Laboratory for Molecular Biology of Aging | RIKEN BDR

Laboratory for Molecular Biology of Aging

Team Leader

Eisuke NishidaPh.D.

Photo of principal investigator

  • Location:Kobe / Developmental Biology Buildings
  • E-mail:eisuke.nishida[at]riken.jpPlease replace [at] with @.

Understanding of molecular mechanisms regulating organismal aging

Research Summary

The organismal lifespan varies from species to species, and it also varies among individuals of the same species. Despite such large differences in the organismal lifespan or the rate of aging, recent studies suggest the existence of the common mechanisms of lifespan/aging regulation. The best studied common mechanism of lifespan regulation came from the research using a tiny soil worm called C. elegans. Both “nature (genetic factors)” and “nurture (environmental factors)” are shown to influence lifespan/aging. Our laboratory uses C. elegans and small fish to understand the molecular mechanisms underlying lifespan regulation by genetic and environmental factors.

Research Theme

  • Inter-organ communications underlying aging regulation
  • Epigenomic regulation of aging
  • Mechanisms of transgenerational inheritance of epigenetic memories

Main Publications List

  • Uno M, Tani Y, Nono M, et al.
    Neuronal DAF-16-to-Intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans.
    iScience 24, 102706 (2021) doi: 10.1016/j.isci.2021.102706
  • Okabe E, Uno M, Kishimoto S, Nishida E.
    Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans.
    Communications biology 4, 207 (2021) doi: 10.1038/s42003-021-01692-3
  • Takahashi TM, Sunagawa GA, Soya S, et al.
    A discrete neuronal circuit induces a hibernation-like state in rodents.
    Nature 583, 109–114 (2020) doi: 10.1038/s41586-020-2163-6
  • Nono M, Kishimoto S, Sato-Carlton A, et al.
    Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.
    Cell Reports 30, 3207-3217 (2020) doi: 10.1016/j.celrep.2020.02.050
  • Ikeda T, Uno M, Honjoh S, Nishida E.
    The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors.
    EMBO Reports 18(10), 1716-1726 (2017) doi :10.15252/embr.201743907
  • Kishimoto S, Uno M, Okabe E, et al.
    Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans.
    Nature Communications 8, 14031. (2017) doi :10.1038/ncomms14031
  • Miyatake K, Kusakabe M, Takahashi C, Nishida E.
    ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.
    Nature Communications 6, 6666 (2015) doi :10.1038/ncomms7666
  • Takahashi C, Kusakabe M, Suzuki T, et al.
    mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes.
    Nature Communications 6, 6017 (2015) doi :10.1038/ncomms7017
  • Imajo M, Ebisuya M, Nishida E.
    Dual role of YAP and TAZ in renewal of the intestinal epithelium.
    Nature Cell Biology 17(1), 7-19 (2015) doi :10.1038/ncb3084
  • Sunadome K, Suzuki T, Usui M, et al.
    Antagonism between the Master Regulators of Differentiation Ensures the Discreteness and Robustness of Cell Fates.
    Molecular Cell 54(3), 526-535 (2014) doi :10.1016/j.molcel.2014.03.005
  • Uno M, Honjoh S, Matsuda M, et al.
    A fasting-responsive signaling pathway that extends life span in C. elegans.
    Cell Reports 3(1),79-91 (2013) doi :10.1016/j.celrep.2012.12.018
  • Okuyama T, Inoue H, Ookuma S, et al.
    The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
    Journal of Biological Chemistry 285(39), 30274-30281 (2010) doi :10.1074/jbc.M110.146274
  • Hanafusa H, Matsumoto K, Nishida E.
    Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.
    Nature Cell Biology 11, 106-109 (2009) doi :10.1038/ncb1820
  • Honjoh S, Yamamoto T, Uno M, Nishida E.
    Signaling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
    Nature 457, 726-730 (2009) doi :10.1038/nature07583


Eisuke NishidaTeam Leader eisuke.nishida[at]
Masaharu UnoResearch Scientist
Chika TakahashiResearch Scientist
Saya KishimotoResearch Scientist

*:concurrent / Please replace [at] with @.