チームリーダー
向井英史 Ph.D.

分子送達・イメージング技術研究チーム

[2023年3月終了]

E-mail hmukai[at]riken.jp

[at]を@に変えてください

概要
主要論文
メンバー
ニュース

分子のより良き動態を探り、標的臓器・細胞へ届ける

健康・疾患状態の統合的な理解とその医療への応用のため、合成生物学・応用微生物学・マテリアルサイエンス・生物工学などの先進的な手法・素材を導入し、非・低侵襲的なドラッグデリバリーシステムやイメージングプローブの開発を行います。

研究テーマ

がん治療用バクテリアマシンの開発
生体高分子PETプローブ：ADME研究とイメージングバイオマーカー開発
無機ナノ粒子・生体由来微粒子を活用したDDSの開発

主要論文

Mukai H, Watanabe Y.
Review: PET imaging with macro- and middle-sized molecular probes.
Nuclear medicine and biology 92, 156-170 (2021) doi: 10.1016/j.nucmedbio.2020.06.007

Nomura S, Takahashi M, Hashiba Kato A, et al.
Biosorption-based ⁶⁴Cu-labeling of bacteria for pharmacokinetic positron-emission tomography.
International Journal of Pharmaceutics 590, 119950 (2020) doi: 10.1016/j.ijpharm.2020.119950

Sakai K, Passioura T, Sato H, et al.
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.
Nature Chemical Biology 15, 598-606 (2019) doi: 10.1038/s41589-019-0285-7

Ren Q, Mohri K, Warashina S, et al.
Improved immuno-PET imaging of HER2-positive tumors in mice: Urokinase injection-triggered clearance enhancement of ⁶⁴Cu-trastuzumab.
Molecular Pharmaceutics 16(3), 1065-1073 (2019) doi: 10.1021/acs.molpharmaceut.8b01052

Mukai H, Hatanaka K, Yagi N, et al.
Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis.
Journal of Controlled Release 294, 185-194 (2019) doi: 10.1016/j.jconrel.2018.12.006

Nakamoto Y, Pradipta AR, Mukai H, et al.
Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium‐68 positron emission tomography.
Chembiochem 19, 2055-2060 (2018) doi: 10.1002/cbic.201800335

Matsumura K, Zouda M, Wada Y, et al.
Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated ⁶⁴Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast.
International Journal of Pharmaceutics 545, 206-214 (2018) doi: 10.1016/j.ijpharm.2018.05.014

Mukai H, Takahashi M, Watanabe Y.
Potential usefulness of Brevibacillus for bacterial cancer therapy: intratumoral provision of tumor necrosis factor- α and anticancer effects.
Cancer Gene Therapy 25, 47-57 (2018) doi: 10.1038/s41417-017-0009-7

Otani Y, Kawakami S, Mukai H, et al.
Long-term in vivo gene expression in mouse kidney using φ31 integrase and electroporation.
Journal of Drug Targeting 23, 427-435 (2015) doi: 10.3109/1061186X.2014.1002788

Mukai H, Ozaki D, Cui YL, et al.
Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with ¹⁸ F-incorporated oligodeoxynucleotides.
Journal of Controlled Release 180, 92-99 (2014) doi: 10.1016/j.jconrel.2014.02.014

Mukai H, Wada Y, Watanabe Y.
The synthesis of ⁶⁴ Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents.
Annals of Nuclear Medicine 27, 625-639 (2013) doi: 10.1007/s12149-013-0728-2

Mukai H, Kawakami S, Takahashi H, et al.
Key physiological phenomena governing transgene expression based on tissue pressure-mediated transfection in mice.
Biological and Pharmaceutical Bulletin 33, 1627-1632 (2010) doi: 10.1248/bpb.33.1627

Mukai H, Kawakami S, Kamiya Y, et al.
Pressure-mediated transfection of murine spleen and liver.
Human Gene Therapy 20, 1157-1167 (2009) doi: 10.1089/hum.2008.213

Ohyama J, Hitomi Y, Higuchi Y, et al.
One-Phase Synthesis of Small Gold Nanoparticles Coated by a Horizontal Porphyrin Monolayer.
Chemical Communications 47, 6300-6302 (2008) doi: 10.1039/b815100h

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