzuki, M., Doi, H ., Watanabe, Y., Onoe, H., "Detection of cyclooxygenase-1 in activated microglia during amyloid plaque progression: PET studies in Alzheimer’s disease model mice", J. Nucl. Med . 57, 291–296 (2016). (doi: 10.2967/jnumed.115.166116)

Tahara, T., Zhang, Z., Ohno, M., Hosaka, N., Hirao, Y., Suzuki, M., Doi, H ., Onoe, H., "A novel 11 C-labeled thymidine analog, [ 11 C]AZT, for tumor imaging by positron emission tomography", EJNMMI Research 5:45 (2015). (doi: 10.1186/s13550-015-0124-0)

Doi, H ., Mawatari, A., Kanazawa, M., Nozaki, S., Nomura, Y., Kitayoshi, T., Akimoto, K., Suzuki, M., Ninomiya, S., Watanabe, Y., "Synthesis of 11 C-Labeled Thiamine and Fursultiamine for In Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography", J. Org. Chem . 80, 6250–6258 (2015). (doi: 10.1021/acs.joc.5b00685)

Goto, M., Mizuma, H,. Wada, Y., Suzuki, M., Watanabe, Y., Onoe, H., Doi, H ., " 11 C-Labeled Capsaicin and Its In Vivo Molecular Imaging in Rats by Positron Emission Tomography", Food and Nutrition Sciences 6, 216–220 (2015). (doi: 10.4236/fns.2015.62022)

Han, C., Doi, H ., Kimura, J., Nakao, Y., Suzuki, M., " 11 C-Labeling of the C(1)-C(10) Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET Tracer", Int. J. Org. Chem . 4, 269–277 (2014). (doi: 10.4236/ijoc.2014.44029)

Zhang, Z., Doi, H ., Koyama, H., Watanabe, Y., Suzuki, M., "Efficient synthesis of [ 11 C]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C -[ 11 C]methylation", J. Label. Compd. Radiopharm . 57, 540–549 (2014). (doi: 10.1002/jlcr.3213)

Suzuki, M., Takashima-Hirano, M., Ishii, H., Watanabe, C., Sumi, K., Koyama, H., Doi, H ., "Synthesis of 11 C-labeled retinoic acid, [ 11 C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C -[ 11 C]methylation", Bioorg. Med. Chem. Lett ., 24, 3622–3625 (2014). (doi: 10.1016/j.bmcl.2014.05.041)

Ohnishi, A., Senda, M., Yamane, T., Sasaki, M., Nishio, T., Mikami, T., Ikari, Y., Nishida, H., Shukuri, M., Takashima, T., Mawatari, A., Doi, H ., Watanabe, Y., Onoe, H., "Human whole-body biodistribution and dosimetry of a new PET tracer, [ 11 C]ketoprofen methyl ester, for imagings of neuroinflammation", Nucl. Med. Biol . 41, 594–599 (2014). (doi: 10.1016/j.nucmedbio.2014.04.008)

Mukai, H., Ozaki, D., Cui, Y., Kuboyama, T., Yamato-Nagata, H., Onoe, K., Takahashi, M., Wada, Y., Imanishi, T., Kodama, T., Obika, S., Suzuki, M., Doi, H ., Watanabe, Y., "Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18 F-incorporated oligodeoxynucleotides", J. Control. Release . 180, 92–99 (2014). (doi: 10.1016/j.jconrel.2014.02.014)

Yamanaka, H., Yokoyama, C., Mizuma, H., Kurai, S., Finnema, S.J, Halldin, C., Doi, H ., Onoe, H., "A possible mechanism of the nucleus accumbens and ventral pallidum 5 HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques", Transl. Psychiatry 4, e342 (2014). (doi: 10.1038/tp.2013.112)

Takahashi, K., Hosoya, T., Onoe, K., Doi, H ., Nagata, H., Hiramatsu, T., Li, X., Watanabe, Y., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., Watanabe, Y., "[ 11 C]Cetrozole: an improved C -[ 11 C]methylated PET probe for aromataseimaging in the brain", J. Nucl. Med ., 55, 852–857 (2014).

Koyama, H., Doi, H ., Suzuki, M., "Evaluation of TlOH Effect for Pd 0 -Mediated Cross-Coupling of Methyl Iodide and Excess Boronic Acid Ester Toward Fabrication of [ 11 C]CH 3 -Incorporated PET Tracer", Int. J. Org. Chem ., 3, 220–223 (2013).

