Wataru Kimura | Laboratory for Heart Regeneration

Nishiyama C, Saito Y, Sakaguchi A, et al.
Prolonged Myocardial Regenerative Capacity in Neonatal Opossum.
Circulation 146(2), 125-139 Thu May 26 00:00:00 JST 2022 doi: 10.1161/CIRCULATIONAHA.121.055269

Sakaguchi A, Kimura W.
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics.
Current Opinion in Genetics and Development 70, 54-60 Fri Oct 08 00:00:00 JST 2021 doi: 10.1016/j.gde.2021.05.009

Sakaguchi A, Kimura W.
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics
Current Opinion in Genetics & Development 70, 54-60 Fri Oct 01 00:00:00 JST 2021 doi: 10.1016/j.gde.2021.05.009

Iwasa N, Matsui TK, Iguchi N.
Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation.
Frontiers in Cellular Neuroscience 15, 605030 Fri Oct 01 00:00:00 JST 2021 doi: 10.3389/fncel.2021.605030

Saito Y, Kimura W.
Roles of phase separation for cellular redox maintenance
Frontiers in Genetics 12, 691946 Fri Jul 09 00:00:00 JST 2021 doi: 10.3389/fgene.2021.691946

Sakaguchi A, Nishiyama C, Kimura W.
Cardiac Regeneration as an Environmental Adaptatio
Biochimica et Biophysica Acta - Molecular Cell Research 1867(4), 118623 Wed Apr 01 00:00:00 JST 2020 doi: 10.1016/j.bbamcr.2019.118623

Sakaguchi A, Nishiyama C, Kimura W.
Cardiac regeneration as an environmental adaptation.
Biochimica et Biophysica Acta. Molecular Cell Research 1867(4), 118623 Wed Apr 01 00:00:00 JST 2020 doi: 10.1016/j.bbamcr.2019.118623

Kimura W, Nakada Y, Sadek HA.
Hypoxia-induced myocardial regeneration.
Journal of Applied Physiology 123(6), 1676-1681 Fri Dec 01 00:00:00 JST 2017 doi: 10.1152/japplphysiol.00328.2017

Nakada Y, Canseco D C, Thet S, et al.
Hypoxia induces heart regeneration in adult mice.
Nature 541, 222-227 Fri Dec 01 00:00:00 JST 2017 doi: 10.1038/nature20173

Mani RS, Amin MA, Li X, et al.
Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.
Cell Reports 17(10), 2620-2631 Tue Dec 06 00:00:00 JST 2016 doi: 10.1016/j.celrep.2016.11.019

Koizumi A, Sasano T, Kimura W, et al.
Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias.
European Heart Journal 37(18), 1469-75 Sat May 07 00:00:00 JST 2016 doi: 10.1093/eurheartj/ehv449

Kimura W, Muralidhar S, Thet S.
Minor contribution of cardiac progenitor cells in neonatal heart regeneration.
Etiology and Morphogenesis of Congenital Heart Disease (Springer), Thu Dec 31 00:00:00 JST 2015

Kocabas F, Xie L, Xie J, et al.
Hypoxic metabolism in human hematopoietic stem cells.
Cell & Bioscience 5, 39 Tue Dec 01 00:00:00 JST 2015 doi: 10.1186/s13578-015-0020-3

Uddin MK, Kimura W, Ishikura T, et al.
Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation.
Biomedical Research 36(4), 235-45 Tue Dec 01 00:00:00 JST 2015 doi: 10.2220/biomedres.36.235

Kimura W, Xiao F, Canseco D C, et al.
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Nature 523, 226-230 Tue Dec 01 00:00:00 JST 2015 doi: 10.1038/nature14582

Canseco D C, Kimura W, Garg S, et al.
Human ventricular unloading induces cardiomyocyte proliferation.
Journal of the American College of Cardiology 65, 892-900 Sun Nov 01 00:00:00 JST 2015 doi: 10.1016/j.jacc.2014.12.027

Sabine A, Bovay E, Demir CS, et al.
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.
The Journal of Clinical investigation 125(10), 3861-77 Thu Oct 01 00:00:00 JST 2015 doi: 10.1172/JCI80454

Nakada Y, Kimura W, Sadek HA.
Defining the Limit of Embryonic Heart Regeneration.
Circulation 132(2), 77-8 Tue Jul 14 00:00:00 JST 2015 doi: 10.1161/CIRCULATIONAHA.115.017070

Xiao F, Kimura W, Sadek HA.
A hippo "AKT" regulates cardiomyocyte proliferation.
Circulation Research 116(1), 3-5 Fri Jan 02 00:00:00 JST 2015 doi: 10.1161/CIRCRESAHA.114.305325

