Our healthspan is influenced by the dietary environment. Diet contributes to metabolic and physiological homeostasis by altering nutritional balance and gut microbiota, yet the molecular mechanisms are not fully understood. Our laboratory studies the functions of each nutrient and gut bacterial species that are dynamically altered in response to various dietary conditions. We also aim to elucidate the mechanisms by which early-life diet impacts lifelong health. Our goal is to reveal evolutionarily conserved "dietological" mechanisms that govern organismal homeostasis and healthspan.
- Physiological functions of nutrients and gut microbiota
- Regulatory mechanism of healthspan by early-life environment
- Regulation of healthspan by dietary amino acids and their metabolism
- Molecular mechanisms of thermotolerance