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Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Hiroshi Hamada

Team Leader
Hiroshi Hamada M.D., Ph.D.

Laboratory for Organismal Patterning

Location Kobe / Developmental Biology Buildings

E-mailhiroshi.hamada[at]riken.jp

Please replace [at] with @.

My lab studies how left-right asymmetries develop in the mouse embryo. In particular, we focus on two types of cilia that are required for left-right symmetry breaking: rotating cilia that generate leftward fluid flow, and immotile cilia that sense the fluid flow. We also study the role of maternal epigenetic regulators in development. We address these questions by integrating live imaging, structural biology, fluid dynamics and mathematical modeling.

How left-right asymmetry is established in vertebrates

Role of motile and immotile cilia in left-right symmetry breaking

Maternal and paternal epigenome in development



Research Theme

  • How motion pattern of node cilia is determined
  • How immotile cilia sense fluid flow
  • Role of maternal and paternal epigenetic factors in development

Selected Publications

Mizuno K, Shiozawa K, Katoh TA, et al.
Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry.
Science Advances 6, eaba1195 (2020) doi: 10.1126/sciadv.aba1195

Kajikawa E, Horo U, Ide T, et al.
Nodal paralogues underlie distinct mechanisms for visceral left-right asymmetry in reptiles and mammals.
Nature Ecology & Evolution 4, 261-269 (2020) doi: 10.1038/s41559-019-1072-2

Nabeshima R, Nishimura O, Maeda T, et al.
Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters.
eLife 7, e36435 (2018) doi: 10.7554/eLife.36435

Takaoka K, Nishimura H, Hamada H.
Both Nodal signaling and stochasticity select for prospective distal visceral endoderm in mouse embryos.
Nature Communications 8, 1492 (2017) doi: 10.1038/s41467-017-01625-x

Minegishi K, Hashimoto M, Ajima R, et al.
A Wnt5 activity asymmetry and intercellular signaling polarize node cells for breaking left-right symmetry in the mouse embryo.
Developmental Cell 40, 439-452 (2017) doi: 10.1016/j.devcel.2017.02.010

Shinohara K, Chen D, Nishida T, et al.
Absence of radial spokes in mouse node cilia is required for rotational movement but confers ultrastructural instability as a trade-off.
Developmental Cell 35, 236-246 (2015) doi: 10.1016/j.devcel.2015.10.001

Nakamura T, Saito D, Kawasumi A, et al.
Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA in the mouse embryo.
Nature Communications 3, 1322 (2012) doi: 10.1038/ncomms2319

Yoshiba S, Shiratori H, Kuo IY, et al.
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
Science (New York, N.Y.) 338(6104), 226-31 (2012) doi: 10.1126/science.1222538

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