Team Leader
Eisuke Nishida
Ph.D.
Laboratory for Molecular Biology of Aging
LocationKobe / Developmental Biology Buildings
E-maileisuke.nishida[at]riken.jp
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The organismal lifespan varies from species to species, and it also varies among individuals of the same species. Despite such large differences in the organismal lifespan or the rate of aging, recent studies suggest the existence of the common mechanisms of lifespan/aging regulation. The best studied common mechanism of lifespan regulation came from the research using a tiny soil worm called C. elegans. Both “nature (genetic factors)” and “nurture (environmental factors)” are shown to influence lifespan/aging. Our laboratory uses C. elegans and small fish to understand the molecular mechanisms underlying lifespan regulation by genetic and environmental factors.
Research Theme
- Inter-organ communications underlying aging regulation
- Epigenomic regulation of aging
- Mechanisms of transgenerational inheritance of epigenetic memories
Selected Publications
Okabe E, Uno M, Kishimoto S, Nishida E.
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans.
Communications biology
4, 207 Wed Dec 01 00:00:00 JST 2021
doi: 10.1038/s42003-021-01692-3
Takahashi TM, Sunagawa GA, Soya S, et al.
A discrete neuronal circuit induces a hibernation-like state in rodents.
Nature
583, 109-114 Tue Dec 01 00:00:00 JST 2020
doi: 10.1038/s41586-020-2163-6
Nono M, Kishimoto S, Sato-Carlton A, et al.
Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans..
Cell Reports
30, 3207-3217 Sun Nov 01 00:00:00 JST 2020
doi: 10.1016/j.celrep.2020.02.050
Ikeda T, Uno M, Honjoh S, Nishida E.
The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors.
EMBO Reports
18(10), 1716-1726 Fri Dec 01 00:00:00 JST 2017
doi: 10.15252/embr.201743907
Kishimoto S, Uno M, Okabe E, et al.
Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans.
Nature Communications
8, 14031. Wed Nov 01 00:00:00 JST 2017
doi: 10.1038/ncomms14031
Miyatake K, Kusakabe M, Takahashi C, Nishida E.
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.
Nature Communications
6, 6666 Tue Dec 01 00:00:00 JST 2015
doi: 10.1038/ncomms7666
Takahashi C, Kusakabe M, Suzuki T, et al.
mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes.
Nature Communications
6, 6017 Sun Nov 01 00:00:00 JST 2015
doi: 10.1038/ncomms7017
Imajo M, Ebisuya M, Nishida E.
Dual role of YAP and TAZ in renewal of the intestinal epithelium.
Nature Cell Biology
17(1), 7-19 Thu Oct 01 00:00:00 JST 2015
doi: 10.1038/ncb3084
Sunadome K, Suzuki T, Usui M, et al.
Antagonism between the Master Regulators of Differentiation Ensures the Discreteness and Robustness of Cell Fates.
Molecular Cell
54(3), 526-535 Mon Dec 01 00:00:00 JST 2014
doi: 10.1016/j.molcel.2014.03.005
Uno M, Honjoh S, Matsuda M, et al.
A fasting-responsive signaling pathway that extends life span in C. elegans.
Cell Reports
3(1), 79-91 Sun Dec 01 00:00:00 JST 2013
doi: 10.1016/j.celrep.2012.12.018
Okuyama T, Inoue H, Ookuma S, et al.
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
Journal of Biological Chemistry
285(39), 30274-30281 Wed Dec 01 00:00:00 JST 2010
doi: 10.1074/jbc.M110.146274
Hanafusa H, Matsumoto K, Nishida E.
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.
Nature Cell Biology
11, 106-109 Tue Dec 01 00:00:00 JST 2009
doi: 10.1038/ncb1820
Honjoh S, Yamamoto T, Uno M, Nishida E.
Signaling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
Nature
457, 726-730 Sun Nov 01 00:00:00 JST 2009
doi: 10.1038/nature07583
Members
Eisuke Nishida
Team Leader
Masaharu Uno
Research Scientist
Chika Takahashi
Research Scientist
Emiko Okabe
Research Scientist
Masanori Nono
Research Scientist
News
Oct. 11, 2023 BDR News
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Dec. 25, 2020 Research
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Aug. 28, 2020 Research
A neural circuit that makes rodents go into a hibernation-like state found