Wataru Kimura | Laboratory for Heart Regeneration

Xiao F, Nguyen N, Wang P, et al.
Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis
Circulation 150(10), (2024) doi: 10.1161/CIRCULATIONAHA.122.059102

Saito Y, Sugiura Y, Sakaguchi A, et al.
Postnatal xanthine metabolism regulates cardiac regeneration in mammals
bioRxiv (2024) doi: 10.1101/2024.07.24.605040

Nishiyama C, Saito Y, Sakaguchi A, et al.
Prolonged Myocardial Regenerative Capacity in Neonatal Opossum.
Circulation 146(2), 125-139 (2022) doi: 10.1161/CIRCULATIONAHA.121.055269

Sakaguchi A, Kawasaki M, Saito Y, et al.
Benzyl isothiocyanate induces cardiomyocyte proliferation and heart regeneration
bioRxiv 146, (2022) doi: 10.1101/2021.09.08.459197

Sakaguchi A, Kimura W.
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics.
Current Opinion in Genetics and Development 70, 54-60 (2021) doi: 10.1016/j.gde.2021.05.009

Sakaguchi A, Kimura W.
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics
Current Opinion in Genetics & Development 70, 54-60 (2021) doi: 10.1016/j.gde.2021.05.009

Iwasa N, Matsui TK, Iguchi N.
Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation.
Frontiers in Cellular Neuroscience 15, 605030 (2021) doi: 10.3389/fncel.2021.605030

Saito Y, Kimura W.
Roles of phase separation for cellular redox maintenance
Frontiers in Genetics 12, 691946 (2021) doi: 10.3389/fgene.2021.691946

Sakaguchi A, Nishiyama C, Kimura W.
Cardiac Regeneration as an Environmental Adaptatio
Biochimica et Biophysica Acta - Molecular Cell Research 1867(4), 118623 (2020) doi: 10.1016/j.bbamcr.2019.118623

Sakaguchi A, Nishiyama C, Kimura W.
Cardiac regeneration as an environmental adaptation.
Biochimica et Biophysica Acta. Molecular Cell Research 1867(4), 118623 (2020) doi: 10.1016/j.bbamcr.2019.118623

Kimura W, Nakada Y, Sadek HA.
Hypoxia-induced myocardial regeneration.
Journal of Applied Physiology 123(6), 1676-1681 (2017) doi: 10.1152/japplphysiol.00328.2017

Nakada Y, Canseco D C, Thet S, et al.
Hypoxia induces heart regeneration in adult mice.
Nature 541, 222-227 (2017) doi: 10.1038/nature20173

Mani RS, Amin MA, Li X, et al.
Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.
Cell Reports 17(10), 2620-2631 (2016) doi: 10.1016/j.celrep.2016.11.019

Koizumi A, Sasano T, Kimura W, et al.
Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias.
European Heart Journal 37(18), 1469-75 (2016) doi: 10.1093/eurheartj/ehv449

Kimura W, Muralidhar S, Thet S.
Minor contribution of cardiac progenitor cells in neonatal heart regeneration.
Etiology and Morphogenesis of Congenital Heart Disease (Springer), (2015)

Kocabas F, Xie L, Xie J, et al.
Hypoxic metabolism in human hematopoietic stem cells.
Cell & Bioscience 5, 39 (2015) doi: 10.1186/s13578-015-0020-3

Uddin MK, Kimura W, Ishikura T, et al.
Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation.
Biomedical Research 36(4), 235-45 (2015) doi: 10.2220/biomedres.36.235

Kimura W, Xiao F, Canseco D C, et al.
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Nature 523, 226-230 (2015) doi: 10.1038/nature14582

Canseco D C, Kimura W, Garg S, et al.
Human ventricular unloading induces cardiomyocyte proliferation.
Journal of the American College of Cardiology 65, 892-900 (2015) doi: 10.1016/j.jacc.2014.12.027

Sabine A, Bovay E, Demir CS, et al.
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.
The Journal of Clinical investigation 125(10), 3861-77 (2015) doi: 10.1172/JCI80454