Kimura, T., Sako, T., Siqin, Hosokawa-Muto, J., Cui, Y., Wada, Y., Kataoka, Y., Doi, H ., Sakaguchi, S., Suzuki, M., Watanabe, Y., Kuwata, K., "Synthesis of 11 C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography", ChemMedChem , 8, 1035–1039 (2013). (doi: 10.1002/cmdc.201300167)

Takashima, T., Shingaki, T., Katayama, Y., Hayashinaka, E., Wada, Y., Kataoka, M., Ozaki, D., Doi, H ., Suzuki, M., Ishida, S., Hatanaka, K., Sugiyama, Y., Akai, S., Oku, N., Yamashita, S., Watanabe, Y., "Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: PET Imaging after Oral Administration of Non-absorbable Marker, [ 18 F]Deoxyfluoropoly(ethylene glycol)", Mol. Pharmaceutics , 10(6), 2261–2269 (2013).

Koyama, H., Zhang, Z., Ijuin, R., Siqin, Son, J., Hatta, Y., Ohta, M., Wakao, M., Hosoya, T., Doi, H ., Suzuki, M., "Pd 0 -mediated rapid coupling of methyl iodide with excess amounts of benzyl- and cinnamylboronic acid esters: efficient method for incorporation of positron-emitting 11 C radionuclide into organic frameworks by coupling between two sp 3 -hybridized carbons", RSC Advances , 3, 9391–9401 (2013).

Miyazaki, S., Minami, T., Mizuma, H., Kanazawa, M., Doi, H ., Matsumura, S., Lu, J., Onoe, H., Furuta, K., Suzuki, M., Ito, S., "The action site of the synthetic kainoid (2 S ,3 R ,4 R )-3-carboxymethyl-4- (4-methylphenylthio)pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain)", Eur. J. Pharmacol ., 710, 120–127 (2013). (doi: 10.1016/j.ejphar.2012.10.023)

Nakazawa, S., Yokoyama, C., Nishimura, fN., Horisawa, T., Kawasaki, A., Mizuma, H., Doi, H ., Onoe, H., "Evaluation of dopamine D 2 /D 3 and serotonin 5-HT 2 A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography", Psychopharmacology 225, 329–339 (2013). (doi: 10.1007/s00213-012-2815-9)

Doi, H ., Goto, M., Suzuki, M., "Pd 0 -Mediated Rapid C -[ 18 F]Fluoromethylation by the Cross-Coupling Reaction of a [ 18 F]Fluoromethyl Halide with an Arylboronic Acid Ester: Novel Method for the Synthesis of a 18 F-Labeled Molecular Probe for Positron Emission Tomography", Bull. Chem. Soc. Jpn . 85, 1233–1238 (2012). (doi:10.1246/bcsj.20120151)

Takashima, T., Kitamura, S., Wada, Y., Tanaka, M., Shigihara, Y., Ishii, H., Ijuin, R., Shiomi, S., Nakae, T., Watanabe, Yu., Cui Y., Doi, H ., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., Watanabe, Y., "PET imaging-based evaluation of hepatobiliary transport in human using 15R-[ 11 C]TIC-Me", J. Nucl. Med . 53, 741–748 (2012).

Kawasaki, T., Marumo, T., Shirakami, K., Mori, T., Doi, H ., Suzuki, M., Watanabe, Y., Chaki, S., Nakazato, A., Ago, Y., Hashimoto, H., Matsuda, T., Baba, A., Onoe H., "Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11 C-labeled 20-HETE synthase-specific inhibitor", J. Cereb. Blood Flow Metab ., 32, 1737–1746 (2012).

Suzuki, M., Takashima-Hirano, M., Koyama, H., Yamaoka, T., Sumi, K., Nagata, H., Hidaka, H., Doi, H ., "Efficient synthesis of [ 11 C]H-1152, a PET probe specific for Rho-kinases, highly potential targets in diagnostic medicine and drug development", Tetrahedron 68, 2336–2341 (2012). (doi: 10.1016/j.tet.2012.01.033)

Yashio, K., Katayama, Y., Takashima, T., Ishiguro N., Doi, H ., Suzuki, M., Wada, Y., Tamai, I., Watanabe, Y., "Synthesis of [ 11 C]uric acid, using [ 11 C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout", Bioorg. Med. Chem. Lett ., 22, 115–119 (2012).

Shukuri, M., Takashima-Hirano, M., Tokuda, K., Takashima, T., Matsumura, K., Inoue, O., Doi, H ., Suzuki, M., Watanabe, Y., Onoe, H., "In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11 C-Ketoprofen Methyl Ester", J. Nucl. Med ., 52(7), 1094–1101 (2011).

