BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

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Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.



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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Eisuke Nishida

Team Leader
Eisuke Nishida Ph.D.

Laboratory for Molecular Biology of Aging

LocationKobe / Developmental Biology Buildings


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Understanding of molecular mechanisms regulating organismal aging

The organismal lifespan varies from species to species, and it also varies among individuals of the same species. Despite such large differences in the organismal lifespan or the rate of aging, recent studies suggest the existence of the common mechanisms of lifespan/aging regulation. The best studied common mechanism of lifespan regulation came from the research using a tiny soil worm called C. elegans. Both “nature (genetic factors)” and “nurture (environmental factors)” are shown to influence lifespan/aging. Our laboratory uses C. elegans and small fish to understand the molecular mechanisms underlying lifespan regulation by genetic and environmental factors.

Research Theme

  • Inter-organ communications underlying aging regulation
  • Epigenomic regulation of aging
  • Mechanisms of transgenerational inheritance of epigenetic memories

Selected Publications

Okabe E, Uno M, Kishimoto S, Nishida E.
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans.
Communications biology 4, 207 (2021) doi: 10.1038/s42003-021-01692-3

Takahashi TM, Sunagawa GA, Soya S, et al.
A discrete neuronal circuit induces a hibernation-like state in rodents.
Nature 583, 109-114 (2020) doi: 10.1038/s41586-020-2163-6

Nono M, Kishimoto S, Sato-Carlton A, et al.
Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans..
Cell Reports 30, 3207-3217 (2020) doi: 10.1016/j.celrep.2020.02.050

Ikeda T, Uno M, Honjoh S, Nishida E.
The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors.
EMBO Reports 18(10), 1716-1726 (2017) doi: 10.15252/embr.201743907

Kishimoto S, Uno M, Okabe E, et al.
Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans.
Nature Communications 8, 14031. (2017) doi: 10.1038/ncomms14031

Miyatake K, Kusakabe M, Takahashi C, Nishida E.
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled.
Nature Communications 6, 6666 (2015) doi: 10.1038/ncomms7666

Takahashi C, Kusakabe M, Suzuki T, et al.
mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes.
Nature Communications 6, 6017 (2015) doi: 10.1038/ncomms7017

Imajo M, Ebisuya M, Nishida E.
Dual role of YAP and TAZ in renewal of the intestinal epithelium.
Nature Cell Biology 17(1), 7-19 (2015) doi: 10.1038/ncb3084

Sunadome K, Suzuki T, Usui M, et al.
Antagonism between the Master Regulators of Differentiation Ensures the Discreteness and Robustness of Cell Fates.
Molecular Cell 54(3), 526-535 (2014) doi: 10.1016/j.molcel.2014.03.005

Uno M, Honjoh S, Matsuda M, et al.
A fasting-responsive signaling pathway that extends life span in C. elegans.
Cell Reports 3(1), 79-91 (2013) doi: 10.1016/j.celrep.2012.12.018

Okuyama T, Inoue H, Ookuma S, et al.
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
Journal of Biological Chemistry 285(39), 30274-30281 (2010) doi: 10.1074/jbc.M110.146274

Hanafusa H, Matsumoto K, Nishida E.
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.
Nature Cell Biology 11, 106-109 (2009) doi: 10.1038/ncb1820

Honjoh S, Yamamoto T, Uno M, Nishida E.
Signaling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
Nature 457, 726-730 (2009) doi: 10.1038/nature07583


Eisuke Nishida

Team Leader

Masaharu Uno

Research Scientist

Chika Takahashi

Research Scientist

Emiko Okabe

Research Scientist

Masanori Nono

Research Scientist