個体はたくさんの種類の細胞から構成される多細胞システムです。1つの細胞が分裂を繰り返して個体ができあがる過程を理解するためには、遺伝子や分子から細胞へ、細胞から組織へ、組織から組織の集合へと、階層を一歩ずつ上がっていく必要があります。そのためには、最新の技術による生命現象の定量的な計測と、物理学や数学を基礎にした計算モデルやコンピュータシミュレーションが不可欠です。私たちの研究室では理論的アプローチと実験データ解析のアプローチを組み合わせて、細胞の情報処理、細胞の運動、細胞集団の協調的運動、遺伝子ネットワークの研究を進めています。
研究テーマ
- 細胞の走化性情報処理のダイナミクス
- 極性形成のダイナミクス
- 転写調節ネットワークのダイナミクス
主要論文
Tarama M, Shibata T.
Pattern formation and the mechanics of a motor-driven filamentous system confined by rigid membranes.
Physical Review Research
4, 043071 Mon Oct 31 00:00:00 JST 2022
doi: 10.1103/PhysRevResearch.4.043071
Wen FL, Kwan CW, Wang YC, Shibata T.
Autonomous epithelial folding induced by an intracellular mechano–polarity feedback loop.
PLOS Computational Biology
17(12), e1009614 Mon Dec 06 00:00:00 JST 2021
doi: 10.1371/journal.pcbi.1009614
Hayakawa M, Hiraiwa T, Wada Y, et al.
Polar pattern formation induced by contact following locomotion in a multicellular system.
eLife
9, e53609 Tue Dec 01 00:00:00 JST 2020
doi: 10.7554/eLife.53609
Kono K, Yoshiura S, Fujita I, et al.
Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization.
eLife
8, e45559 Sun Dec 01 00:00:00 JST 2019
doi: 10.7554/eLife.45559.001
Sekine R, Shibata T, Ebisuya M.
Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty.
Nature communications
9(1), 5456 Sat Dec 01 00:00:00 JST 2018
doi: 10.1038/s41467-018-07847-x
Ogura Y, Wen FL, Sami MM, et al.
A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination.
Developmental cell
46(2), 162-172 Mon Jul 16 00:00:00 JST 2018
doi: 10.1016/j.devcel.2018.06.004
Wen FL, Wang YC, Shibata T.
Epithelial Folding Driven by Apical or Basal-Lateral Modulation: Geometric Features, Mechanical Inference, and Boundary Effects.
Biophysical journal
112(12), 2683-2695 Tue Jun 20 00:00:00 JST 2017
doi: 10.1016/j.bpj.2017.05.012
Sato K, Hiraiwa T, Maekawa E, et al.
Left–right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis.
Nature Communications
6, 10074 Tue Dec 01 00:00:00 JST 2015
doi: 10.1038/ncomms10074
Sato K, Hiraiwa T, Shibata T.
Cell Chirality Induces Collective Cell Migration in Epithelial Sheets.
Physical Review Letters
115(18), 188102 Sun Nov 01 00:00:00 JST 2015
doi: 10.1103/PhysRevLett.115.188102
Hiraiwa T, Nagamatsu A, Akuzawa N, et al.
Relevance of intracellular polarity to accuracy of eukaryotic chemotaxis.
Physical Biology
11(5), 056002 Mon Dec 01 00:00:00 JST 2014
doi: 10.1088/1478-3975/11/5/056002
Nishikawa M, Horning M, Ueda M, Shibata T.
Excitable Signal Transduction Induces Both Spontaneous and Directional Cell Asymmetries in the Phosphatidylinositol Lipid Signaling System for Eukaryotic Chemotaxis.
Biophysical Journal
106(3), 723-734 Sat Nov 01 00:00:00 JST 2014
doi: 10.1016/j.bpj.2013.12.023
Shibata T, Nishikawa M, Matsuoka S, Ueda M.
Intracellular Encoding of Spatiotemporal Guidance Cues in a Self-Organizing Signaling System for Chemotaxis in Dictyostelium Cells.
Biophysical Journal
105(9), 2199-2209 Sun Dec 01 00:00:00 JST 2013
doi: 10.1016/j.bpj.2013.09.024
Inomata H, Shibata T, Haraguchi T, Sasai Y.
Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Spemann's Organizer Signals.
Cell
153(6), 1296-1311 Fri Nov 01 00:00:00 JST 2013
doi: 10.1016/j.cell.2013.05.004
Hiraiwa T, Baba A, Shibata T.
Theoretical model for cell migration with gradient sensing and shape deformation.
European Physical Journal E
36(4), 32 9 Tue Oct 01 00:00:00 JST 2013
doi: 10.1140/epje/i2013-13032-1
Baba A, Hiraiwa T, Shibata T.
Directional sensing of deformed cells under faint gradients.
Physical Review E
86(6), 060901 5 Sat Dec 01 00:00:00 JST 2012
doi: 10.1103/PhysRevE.86.060901
Shibata T, Nishikawa M, Matsuoka S, Ueda M.
Modeling the self-organized phosphatidylinositol lipid signaling system in chemotactic cells using quantitative image analysis.
Journal of Cell Science
125(21), 5138-5150 Thu Nov 01 00:00:00 JST 2012
doi: 10.1242/jcs.108373
