Team Leader
Fumiaki Obata
Ph.D.
Laboratory for Nutritional Biology
LocationKobe / Developmental Biology Buildings
E-mailfumiaki.obata[at]riken.jp
Please replace [at] with @.
Our healthspan is influenced by the dietary environment. Diet contributes to metabolic and physiological homeostasis by altering nutritional balance and gut microbiota, yet the molecular mechanisms are not fully understood. Our laboratory studies the functions of each nutrient and gut bacterial species that are dynamically altered in response to various dietary conditions. We also aim to elucidate the mechanisms by which early-life diet impacts lifelong health. Our goal is to reveal evolutionarily conserved "dietological" mechanisms that govern organismal homeostasis and healthspan.
Research Theme
- Physiological functions of nutrients and gut microbiota
- Regulatory mechanism of healthspan by early-life environment
- Regulation of healthspan by dietary amino acids and their metabolism
- Molecular mechanisms of thermotolerance
Selected Publications
Onuma T, Yamauchi T, Kosakamoto H, et al.
Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.
PLOS Genetics
19(4), e1010709 (2023)
doi: 10.1371/journal.pgen.1010709
Kosakamoto H, Okamoto N, Aikawa H, et al.
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.
Nature Metabolism
4(7), 944-959 (2022)
doi: 10.1038/s42255-022-00608-7
Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience
23, 101477 (2020)
doi: 10.1016/j.isci.2020.101477
Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports
32(3), 107938 (2020)
doi: 10.1016/j.celrep.2020.107938
Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell
44(6), 741-751 (2018)
doi: 10.1016/j.devcel.2018.02.017
Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications
9(1), 975 (2018)
doi: 10.1038/s41467-018-03070-w