Takashima-Hirano, M., Tazawa, S., Takahashi, K., Doi, H ., Suzuki, M., "Efficient Synthesis of [ 11 C]Ramelteon as a Positron Emission Tomography Probe for Imaging Melatonin Receptors Involved in Circadian Rhythms", Chem. Pharm. Bull ., 59(8), 1062–1064 (2011).

Takahashi, K., Onoe, K., Doi, H ., Nagata, H., Yamagishi, G., Hosoya, T., Tamura, Y., Wada, Y., Yamanaka, H., Yokoyama, C., Mizuma, H., Takashima, T., Bergström, M., Onoe, H., Långström, B., Watanabe, Y., "Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [ 11 C]vorozole", NeuroReport , 22, 326–330 (2011).

Takashima-Hirano, M., Takashima, T., Katayama, Y., Wada, Y., Sugiyama, Y., Watanabe, Y., Doi, H ., Suzuki, M., "Efficient sequential synthesis of PET Probes of the COX-2 inhibitor [ 11 C]celecoxib and its major metabolite [ 11 C]SC-62807 and in vivo PET evaluation", Bioorg. Med. Chem ., 19, 2997–3004 (2011).

Koyama, H., Siqin, Zhang, Z., Sumi, K., Hatta, Y., Nagata, H., Doi, H ., Suzuki, M., "Highly efficient syntheses of [methyl- 11 C]thymidine and its analogue 4’-[methyl- 11 C]thiothymidine as nucleoside PET probes for cancer cell proliferation by Pd 0 -mediated rapid C -[ 11 C]methylation" Org. Biomol. Chem., 9, 4287–4294 (2011).

Kanazawa, M., Furuta, K., Doi, H ., Mori, T., Minami, T., Ito, S., Suzuki, M., "Synthesis of an acromelic acid A analog-based 11 C-labeled PET tracer for exploration of the site of action of acromelic acid A in allodynia induction", Bioorg. Med. Chem. Lett ., 21, 2017–2020 (2011).

Takashima, T., Yokoyama, C., Mizuma, H., Yamanaka, H., Wada, Y., Onoe, K., Nagata, H., Tazawa, S., Doi, H ., Takahashi, K., Morita, M., Kanai, M., Shibasaki, M., Kusuhara, H., Sugiyama, Y., Onoe, H., Watanabe, Y., "Developmental Changes in P-Glycoprotein Function in the Blood-Brain Barrier of Nonhuman Primates: PET Study with R- 11 C-Verapamil and 11 C-Oseltamivir", J. Nucl. Med . 52, 950–957 (2011).

Ozawa, M., Takahashi, K., Akazawa, K., Takashima, T., Nagata, H., Doi, H ., Hosoya, T., Wada, Y., Cui, Y., Kataoka, Y., Watanabe, Y., "PET of Aromatase in Gastric Parietal Cells Using 11 C-Vorozole", J. Nucl. Med . 52, 1964–1969 (2011).

Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H ., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., Hosoya, T., "Practical synthesis of precuesor of [N-methyl- 11 C]vorozole, an efficient PET tracer targeting aromatase in the brain", Bioorg. Med. Chem ., 19, 1464–1470 (2011).

Kuboyama, T., Nakahara, M., Yoshino, M., Cui, Y., Sako, T., Wada, Y., Imanishi, T., Obika, S., Watanabe, Y., Suzuki, M., Doi, H ., "Stoichiometry-Focused 18 F-Labeling of Alkyne-Substituted Oligodeoxynucleotides Using Azido([ 18 F]fluoromethyl)benzenes by Cu-Catalyzed Huisgen Reaction", Bioorg. Med. Chem ., 19, 249–255 (2011). (doi: 10.1016/j.bmc.2010.11.033)

Takashima, T., Nagata, H., Nakae, T., Cui, Y., Wada, Y., Kitamura, S., Doi, H ., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., Watanabe, Y., "Positron Emission Tomography Studies Using (15R)-16- m -[ 11 C]tolyl-17,18,19,20-tetranorisocarbacyclin Methyl Ester for the Evaluation of Hepatobiliary Transport", J. Pharmacol. Exp. Ther . 335, 314–323 (2010).

Takashima-Hirano, M., Shukuri, M., Takashima, T., Goto, M., Wada, Y., Watanabe, Y., Onoe, H., Doi, H ., Suzuki, M., "General Method for 11 C-Labeling of 2-Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression", Chem. Eur. J ., 16, 4250–4258 (2010).

