Laboratory for Integrated Biodevice

Research Summary

This laboratory aims to promote integration and sophistication of biological experiments using micro structures and channels based on semiconductor fabrication methods. These sizes are near the size of hair or mosquito needle width (10～100 μm) or less. By exploiting these devices to chemical or biological fields, precise cell or molecular handling can be realized. Furthermore, our group focuses on unique functions of cells or tissue of living creatures. By combining this with microfabrication technology, we aim to new functional devices and propose future ideal machine models.

Research Theme

• Integrated and sophisticated biological experiments
• Novel micro- and nano-size biological devices

Main Publications List

• Funano S, Ota N, Tanaka Y.
  A simple and reversible glass-glass bonding method to construct a microfluidic device and its application for cell recovery.
  Lab on a Chip doi: 10.1039/d1lc00058f
• Aishan Y, Yalikun Y, Shen Y, et al,
  A chemical micropump actuated by self-oscillating polymer gel.
  Sensors and Actuators B: Chemical 337, 129769 (2021) doi: 10.1016/j.snb.2021.129769
• Yuan Y, Yalikun Y, Amaya S, et al.
  Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching.
  Sensors and Actuators A: Physical 321, 112604 (2021) doi: 10.1016/j.sna.2021.112604
• Funano S, Tanaka N, Amaya S, et al.
  Movement tracing and analysis of benthic sting ray (Dasyatis akajei) and electric ray (Narke japonica) toward seabed exploration.
  SN Applied Sciences 2:2142 (2020) doi: 10.1007/s42452-020-03967-6
• Abulaiti M, Yalikun Y, Murata K, et al.
  Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
  Scientific Reports 10:19201 (2020) doi: 10.1038/s41598-020-76062-w
• Yamamoto K, Ota N, Tanaka Y.
  Nanofluidic devices and applications for biological analyses
  Analytical Chemistry (2020) doi: 10.1021/acs.analchem.0c03868
• Funano S, Tone D, Ukai H, et al.
  Rapid and easy-to-use ES cell manipulation device with a small groove near culturing wells.
  BMC Research Notes doi: 10.1186/s13104-020-05294-w
• Yigang Shen Y, Yalikun Y, Aishan Y, et al.
  Area cooling enables thermal positioning and manipulation of single cells.
  Lab on a Chip (2020) doi: 10.1039/D0LC00523A
• Shen Y, Tanaka N, Yamazoe H, et al.
  Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin.
  PLoS ONE 15(5):e0232518 (2020) doi: 10.1371/journal.pone.0232518
• Katayama R, Tanaka N, Takagi Y, et al.
  Characterization of Hydration Process of Phospholipid-Mimetic Polymers Using the Air Injection-Mediated Liquid Exclusion Methods.
  Langmuir (2020) doi: 10.1021/acs.langmuir.0c00953
• Aishan Y, Yalikun Y, Amaya S, et al.
  Thin glass micro-dome structure based microlens fabricated by accurate thermal expansion of microcavities
  Applied Physics Letters 115, 263501 (2019) doi: 10.1063/1.5123186
• Ota N, Kanda GN, Moriguchi H, et al.
  A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-Term Culturing of Explanted Tissues.
  Analytical Sciences 35(10). 1141-1147 (2019) doi: 10.2116/analsci.19P099
• Kawai T, Ota N, Okada K, et al.
  Ultrasensitive single cell metabolomics by capillary electrophoresis–mass spectrometry with a thin-walled tapered emitter and large-volume dual sample preconcentration.
  Analytical Chemistry 91, 10564–10572 (2019) doi: 10.1021/acs.analchem.9b01578
• Ota N, Yonamine Y, Asai T, et al.
  Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis.
  Analytical chemistry 91(15). 9631-9639 (2019) doi: 10.1021/acs.analchem.9b01007
• Tanaka Y, Funano SI, Noguchi Y, et al.
  A valve powered by earthworm muscle with both electrical and 100% chemical control.
  Scientific reports 9(1). 8042 (2019) doi: 10.1038/s41598-019-44116-3
• Tanaka N, Kogo T, Hirai N, et al.
  In-situ detection based on the biofilm hydrophilicity for environmental biofilm formation.
  Scientific reports 9(1). 8070 (2019) doi: 10.1038/s41598-019-44167-6
• Tanaka N, Yamashita T, Yalikun Y, et al.
  An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers.
  Sensors and Actuators B: Chemical 293. 256-264 (2019) doi: 10.1016/j.snb.2019.04.087
• Shen Y, Yalikun Y, Tanaka Y.
  Recent advances in microfluidic cell sorting systems
  Sensors and Actuators B: Chemical 282. 268-281 (2019) doi: 10.1016/j.snb.2018.11.025
• Ota N, Yalikun Y, Tanaka N, et al.
  Simple Isolation of Single Cell: Thin Glass Microfluidic Device for Observation of Isolated Single Euglena gracilis Cells.
  Analytical sciences 35(5). 577-583 (2019) doi: 10.2116/analsci.18P568
• Ota N, Yalikun Y, Suzuki T, et al.
  Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.
  Royal Society Open Science 6. 181776 (2019) doi: 10.1098/rsos.181776

All Publications

• 2021/04/01 Research A soft chemical micropump actuated by self-oscillating polymer gel
• 2020/12/08 Research Can sting rays and electric rays help us map the ocean floor?
• 2019/11/15 Research Detecting the metabolites of a single cell
• 2019/10/11 Research Analyzing the metabolites produced by single motile cells
• 2019/10/10 Research Brain tissue kept alive for weeks on an artificial membrane
• 2019/07/25 Research Toward micro-hearts: tiny pumps driven by self-organizing cardiomyocytes
• 2019/07/08 Research Cyborg-like microchip valve driven by earthworm muscle