News | Laboratory for Labeling Chemistry

Oct 19, 2022 Research

Toward PET Radiotracers to Visualize TRPV1

“N-Methylamide-Structured SB366791 Derivatives with High TRPV1 Antagonistic Activity: Toward PET Radiotracers to Visualize TRPV1”Kida, T., Takahashi, N., Mori, M. X., et al.

This paper made the front cover of the journal, RSC Med. Chem., 13

From the medicinal chemistry perspective to address the in vivo metabolism issues of SB366791 as a benchmark TRPV1 antagonist, we developed novel N-methylamide-structured SB366791 derivatives which showed higher antagonistic activity than SB366791. 11C- and 18F-Labeled radiotracers of these derivatives were synthesized, and PET imaging studies using rats were performed.

Jun 15, 2022 Research

Efficient syntheses of ¹¹C-labeled leucines  for tumor PET imaging

"Synthesis of L-[5-¹¹C]Leucine and L-α-[5-¹¹C]Methylleucine via Pd⁰-mediated ¹¹C-Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging" Takatani S, Tahara T, Tsuji M, et al.

This paper won “Very Important Paper” (VIP) designation and was selected as the front cover of the journal. Additionally, this paper was introduced as a news article in the chemistry magazine ChemistryViews.

Aug 6, 2021 Research

A novel synthetic method for [¹¹C]acetic and usuful for ¹¹C-acetylation radiolabeling

"Pd⁰-Mediated Cross-Coupling of [¹¹C]Methyl Iodide with Carboxysilane for Synthesis of [¹¹C]Acetic Acid and Its Active Esters: ¹¹C-Acetylation of Small, Medium, and Large Molecules." Doi H, Goto M, Sato Y. 

This paper was selected as the front cover of the journal.