Yokoyama, C., Yamanaka, H., Onoe, K., Kawasaki, A., Nagata, H., Shirakami, K., Doi, H ., Onoe, H., "Mapping of Serotonin Transporters by Positron Emission Tomography with [ 11 C]DASB in Conscious Common Marmosets: Comparison with Rhesus Monkeys", Synapse ,64(8), 594-601 (2010).

Suzuki, M., Sumi, K., Koyama, H., Siqin, Hosoya, T., Takashima-Hirano, M., Doi, H ., "Pd(0)-Mediated Rapid Coupling between Methyl Iodide and Hetero-Arylstannanes: an Efficient and General Method for the Incorporation of a Positron-Emitting 11 C Radionuclide into Heteroaromatic Frameworks", Chem. Eur. J ., 15,12489–12495 (2009).

Cui, Y., Takashima, T., Takashima-Hirano, M., Wada, Y., Shukuri, M., Tamura, Y., Doi, H ., Onoe, H., Kataoka, Y., Watanabe, Y., " 11 C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression", J. Nuc. Med ., 50, 1904–1911 (2009).

Doi, H ., Ban, I., Nonoyama, A., Sumi, K., Kuang, C., Hosoya, T., Tsukada, H., Suzuki, M., "Palladium(0)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic Acid Esters Useful for the Synthesis of [ 11 C]CH 3 —C- and [ 18 F]FCH 2 —C-Containing PET Tracers", Chem. Eur. J ., 15, 4165–4171 (2009).

Barletta, J., Karimi, F., Doi, H ., Långström, B., "Synthesis of diethyl [carbonyl- 11 C]malonate from [ 11 C]carbon monoxide by rhodium-promoted carbonylation and its application as a reaction intermediate", J. Label. Compd. Radiopharm . 49, 801-809 (2006).

Hosoya, T., Sumi, K., Doi, H ., Wakao, M., Suzuki, M., "Rapid methylation on carbon frameworks useful for the synthesis of 11 CH 3 -incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene", Org. Biomol. Chem ., 4, 410-415 (2006).

Doi, H ., Barletta, J., Suzuki, M., Noyori, R., Watanabe, Y., Långström, B., "Synthesis of 11 C-labelled N,N’-diphenylurea and ethyl phenylcarbamate by a rhodium-promoted carbonylation via [ 11 C]isocyanatobenzene using phenyl azide and [ 11 C]carbon monoxide", Org. Biomol. Chem ., 2, 3063–3066 (2004). (doi: 10.1039/B409294E)

Hosoya, T., Wakao, M., Kondo, Y., Doi, H ., Suzuki, M., "Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11 CH 3 -labeled PET tracers with 1-propynyl group", Org. Biomol. Chem ., 2, 24–27 (2004).

Suzuki, M., Doi, H ., Kato, K., Björkman, M., Långström, B., Watanabe, Y., Noyori, R., "Rapid Methylation for the Synthesis of a 11 C-Labeled Tolylisocarbacyclin Imaging the IP 2 Receptor in a Living Human Brain", Tetrahedron , 56, 8263–8273 (2000).

Björkman, M., Doi, H ., Resul, B., Suzuki, M., Noyori, R., Watanabe, Y., Långström, B., "Synthesis of a 11 C-Labelled Prostaglandin F2α Analogue Using an Improved Method for Stille Reactions with [ 11 C]Methyl Iodide", J. Labelled Compd. Radiopharm ., 43, 1327–1334 (2000).

Björkman, M., Andersson, Y., Doi, H ., Kato, K., Suzuki, M., Noyori, R., Watanabe, Y., Långström, B., "Synthesis of 11 C/ 13 C-labelled Prostacyclins", Acta Chem. Scand ., 52, 635–640 (1998).

Mori, T., Taniguchi, M., Suzuki, F., Doi, H ., Oku, A., "Ring-enlargement reaction of alkylidenecarbenes bearing a cyclic ether or acetal group. Formation of medium-sized cyclic enol ethers or dienol ethers via bicycloalkenyloxonium ylides", J. Chem. Soc., Perkin Trans . 1, 3623-3628 (1998).

Suzuki, M., Doi, H ., Björkman, M., Andersson, Y., Långström, B., Watanabe, Y., Noyori, R., "Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Synthesis of 11 CH 3 -Labeled PET Tracers.", Chem. Eur. J ., 3, 2039–2042 (1997). (doi: 10.1002/chem19970031219)

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