Team Leader
Masaya Hagiwara
Ph.D.
Human Biomimetic System RIKEN Hakubi Research Team
LocationKobe / Integrated Innovation Bldg.
E-mailmasaya.hagiwara [at] riken.jp
Please replace [at] with @.
The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets.The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.
Selected Publications
Koh I, Hagiwara M.
Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation.
Communications Biology
6(1), 299 (2023)
doi: 10.1038/s42003-023-04694-5
Suthiwanich K, Hagiwara M.
Localization of Multiple Hydrogels with MultiCUBE Platform Spatially Guides 3D Tissue Morphogenesis In Vitro
Advanced Materials Technologies
8(4), 2201660 (2023)
doi: 10.1002/admt.202201660
Takano A, Koh I, Hagiwara M.
3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device.
Micromachines
13(2), 156 (2022)
doi: 10.3390/mi13020156
Hagiwara M, Maruyama H, Akiyama M, et al.
Weakening of resistance force by cell-ECM interactions regulate cell migration directionality and pattern formation.
Communications Biology
4(1), 808 (2021)
doi: 10.1038/s42003-021-02350-4
Hagiwara M, Koh I.
Engineering approaches to control and design the in vitro environment towards the reconstruction of organs.
Development, Growth & Differentiation
62(3), 158-166 (2020)
doi: 10.1111/dgd.12647
Hagiwara M, Nobata R, Kawahara T.
Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations.
Journal of Visualized Experiments
(2019)
doi: 10.3791/59214
Hagiwara M, Nakase I.
Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells.
Biochemical and Biophysical Research Communications
507(1-4), 297-303 (2018)
doi: 10.1016/j.bbrc.2018.11.028
Hagiwara M, Nobata R, Kawahara T.
High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations.
Integrative Biology
10(5), 306-312 (2018)
doi: 10.1039/c8ib00032h
Hagiwara M, Nobata R, Kawahara T.
Large Scale Imaging by Fine Spatial Alignment of Multi-Scanning Data with Gel Cube Device
Applied Sciences
8(2), 235 (2018)
doi: 10.3390/app8020235
Hagiwara M, Maruta N, Marumoto M.
In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells.
Tissue Engineering. Part C, Methods
23(6), 323-332 (2017)
doi: 10.1089/ten.TEC.2017.0126
Hagiwara M.
An in vitro-in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells.
Integrative Biology
8(8), 861-868 (2016)
doi: 10.1039/c6ib00073h
Hagiwara M, Kawahara T, Nobata R.
Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations.
Advanced Healthcare Materials
5(13), 1566-1571 (2016)
doi: 10.1002/adhm.201600167
Members
Masaya Hagiwara
RIKEN Hakubi Team Leader
Raja Kumar Vadivelu
Special Postdoctoral Researcher
Isabel Siew Yin Koh
Postdoctoral Researcher
Yen Xuan Ngo
Postdoctoral Researcher
Satoko Kinoshita
Assistant
