チームリーダー
萩原 将也
Ph.D.
生体模倣システム理研白眉研究チーム
E-mail masaya.hagiwara [at] riken.jp
[at]を@に変えてください
当研究室では細胞周りの微小環境を制御した実験プラットフォームを構築することで、創薬や発生メカニズム解明に繋がる生体機能を体外で再現するための研究を行っています。特に気管支にターゲットを当て、あの複雑な形状がどのようにして自律的に形づくることができるのか、実験とモデルをフィードバックしながら体外で人為的に誘導することで明らかにしようとしています。また、組織間の連関が解析可能な臓器チップの開発も同時に行っており、従来の動物実験を凌ぐ実験解析系の構築を目指しています。
主要論文
Koh I, Hagiwara M.
Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation.
Communications Biology
6(1), 299 (2023)
doi: 10.1038/s42003-023-04694-5
Suthiwanich K, Hagiwara M.
Localization of Multiple Hydrogels with MultiCUBE Platform Spatially Guides 3D Tissue Morphogenesis In Vitro
Advanced Materials Technologies
8(4), 2201660 (2023)
doi: 10.1002/admt.202201660
Takano A, Koh I, Hagiwara M.
3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device.
Micromachines
13(2), 156 (2022)
doi: 10.3390/mi13020156
Hagiwara M, Maruyama H, Akiyama M, et al.
Weakening of resistance force by cell-ECM interactions regulate cell migration directionality and pattern formation.
Communications Biology
4(1), 808 (2021)
doi: 10.1038/s42003-021-02350-4
Hagiwara M, Koh I.
Engineering approaches to control and design the in vitro environment towards the reconstruction of organs.
Development, Growth & Differentiation
62(3), 158-166 (2020)
doi: 10.1111/dgd.12647
Hagiwara M, Nobata R, Kawahara T.
Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations.
Journal of Visualized Experiments
(2019)
doi: 10.3791/59214
Hagiwara M, Nakase I.
Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells.
Biochemical and Biophysical Research Communications
507(1-4), 297-303 (2018)
doi: 10.1016/j.bbrc.2018.11.028
Hagiwara M, Nobata R, Kawahara T.
High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations.
Integrative Biology
10(5), 306-312 (2018)
doi: 10.1039/c8ib00032h
Hagiwara M, Nobata R, Kawahara T.
Large Scale Imaging by Fine Spatial Alignment of Multi-Scanning Data with Gel Cube Device
Applied Sciences
8(2), 235 (2018)
doi: 10.3390/app8020235
Hagiwara M, Maruta N, Marumoto M.
In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells.
Tissue Engineering. Part C, Methods
23(6), 323-332 (2017)
doi: 10.1089/ten.TEC.2017.0126
Hagiwara M.
An in vitro-in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells.
Integrative Biology
8(8), 861-868 (2016)
doi: 10.1039/c6ib00073h
Hagiwara M, Kawahara T, Nobata R.
Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations.
Advanced Healthcare Materials
5(13), 1566-1571 (2016)
doi: 10.1002/adhm.201600167
メンバー
萩原 将也
理研白眉研究チームリーダー
VADIVELU Raja Kumar
基礎科学特別研究員
KOH Isabel Siew Yin
特別研究員
NGO Yen Xuan
特別研究員
木下 聖子
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