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Category セミナー
Date and Time 2018年04月27日 12:00 - 13:00
Place大阪
VenueOsaka Lounge A1F
SpeakerAtsuko Kasahara
AffiliationKanazawa University
Posterclick here to download(PDF)
TitleMitochondrial dynamics in malignant progression: retrograde control from mitochondria
SummaryMitochondrial pleiotropic functions, such as aerobic respiration to produce huge energy, controlling apoptosis, and calcium regulation are reflected by their extremely dynamic morphology and distribution. Continuous fusion and fission excellently tune mitochondrial quality, distribution, size, and motility. Mitochondria-shaping proteins, dynamin-like GTPase optic atrophy 1 (Opa1), and mitofusin (Mfn) 1, 2 fuse, while cytosolic dynamin- related protein 1 (Drp1) divides mitochondria. Mitochondria have been considered and paid attention as key players in "cancer metabolism", however, growing evidences convince us that their shape and distribution could directly influence the malignant phenotypes of tumour cells.
Mitochondrial dynamics dictates "healthy" cell differentiation via modulating the canonical Notch1 signalling during cardiac differentiation (Kasahara et al., Science 2013). Likewise, mitochondrial dynamics could also control "unhealthy" tumour cell plasticity by impacting on other organelle's functions, such as endoplasmic reticulum (ER) via ER-mitochondria contact sites, or modulating signalling cascades that could possibly change tumour gene expressions. I would like to discuss about our recent study (Bassoy and Kasahara et al., EMBO J. 2017), as well as on-going projects.
HostOkada Yasushi

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