BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.



BDR communicates the appeal and significance of our research to society through the use of various media and activities.



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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.


Team Leader
Masaya Hagiwara Ph.D.

Human Biomimetic System RIKEN Hakubi Research Team

LocationKobe / Integrated Innovation Bldg.

E-mailmasaya.hagiwara [at] riken.jp

Please replace [at] with @.

The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets.The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.

Selected Publications

Koh I, Hagiwara M.
Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation.
Communications Biology 6(1), 299 (2023) doi: 10.1038/s42003-023-04694-5

Suthiwanich K, Hagiwara M.
Localization of Multiple Hydrogels with MultiCUBE Platform Spatially Guides 3D Tissue Morphogenesis In Vitro
Advanced Materials Technologies 8(4), 2201660 (2023) doi: 10.1002/admt.202201660

Takano A, Koh I, Hagiwara M.
3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device.
Micromachines 13(2), 156 (2022) doi: 10.3390/mi13020156

Hagiwara M, Maruyama H, Akiyama M, et al.
Weakening of resistance force by cell-ECM interactions regulate cell migration directionality and pattern formation.
Communications Biology 4(1), 808 (2021) doi: 10.1038/s42003-021-02350-4

Hagiwara M, Koh I.
Engineering approaches to control and design the in vitro environment towards the reconstruction of organs.
Development, Growth & Differentiation 62(3), 158-166 (2020) doi: 10.1111/dgd.12647

Hagiwara M, Nobata R, Kawahara T.
Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations.
Journal of Visualized Experiments (2019) doi: 10.3791/59214

Hagiwara M, Nakase I.
Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells.
Biochemical and Biophysical Research Communications 507(1-4), 297-303 (2018) doi: 10.1016/j.bbrc.2018.11.028

Hagiwara M, Nobata R, Kawahara T.
High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations.
Integrative Biology 10(5), 306-312 (2018) doi: 10.1039/c8ib00032h

Hagiwara M, Nobata R, Kawahara T.
Large Scale Imaging by Fine Spatial Alignment of Multi-Scanning Data with Gel Cube Device
Applied Sciences 8(2), 235 (2018) doi: 10.3390/app8020235

Hagiwara M, Maruta N, Marumoto M.
In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells.
Tissue Engineering. Part C, Methods 23(6), 323-332 (2017) doi: 10.1089/ten.TEC.2017.0126

Hagiwara M.
An in vitro-in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells.
Integrative Biology 8(8), 861-868 (2016) doi: 10.1039/c6ib00073h

Hagiwara M, Kawahara T, Nobata R.
Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations.
Advanced Healthcare Materials 5(13), 1566-1571 (2016) doi: 10.1002/adhm.201600167



Masaya Hagiwara

RIKEN Hakubi Team Leader

Raja Kumar Vadivelu

Special Postdoctoral Researcher

Isabel Siew Yin Koh

Postdoctoral Researcher

Yen Xuan Ngo

Postdoctoral Researcher

Satoko Kinoshita