Puente B N, Kimura W, Muralidhar S A, et al.
The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response.
Cell 157, 565-579 Mon Dec 01 00:00:00 JST 2014 doi: 10.1016/j.cell.2014.03.032

Kimura W, Muralidhar S, Canseco DC, et al.
Redox signaling in cardiac renewal.
Antioxidants & Redox Signaling 21(11), 1660-73 Fri Oct 10 00:00:00 JST 2014 doi: 10.1089/ars.2014.6029

Mahmoud AI, Porrello ER, Kimura W, et al.
Surgical models for cardiac regeneration in neonatal mice.
Nature Protocols 9(2), 305-11 Sat Feb 01 00:00:00 JST 2014 doi: 10.1038/nprot.2014.021

Wu YX, Sato E, Kimura W, Miura N.
Baicalin and scutellarin are proteasome inhibitors that specifically target chymotrypsin-like catalytic activity.
Phytotherapy Research 27(9), 1362-7 Sun Sep 01 00:00:00 JST 2013 doi: 10.1002/ptr.4878

Kimura W, Sharkar MT, Sultana N, et al.
Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium.
Transgenic Research 22(3), 659-66 Sat Jun 01 00:00:00 JST 2013 doi: 10.1007/s11248-012-9664-5

Mahmoud AI, Kocabas F, Muralidhar SA, et al.
Meis1 regulates postnatal cardiomyocyte cell cycle arrest.
Nature 497(7448), 249-253 Thu May 09 00:00:00 JST 2013 doi: 10.1038/nature12054

Kimura W, Sadek HA.
The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors.
Cardiovascular Diagnosis and Therapy 2(4), 278-89 Sat Dec 01 00:00:00 JST 2012 doi: 10.3978/j.issn.2223-3652.2012.12.02

Okano J, Kimura W, Papaionnou VE, et al.
The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves.
Developmental Dynamics 241(11), 1744-56 Thu Nov 01 00:00:00 JST 2012 doi: 10.1002/dvdy.23862

Wang B, Hikosaka K, Sultana N, et al.
Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes.
Biochemical and Biophysical Research Communications 417(1), 601-6 Fri Jan 06 00:00:00 JST 2012 doi: 10.1016/j.bbrc.2011.12.014

Kimura W, Alev C, Sheng G, et al.
Identification of region-specific genes in the early chicken endoderm.
Gene Expression Patterns 11(3-4), 171-80 Thu Dec 01 00:00:00 JST 2011 doi: 10.1016/j.gep.2010.11.002

Hikosaka K, Noritake H, Kimura W, et al.
Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry.
Biomedical Research 32(2), 143-50 Fri Apr 01 00:00:00 JST 2011

Kimura W, Machii M, Xue X, et al.
Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development.
Genesis 49(1), 2-9 Sat Jan 01 00:00:00 JST 2011 doi: 10.1002/dvg.20688

Yang Z, Hikosaka K, Sharkar MT, et al.
The mouse forkhead gene Foxp2 modulates expression of the lung genes.
Life Sciences 87(1-2), 17-25 Sat Jul 03 00:00:00 JST 2010 doi: 10.1016/j.lfs.2010.05.009

Xue XD, Kimura W, Wang B, et al.
A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10^lacZ allele.
Genesis 48(5), 295-302 Sat May 01 00:00:00 JST 2010 doi: 10.1002/dvg.20615

Katsumoto K, Fukuda K, Kimura W, et al.
Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization.
Mechanisms of Development 126(7), 539-51 Wed Jul 01 00:00:00 JST 2009 doi: 10.1016/j.mod.2009.03.006

Itakura T, Chandra A, Yang Z, et al.
The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function.
Journal of Biochemistry 143(3), 407-16 Sat Mar 01 00:00:00 JST 2008 doi: 10.1093/jb/mvm235

Kimura W, Yasugi S, Fukuda K.
Regional specification of the endoderm in the early chick embryo.
Development, Growth & Differentiation 49(5), 365-72 Fri Jun 01 00:00:00 JST 2007 doi: 10.1111/j.1440-169X.2007.00933.x

Kimura W, Yasugi S, Stern CD, Fukuda K.
Fate and plasticity of the endoderm in the early chick embryo.
Developmental Biology 289(2), 283-95 Sun Jan 15 00:00:00 JST 2006 doi: 10.1016/j.ydbio.2005.09.009

Hojo M, Takada I, Kimura W, et al.
Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs.
Gene Expression Patterns 6(2), 171-9 Sun Jan 01 00:00:00 JST 2006 doi: 10.1016/j.modgep.2005.06.009