チームリーダー（2018年4月〜2022年8月）
田中陽* Ph.D. (Eng.)
チームリーダー（兼務、2022年9月〜）
西田栄介 Ph.D.

集積バイオデバイス研究チーム

[2023年3月終了]

*現在の連絡先： yo.tanaka[at]a.riken.jp

[at]を@に変えてください

概要
主要論文
ニュース

微細デバイス技術で生物学を革新する

当研究室では、コンピュータの素子作製などに使われる半導体加工技術により作製した、髪の毛や蚊の針の太さ（10～100 μm）と同じかそれ以下のきわめて微小な構造体や流路などのデバイスを、化学やバイオ分野に展開することで、細胞や分子の精密な操作を可能とし、バイオ実験の集積化・次世代化を推進しています。また、未来の理想の機械のモデルを示すことを目標に、現在の科学技術では再現が難しい、生物の細胞や組織の特異的な機能に着目し、これと微細加工技術を融合した新原理の機械の創成に取り組んでいます。

研究テーマ

バイオ実験の集積化・次世代化
生体機能利用型革新的原理のマイクロ・ナノデバイスの開発

主要論文

Tanaka Y, Amaya S, Funano SI, et al.
A pressure driven electric energy generator exploiting a micro- to nano-scale glass porous filter with ion flow originating from water.
Scientific Reports 12(1), 16827 (2022) doi: 10.1038/s41598-022-21069-8

Tanaka Y, Ma D, Amaya S, et al.
Anhydrobiotic chironomid larval motion-based multi-sensing microdevice for the exploration of survivable locations.
iScience 25(8), 104639 (2022) doi: 10.1016/j.isci.2022.104639

Aishan Y, Funano SI, Sato A, et al.
Bio-actuated microvalve in microfluidics using sensing and actuating function of Mimosa pudica.
Scientific Reports 12(1), 7653 (2022) doi: 10.1038/s41598-022-11637-3

Aishan Y, Yalikun Y, Shen Y, et al.
A chemical micropump actuated by self-oscillating polymer gel.
Sensors and Actuators B: Chemical 337, 129769 (2021) doi: 10.1016/j.snb.2021.129769

Yuan Y, Yalikun Y, Amaya S, et al.
Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching.
Sensors and Actuators A: Physical 321, 112604 (2021) doi: 10.1016/j.sna.2021.112604

Funano SI, Ota N, Tanaka Y.
A simple and reversible glass-glass bonding method to construct a microfluidic device and its application for cell recovery.
Lab on a chip (2021) doi: 10.1039/d1lc00058f

Yamamoto K, Ota N, Tanaka Y.
Nanofluidic Devices and Applications for Biological Analyses.
Analytical chemistry 93(1), 332-349 (2021) doi: 10.1021/acs.analchem.0c03868

Funano S, Tanaka N, Amaya S, et al.
Movement tracing and analysis of benthic sting ray (Dasyatis akajei) and electric ray (Narke japonica) toward seabed exploration.
SN Applied Sciences 2, 2142 (2020) doi: 10.1007/s42452-020-03967-6

Abulaiti M, Yalikun Y, Murata K, et al.
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
Scientific Reports 10, 19201 (2020) doi: 10.1038/s41598-020-76062-w

Shen Y, Yalikun Y, Aishan Y, et al.
Area cooling enables thermal positioning and manipulation of single cells.
Lab on a chip 20(20), 3733-3743 (2020) doi: 10.1039/d0lc00523a

Funano SI, Tone D, Ukai H, et al.
Rapid and easy-to-use ES cell manipulation device with a small groove near culturing wells.
BMC research notes 13(1), 453 (2020) doi: 10.1186/s13104-020-05294-w

Shen Y, Tanaka N, Yamazoe H, et al.
Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin.
PLoS ONE 15(5), e0232518 (2020) doi: 10.1371/journal.pone.0232518

Katayama R, Tanaka N, Takagi Y, et al.
Characterization of the Hydration Process of Phospholipid-Mimetic Polymers Using Air-Injection-Mediated Liquid Exclusion Methods.
Langmuir : the ACS journal of surfaces and colloids 36(20), 5626-5632 (2020) doi: 10.1021/acs.langmuir.0c00953

Aishan Y, Yalikun Y, Amaya S, et al.
Thin glass micro-dome structure based microlens fabricated by accurate thermal expansion of microcavities.
Applied Physics Letters 115, 263501 (2019) doi: 10.1063/1.5123186

Ota N, Kanda GN, Moriguchi H, et al.
A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-Term Culturing of Explanted Tissues.
Analytical Sciences 35(10), 1141-1147 (2019) doi: 10.2116/analsci.19P099

Kawai T, Ota N, Okada K, et al.
Ultrasensitive single cell metabolomics by capillary electrophoresis–mass spectrometry with a thin-walled tapered emitter and large-volume dual sample preconcentration.
Analytical Chemistry 91, 10564-10572 (2019) doi: 10.1021/acs.analchem.9b01578

Ota N, Yonamine Y, Asai T, et al.
Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis.
Analytical chemistry 91(15), 9631-9639 (2019) doi: 10.1021/acs.analchem.9b01007

Tanaka Y, Funano SI, Noguchi Y, et al.
A valve powered by earthworm muscle with both electrical and 100% chemical control.
Scientific reports 9(1), 8042 (2019) doi: 10.1038/s41598-019-44116-3

Tanaka N, Kogo T, Hirai N, et al.
In-situ detection based on the biofilm hydrophilicity for environmental biofilm formation.
Scientific reports 9(1), 8070 (2019) doi: 10.1038/s41598-019-44167-6

Tanaka N, Yamashita T, Yalikun Y, et al.
An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers.
Sensors and Actuators B: Chemical 293, 256-264 (2019) doi: 10.1016/j.snb.2019.04.087

Shen Y, Yalikun Y, Tanaka Y.
Recent advances in microfluidic cell sorting systems.
Sensors and Actuators B: Chemical 282, 268-281 (2019) doi: 10.1016/j.snb.2018.11.025

Ota N, Yalikun Y, Tanaka N, et al.
Simple Isolation of Single Cell: Thin Glass Microfluidic Device for Observation of Isolated Single Euglena gracilis Cells.
Analytical sciences 35(5), 577-583 (2019) doi: 10.2116/analsci.18P568

Ota N, Yalikun Y, Suzuki T, et al.
Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.
Royal Society Open Science 6, 181776 (2019) doi: 10.1098/rsos.181776