logomark
Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

News | Laboratory for Labeling Chemistry

Research and other news from the Laboratory for Labeling Chemistry. Please also see our publications list.

Oct 19, 2022 Research

N-Methylamide-Structured SB366791 Derivatives with High TRPV1 Antagonistic Activity: Toward PET Radiotracers to Visualize TRPV1”Kida, T., Takahashi, N., Mori, M. X., et al.

This paper made the front cover of the journal, RSC Med. Chem., 13

From the medicinal chemistry perspective to address the in vivo metabolism issues of SB366791 as a benchmark TRPV1 antagonist, we developed novel N-methylamide-structured SB366791 derivatives which showed higher antagonistic activity than SB366791. 11C- and 18F-Labeled radiotracers of these derivatives were synthesized, and PET imaging studies using rats were performed.

RSC Med. Chem., 13

Jun 15, 2022 Research

"Synthesis of L-[5-11C]Leucine and L-α-[5-11C]Methylleucine via Pd0-mediated 11C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging" Takatani S, Tahara T, Tsuji M, et al.

This paper won “Very Important Paper” (VIP) designation and was selected as the front cover of the journal. Additionally, this paper was introduced as a news article in the chemistry magazine ChemistryViews.

Image of chemical reaction formula and application to humans

Aug 6, 2021 Research

"Pd0-Mediated Cross-Coupling of [11C]Methyl Iodide with Carboxysilane for Synthesis of [11C]Acetic Acid and Its Active Esters: 11C-Acetylation of Small, Medium, and Large Molecules." Doi H, Goto M, Sato Y. 

This paper was selected as the front cover of the journal.

The cover of the jjournal

PAGE
TOP