Team Leader
Shigenobu Yonemura
Ph.D.
Laboratory for Ultrastructural Research
LocationKobe / Developmental Biology Buildings
E-mailshigenobu.yonemura[at]riken.jp
Please replace [at] with @.
This research team analyzes detailed morphological information in various researches of the life science field, which is acquired through ultrastructural techniques using transmission and scanning electron microscopy. In collaboration with many laboratories including within RIKEN, we have accumulated a large amount of experiences to improve methods for better morphology.
Research Theme
- Regulation of adherens junction remodellig by forces using alpha-catenin as a mechanotransducer.
- Molecular mechanism of perception of dead cells and signaling of wound closure in cell sheets.
- Role of force generated by myosin II on establishment of epithelial polarity.
Selected Publications
Ando T, Sekine S, Inagaki S, et al.
Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum.
Current biology : CB
29(9), 1512-1520 (2019)
doi: 10.1016/j.cub.2019.03.043
Maki K, Han SW, Hirano Y, et al.
Real-time TIRF observation of vinculin recruitment to stretched α-catenin by AFM.
Scientific Report.
8(1), 1575 (2018)
doi: 10.1038/s41598-018-20115-8
Yonemura S.
Actin filament association at adherens junctions.
The journal of medical investigation : JMI
64(1.2), 14-19 (2017)
doi: 10.2152/jmi.64.14
Akiyama T, Inoko A, Kaji Y, et al.
SHG-specificity of cellular Rootletin filaments enables naïve imaging with universal conservation.
Scientific Report.
7, 39967 (2017)
doi: 10.1038/srep39967
Otani T, Ogura Y, Misaki K, et al.
IKKϵ inhibits PKC to promote Fascin-dependent actin bundling.
Development.
143(20), 3806-3816 (2016)
doi: 10.1242/dev.138495
Maki K, Han SW, Hirano Y, et al.
Mechano-adaptive sensory mechanism of α-catenin under tension.
Scientific Report.
6, 24878 (2016)
doi: 10.1038/srep24878
Shibata N, Kashima M, Ishiko T, et al.
Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
Developmental Cell.
37(3), 226-37 (2016)
doi: 10.1016/j.devcel.2016.04.009
Tsujioka M, Yumura S, Inouye K, et al.
Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America
109(32), 12992-12997 (2012)
doi: 10.1073/pnas.1208296109
Yonemura S.
A mechanism of mechanotransduction at the cell-cell interface: emergence of α-catenin as the center of a force-balancing mechanism for morphogenesis in multicellular organisms.
Bioessays
33(10), 732-736 (2011)
doi: 10.1002/bies.201100064
Yonemura S.
Cadherin-actin interactions at adherens junctions.
Current Opinion in Cell Biology
23(5), 525-522 (2011)
doi: 10.1016/j.ceb.2011.07.001
Yonemura S, Wada Y, Watanabe T, et al.
alpha-Catenin as a tension transducer that induces adherens junction development.
Nature Cell Biology
12(6), 533-542 (2010)
doi: 10.1038/ncb2055
Members
Shigenobu Yonemura
Team Leader
Shigeo Hayashi
Deputy Team Leader
Kenta Onoue
Technical Staff I
Satoko Okayama
Technical Staff I
