Team Leader (Apr. 2018 - Aug. 2022)
Yo Tanaka* Ph.D. (Eng.)
Team Leader (Sep. 2022 - )
Eisuke Nishida Ph.D.

Laboratory for Integrated Biodevice

[Closed Mar. 2023]

*Current email address : yo.tanaka[at]a.riken.jp

Please replace [at] with @.

Overview
Selected Publications
News

Innovating biology by microdevices

This laboratory aims to promote integration and sophistication of biological experiments using micro structures and channels based on semiconductor fabrication methods. These sizes are near the size of hair or mosquito needle width (10～100 μm) or less. By exploiting these devices to chemical or biological fields, precise cell or molecular handling can be realized. Furthermore, our group focuses on unique functions of cells or tissue of living creatures. By combining this with microfabrication technology, we aim to new functional devices and propose future ideal machine models.

Research Theme

Integrated and sophisticated biological experiments
Novel micro- and nano-size biological devices

Selected Publications

Tanaka Y, Amaya S, Funano SI, et al.
A pressure driven electric energy generator exploiting a micro- to nano-scale glass porous filter with ion flow originating from water.
Scientific Reports 12(1), 16827 (2022) doi: 10.1038/s41598-022-21069-8

Tanaka Y, Ma D, Amaya S, et al.
Anhydrobiotic chironomid larval motion-based multi-sensing microdevice for the exploration of survivable locations.
iScience 25(8), 104639 (2022) doi: 10.1016/j.isci.2022.104639

Aishan Y, Funano SI, Sato A, et al.
Bio-actuated microvalve in microfluidics using sensing and actuating function of Mimosa pudica.
Scientific Reports 12(1), 7653 (2022) doi: 10.1038/s41598-022-11637-3

Aishan Y, Yalikun Y, Shen Y, et al.
A chemical micropump actuated by self-oscillating polymer gel.
Sensors and Actuators B: Chemical 337, 129769 (2021) doi: 10.1016/j.snb.2021.129769

Yuan Y, Yalikun Y, Amaya S, et al.
Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching.
Sensors and Actuators A: Physical 321, 112604 (2021) doi: 10.1016/j.sna.2021.112604

Funano SI, Ota N, Tanaka Y.
A simple and reversible glass-glass bonding method to construct a microfluidic device and its application for cell recovery.
Lab on a chip (2021) doi: 10.1039/d1lc00058f

Yamamoto K, Ota N, Tanaka Y.
Nanofluidic Devices and Applications for Biological Analyses.
Analytical chemistry 93(1), 332-349 (2021) doi: 10.1021/acs.analchem.0c03868

Funano S, Tanaka N, Amaya S, et al.
Movement tracing and analysis of benthic sting ray (Dasyatis akajei) and electric ray (Narke japonica) toward seabed exploration.
SN Applied Sciences 2, 2142 (2020) doi: 10.1007/s42452-020-03967-6

Abulaiti M, Yalikun Y, Murata K, et al.
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
Scientific Reports 10, 19201 (2020) doi: 10.1038/s41598-020-76062-w

Shen Y, Yalikun Y, Aishan Y, et al.
Area cooling enables thermal positioning and manipulation of single cells.
Lab on a chip 20(20), 3733-3743 (2020) doi: 10.1039/d0lc00523a

Funano SI, Tone D, Ukai H, et al.
Rapid and easy-to-use ES cell manipulation device with a small groove near culturing wells.
BMC research notes 13(1), 453 (2020) doi: 10.1186/s13104-020-05294-w

Shen Y, Tanaka N, Yamazoe H, et al.
Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin.
PLoS ONE 15(5), e0232518 (2020) doi: 10.1371/journal.pone.0232518

Katayama R, Tanaka N, Takagi Y, et al.
Characterization of the Hydration Process of Phospholipid-Mimetic Polymers Using Air-Injection-Mediated Liquid Exclusion Methods.
Langmuir : the ACS journal of surfaces and colloids 36(20), 5626-5632 (2020) doi: 10.1021/acs.langmuir.0c00953

Aishan Y, Yalikun Y, Amaya S, et al.
Thin glass micro-dome structure based microlens fabricated by accurate thermal expansion of microcavities.
Applied Physics Letters 115, 263501 (2019) doi: 10.1063/1.5123186

Ota N, Kanda GN, Moriguchi H, et al.
A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-Term Culturing of Explanted Tissues.
Analytical Sciences 35(10), 1141-1147 (2019) doi: 10.2116/analsci.19P099

Kawai T, Ota N, Okada K, et al.
Ultrasensitive single cell metabolomics by capillary electrophoresis–mass spectrometry with a thin-walled tapered emitter and large-volume dual sample preconcentration.
Analytical Chemistry 91, 10564-10572 (2019) doi: 10.1021/acs.analchem.9b01578

Ota N, Yonamine Y, Asai T, et al.
Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis.
Analytical chemistry 91(15), 9631-9639 (2019) doi: 10.1021/acs.analchem.9b01007

Tanaka Y, Funano SI, Noguchi Y, et al.
A valve powered by earthworm muscle with both electrical and 100% chemical control.
Scientific reports 9(1), 8042 (2019) doi: 10.1038/s41598-019-44116-3

Tanaka N, Kogo T, Hirai N, et al.
In-situ detection based on the biofilm hydrophilicity for environmental biofilm formation.
Scientific reports 9(1), 8070 (2019) doi: 10.1038/s41598-019-44167-6

Tanaka N, Yamashita T, Yalikun Y, et al.
An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers.
Sensors and Actuators B: Chemical 293, 256-264 (2019) doi: 10.1016/j.snb.2019.04.087

Shen Y, Yalikun Y, Tanaka Y.
Recent advances in microfluidic cell sorting systems.
Sensors and Actuators B: Chemical 282, 268-281 (2019) doi: 10.1016/j.snb.2018.11.025

Ota N, Yalikun Y, Tanaka N, et al.
Simple Isolation of Single Cell: Thin Glass Microfluidic Device for Observation of Isolated Single Euglena gracilis Cells.
Analytical sciences 35(5), 577-583 (2019) doi: 10.2116/analsci.18P568

Ota N, Yalikun Y, Suzuki T, et al.
Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.
Royal Society Open Science 6, 181776 (2019) doi: 10.1098/rsos.181776