Nakada Y, Kimura W, Sadek HA.
Defining the Limit of Embryonic Heart Regeneration.
Circulation 132(2), 77-8 (2015) doi: 10.1161/CIRCULATIONAHA.115.017070

Xiao F, Kimura W, Sadek HA.
A hippo "AKT" regulates cardiomyocyte proliferation.
Circulation Research 116(1), 3-5 (2015) doi: 10.1161/CIRCRESAHA.114.305325

Puente B N, Kimura W, Muralidhar S A, et al.
The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response.
Cell 157, 565-579 (2014) doi: 10.1016/j.cell.2014.03.032

Kimura W, Muralidhar S, Canseco DC, et al.
Redox signaling in cardiac renewal.
Antioxidants & Redox Signaling 21(11), 1660-73 (2014) doi: 10.1089/ars.2014.6029

Mahmoud AI, Porrello ER, Kimura W, et al.
Surgical models for cardiac regeneration in neonatal mice.
Nature Protocols 9(2), 305-11 (2014) doi: 10.1038/nprot.2014.021

Wu YX, Sato E, Kimura W, Miura N.
Baicalin and scutellarin are proteasome inhibitors that specifically target chymotrypsin-like catalytic activity.
Phytotherapy Research 27(9), 1362-7 (2013) doi: 10.1002/ptr.4878

Kimura W, Sharkar MT, Sultana N, et al.
Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium.
Transgenic Research 22(3), 659-66 (2013) doi: 10.1007/s11248-012-9664-5

Mahmoud AI, Kocabas F, Muralidhar SA, et al.
Meis1 regulates postnatal cardiomyocyte cell cycle arrest.
Nature 497(7448), 249-253 (2013) doi: 10.1038/nature12054

Kimura W, Sadek HA.
The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors.
Cardiovascular Diagnosis and Therapy 2(4), 278-89 (2012) doi: 10.3978/j.issn.2223-3652.2012.12.02

Okano J, Kimura W, Papaionnou VE, et al.
The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves.
Developmental Dynamics 241(11), 1744-56 (2012) doi: 10.1002/dvdy.23862

Wang B, Hikosaka K, Sultana N, et al.
Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes.
Biochemical and Biophysical Research Communications 417(1), 601-6 (2012) doi: 10.1016/j.bbrc.2011.12.014

Kimura W, Alev C, Sheng G, et al.
Identification of region-specific genes in the early chicken endoderm.
Gene Expression Patterns 11(3-4), 171-80 (2011) doi: 10.1016/j.gep.2010.11.002

Hikosaka K, Noritake H, Kimura W, et al.
Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry.
Biomedical Research 32(2), 143-50 (2011)

Kimura W, Machii M, Xue X, et al.
Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development.
Genesis 49(1), 2-9 (2011) doi: 10.1002/dvg.20688

Yang Z, Hikosaka K, Sharkar MT, et al.
The mouse forkhead gene Foxp2 modulates expression of the lung genes.
Life Sciences 87(1-2), 17-25 (2010) doi: 10.1016/j.lfs.2010.05.009

Xue XD, Kimura W, Wang B, et al.
A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10^lacZ allele.
Genesis 48(5), 295-302 (2010) doi: 10.1002/dvg.20615

Katsumoto K, Fukuda K, Kimura W, et al.
Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization.
Mechanisms of Development 126(7), 539-51 (2009) doi: 10.1016/j.mod.2009.03.006

Itakura T, Chandra A, Yang Z, et al.
The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function.
Journal of Biochemistry 143(3), 407-16 (2008) doi: 10.1093/jb/mvm235

Kimura W, Yasugi S, Fukuda K.
Regional specification of the endoderm in the early chick embryo.
Development, Growth & Differentiation 49(5), 365-72 (2007) doi: 10.1111/j.1440-169X.2007.00933.x

Kimura W, Yasugi S, Stern CD, Fukuda K.
Fate and plasticity of the endoderm in the early chick embryo.
Developmental Biology 289(2), 283-95 (2006) doi: 10.1016/j.ydbio.2005.09.009

Hojo M, Takada I, Kimura W, et al.
Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs.
Gene Expression Patterns 6(2), 171-9 (2006) doi: 10.1016/j.modgep.2005.06.009