Team Leader (Apr. 2018—Mar. 2025)
Shigenobu Yonemura Ph.D.
Team Director (Apr. 2025—)
Ryoichiro Kageyama M.D., Ph.D.
Laboratory for Ultrastructural Research
LocationKobe / Developmental Biology Buildings
E-mail shigenobu.yonemura@riken.jp
This research team analyzes detailed morphological information in various researches of the life science field, which is acquired through ultrastructural techniques using transmission and scanning electron microscopy. In collaboration with many laboratories including within RIKEN, we have accumulated a large amount of experiences to improve methods for better morphology.
Research Theme
- Regulation of adherens junction remodellig by forces using alpha-catenin as a mechanotransducer.
- Molecular mechanism of perception of dead cells and signaling of wound closure in cell sheets.
- Role of force generated by myosin II on establishment of epithelial polarity.
Selected Publications
Fukuda K, Shimi T, Shimura C, et al.
Epigenetic plasticity safeguards heterochromatin configuration in mammals.
Nucleic Acids Research
(2023)
doi: 10.1093/nar/gkad387
Onai T, Aramaki T, Takai A, et al.
Cranial cartilages: Players in the evolution of the cranium during evolution of the chordates in general and of the vertebrates in particular.
Evolution & Development
25(3), 197-208 (2023)
doi: 10.1111/ede.12433
Tentaku A, Kurisu S, Sejima K, et al.
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro.
FEBS Journal
289(23), 7466-7485 (2022)
doi: 10.1111/febs.16559
Nishimura R, Kato K, Saida M, et al.
Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids.
Cell Structure and Function
47(2), 55-73 (2022)
doi: 10.1247/csf.22014
Saito H, Matsukawa-Usami F, Fujimori T, et al.
Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating.
Molecular Biology of the Cell
32(20), ar12 (2021)
doi: 10.1091/mbc.E21-06-0303
Yonemura S.
Actin filament association at adherens junctions.
The journal of medical investigation : JMI
64(1.2), 14-19 (2017)
doi: 10.2152/jmi.64.14
Tsujioka M, Yumura S, Inouye K, et al.
Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America
109(32), 12992-12997 (2012)
doi: 10.1073/pnas.1208296109
Yonemura S.
A mechanism of mechanotransduction at the cell-cell interface: emergence of α-catenin as the center of a force-balancing mechanism for morphogenesis in multicellular organisms.
Bioessays
33(10), 732-736 (2011)
doi: 10.1002/bies.201100064
Yonemura S.
Cadherin-actin interactions at adherens junctions.
Current Opinion in Cell Biology
23(5), 525-522 (2011)
doi: 10.1016/j.ceb.2011.07.001
Yonemura S, Wada Y, Watanabe T, et al.
alpha-Catenin as a tension transducer that induces adherens junction development.
Nature Cell Biology
12(6), 533-542 (2010)
doi: 10.1038/ncb2055
Members
Ryoichiro Kageyama
Team Director
Shigeo Hayashi
Deputy Team Director
Kenta Onoue
Technical Staff I
Satoko Okayama
Technical Staff I
