Dietary control of longevity in Drosophila melanogaster
2020年9月16日 13:00 - 14:00
Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Diet has a profound effect on ageing. Various evolutionally-conserved longevity-associated pathways are identified, yet the molecular mechanism underlying diet-host interactions is not fully understood. Using Drosophila melanogaster as a model, we are studying how diet regulates ageing and lifespan. We demonstrated that organismal lifespan and intestinal healthspan could be extended by restriction of a single nutrient methionine, through a downstream metabolite S-adenosylmethionine. We also found that transient exposure to protein restriction or low-dose oxidants during development extends Drosophila lifespan. Interestingly, oxidants in the juvenile diet persistently remodel the gut microbiota, which augments the host metabolic and immune homeostasis and extends lifespan. Based on these findings, I would like to discuss how dietary manipulations modulate cellular and organismal responses regulating longevity.