ロゴマーク
研究

研究

BDRでは、様々な分野の研究者が協力して、より高い目標に向かって研究を進めています。

セミナー・シンポジウム

セミナー・イベント

BDRでは、ライフサイエンス分野の国際的な研究者を招いて、年1回のシンポジウムや定期的なセミナーを開催しています。

働く・学ぶ

働く・学ぶ

BDRでは、様々なバックグラウンドを持つ人々を受け入れ、オープンで協力的な研究環境の構築に努めています。

つながる・楽しむ

つながる・楽しむ

BDRでは、様々なメディアや活動を通じて、研究の魅力や意義を社会に発信しています。

ニュース

ニュース

最新の研究、イベント、研究者のインタビューなど、理研BDRの最新情報をお届けします。

BDRについて

BDRについて

理研の強みを生かし学際的なアプローチで生命の根源を探求し、社会の課題に応えます。

The many faces of estrogen signaling in the male gonad
2018年8月28日 16:00 - 17:00

カテゴリー

セミナー

場所

神戸

会場

DB Bldg. SeminarRoom A7F

スピーカー

Malgosia Kotula-Balak

所属

Jagiellonian University

概要

For the first time, estrogen production in the male testis was documented in 1934, through the discovery of the intratesticular conversion of androgens into estrogens in equine. For next decades estrogens role in male physiology remained not elucidated and linked rather to their unimportant or inhibitory function. In 1988, pioneering study by Kula et al., in immature rats, clearly demonstrated that estrogen signalization is crucial for initiation of spermatogenesis. Discovery in the middle 90ties of the estrogen receptors (ERs) in male, and data showing functional disturbances of the reproductive system and infertility in transgenic mice lacking ERβ or estrogen synthase (aromatase) together with clinical data from patients (with mutations in ER and aromatase genes) considerably extended the knowledge and strongly established positive/stimulatory role of estrogens in males. However, ERs role for individual cell function and ERs expression pattern in testicular cells (somatic, spermatogenic and spermatozoa) is still controversial in many aspects. Currently, growing evidences are available on estrogenic regulation of differentiation, proliferation as well as apoptosis and tumor transformation of testicular cells. In these cellular processes, estrogen action through ERs contribute only to a small part to the complexity of estrogen signaling. Newest data confirm presence of membrane estrogen receptor (GPER) that binds also xenoestrogens in various testicular cells. In addition, estrogen-related receptors (ERR) appeared to be involved directly and indirectly in estrogen signal transmission. ERRs are structurally and functionally similar to ERs playing a role in diverse metabolic (energy and lipid metabolism), developmental and differentiation processes in many cell types in the organisms. Moreover, last data confirm that tumor development is under ERRs control. These and other related issues on exogenous and endogenous estrogen signaling in various types of testicular cells including mechanisms of their action and cellular effects will be presented herein based on literature data and own one.

ホスト

Sa-Kan Yoo

PAGE
TOP