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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

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Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

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Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

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BDR communicates the appeal and significance of our research to society through the use of various media and activities.

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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Fumiaki Obata

Team Leader
Fumiaki Obata Ph.D.

Laboratory for Nutritional Biology

LocationKobe / Developmental Biology Buildings

E-mailfumiaki.obata[at]riken.jp

Please replace [at] with @.

Unveiling the "logic" behind the dietary regulation of healthspan

Our healthspan is influenced by the dietary environment. Diet contributes to metabolic and physiological homeostasis by altering nutritional balance and gut microbiota, yet the molecular mechanisms are not fully understood. Our laboratory studies the functions of each nutrient and gut bacterial species that are dynamically altered in response to various dietary conditions. We also aim to elucidate the mechanisms by which early-life diet impacts lifelong health. Our goal is to reveal evolutionarily conserved "dietological" mechanisms that govern organismal homeostasis and healthspan.

Research Theme

  • Physiological functions of nutrients and gut microbiota
  • Regulatory mechanism of healthspan by early-life environment
  • Regulation of healthspan by dietary amino acids and their metabolism
  • Molecular mechanisms of thermotolerance

Selected Publications

Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience 23, 101477 (2020) doi: 10.1016/j.isci.2020.101477

Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports 32(3), 107938 (2020) doi: 10.1016/j.celrep.2020.107938

Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell 44(6), 741-751 (2018) doi: 10.1016/j.devcel.2018.02.017

Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications 9(1), 975 (2018) doi: 10.1038/s41467-018-03070-w

Obata F, Miura M.
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
Nature Communications 6, 8332 (2015) doi: 10.1038/ncomms9332

Obata F, Tanaka S, Kashio S, et al.
Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.
BMC Biology 13, 48 (2015) doi: 10.1186/s12915-015-0160-2

Obata F, Kuranaga E, Tomioka K, et al.
Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
Cell Reports 7(3), 821-833 (2014) doi: 10.1016/j.celrep.2014.03.046

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