
当研究室では、コンピュータの素子作製などに使われる半導体加工技術により作製した、髪の毛や蚊の針の太さ(10~100 μm)と同じかそれ以下のきわめて微小な構造体や流路などのデバイスを、化学やバイオ分野に展開することで、細胞や分子の精密な操作を可能とし、バイオ実験の集積化・次世代化を推進しています。また、未来の理想の機械のモデルを示すことを目標に、現在の科学技術では再現が難しい、生物の細胞や組織の特異的な機能に着目し、これと微細加工技術を融合した新原理の機械の創成に取り組んでいます。
研究テーマ
- バイオ実験の集積化・次世代化
- 生体機能利用型革新的原理のマイクロ・ナノデバイスの開発
主要論文
Aishan Y, Yalikun Y, Shen Y, et al.
A chemical micropump actuated by self-oscillating polymer gel.
Sensors and Actuators B: Chemical
337, 129769 (2021)
doi: 10.1016/j.snb.2021.129769
Yuan Y, Yalikun Y, Amaya S, et al.
Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching.
Sensors and Actuators A: Physical
321, 112604 (2021)
doi: 10.1016/j.sna.2021.112604
Funano SI, Ota N, Tanaka Y.
A simple and reversible glass-glass bonding method to construct a microfluidic device and its application for cell recovery.
Lab on a chip
(2021)
doi: 10.1039/d1lc00058f
Yamamoto K, Ota N, Tanaka Y.
Nanofluidic Devices and Applications for Biological Analyses.
Analytical chemistry
93(1), 332-349 (2021)
doi: 10.1021/acs.analchem.0c03868
Funano S, Tanaka N, Amaya S, et al.
Movement tracing and analysis of benthic sting ray (Dasyatis akajei) and electric ray (Narke japonica) toward seabed exploration.
SN Applied Sciences
2, 2142 (2020)
doi: 10.1007/s42452-020-03967-6
Abulaiti M, Yalikun Y, Murata K, et al.
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
Scientific Reports
10, 19201 (2020)
doi: 10.1038/s41598-020-76062-w
Shen Y, Yalikun Y, Aishan Y, et al.
Area cooling enables thermal positioning and manipulation of single cells.
Lab on a chip
20(20), 3733-3743 (2020)
doi: 10.1039/d0lc00523a
Funano SI, Tone D, Ukai H, et al.
Rapid and easy-to-use ES cell manipulation device with a small groove near culturing wells.
BMC research notes
13(1), 453 (2020)
doi: 10.1186/s13104-020-05294-w
Shen Y, Tanaka N, Yamazoe H, et al.
Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin.
PLoS ONE
15(5), e0232518 (2020)
doi: 10.1371/journal.pone.0232518
Katayama R, Tanaka N, Takagi Y, et al.
Characterization of the Hydration Process of Phospholipid-Mimetic Polymers Using Air-Injection-Mediated Liquid Exclusion Methods.
Langmuir : the ACS journal of surfaces and colloids
36(20), 5626-5632 (2020)
doi: 10.1021/acs.langmuir.0c00953
Aishan Y, Yalikun Y, Amaya S, et al.
Thin glass micro-dome structure based microlens fabricated by accurate thermal expansion of microcavities.
Applied Physics Letters
115, 263501 (2019)
doi: 10.1063/1.5123186
Ota N, Kanda GN, Moriguchi H, et al.
A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-Term Culturing of Explanted Tissues.
Analytical Sciences
35(10), 1141-1147 (2019)
doi: 10.2116/analsci.19P099
Kawai T, Ota N, Okada K, et al.
Ultrasensitive single cell metabolomics by capillary electrophoresis–mass spectrometry with a thin-walled tapered emitter and large-volume dual sample preconcentration.
Analytical Chemistry
91, 10564-10572 (2019)
doi: 10.1021/acs.analchem.9b01578
Ota N, Yonamine Y, Asai T, et al.
Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis.
Analytical chemistry
91(15), 9631-9639 (2019)
doi: 10.1021/acs.analchem.9b01007
Tanaka Y, Funano SI, Noguchi Y, et al.
A valve powered by earthworm muscle with both electrical and 100% chemical control.
Scientific reports
9(1), 8042 (2019)
doi: 10.1038/s41598-019-44116-3
Tanaka N, Kogo T, Hirai N, et al.
In-situ detection based on the biofilm hydrophilicity for environmental biofilm formation.
Scientific reports
9(1), 8070 (2019)
doi: 10.1038/s41598-019-44167-6
Tanaka N, Yamashita T, Yalikun Y, et al.
An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers.
Sensors and Actuators B: Chemical
293, 256-264 (2019)
doi: 10.1016/j.snb.2019.04.087
Shen Y, Yalikun Y, Tanaka Y.
Recent advances in microfluidic cell sorting systems.
Sensors and Actuators B: Chemical
282, 268-281 (2019)
doi: 10.1016/j.snb.2018.11.025
Ota N, Yalikun Y, Tanaka N, et al.
Simple Isolation of Single Cell: Thin Glass Microfluidic Device for Observation of Isolated Single Euglena gracilis Cells.
Analytical sciences
35(5), 577-583 (2019)
doi: 10.2116/analsci.18P568
Ota N, Yalikun Y, Suzuki T, et al.
Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.
Royal Society Open Science
6, 181776 (2019)
doi: 10.1098/rsos.181776
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