BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.



BDR communicates the appeal and significance of our research to society through the use of various media and activities.



From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

photo of team leader

Team Leader
Makito Miyazaki Ph.D.

Laboratory for Bottom-up Cell Biology



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Recruiting graduate students

Design principles for the self-organization of biological functions from molecules

The cell maintains its life through the assembly and disassembly of various subcellular structures having unique biological functions from molecules. How do the tiny molecules recognize the vast intracellular space and self-organize into micrometer-scale structures at appropriate time and space to regulate cell functions? This is a fundamental but non-trivial question in biology. Our team aims to understand the design principles that govern the self-organization of cell-scale ordered structures and biological functions from molecules. Using the cytoskeleton as a model system, we are exploring biochemical and physical conditions under which cytoskeletal structures and the related biological functions are reconstituted in artificial cells.

Selected Publications

Sakamoto R, Izri Z, Shimamoto Y, et al.
Geometric trade-off between contractile force and viscous drag determines the actomyosin-based motility of a cell-sized droplet.
Proceedings of the National Academy of Sciences of the United States of America 119(30), e2121147119 (2022) doi: 10.1073/pnas.2121147119

Sakamoto R, Tanabe M, Hiraiwa T, et al.
Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement.
Nature Communications 11(1), 3063 (2020) doi: 10.1038/s41467-020-16677-9

Kubota H, Miyazaki M, Ogawa T, et al.
Processive Nanostepping of Formin mDia1 Loosely Coupled with Actin Polymerization.
Nano Letters 18(10), 6617-6624 (2018) doi: 10.1021/acs.nanolett.8b03277

Kubota H, Miyazaki M, Ogawa T, et al.
Biphasic Effect of Profilin Impacts the Formin mDia1 Force-Sensing Mechanism in Actin Polymerization.
Biophysical Journal 113(2), 461-471 (2017) doi: 10.1016/j.bpj.2017.06.012

Suzuki K, Miyazaki M, Takagi J, et al.
Spatial confinement of active microtubule networks induces large-scale rotational cytoplasmic flow.
Proceedings of the National Academy of Sciences of the United States of America 114(11), 2922-2927 (2017) doi: 10.1073/pnas.1616001114

Miyazaki M, Chiba M, Eguchi H, et al.
Cell-sized spherical confinement induces the spontaneous formation of contractile actomyosin rings in vitro.
Nature Cell Biology 17(4), 480-489 (2015) doi: 10.1038/ncb3142

Chiba M, Miyazaki M, Ishiwata S.
Quantitative analysis of the lamellarity of giant liposomes prepared by the inverted emulsion method.
Biophysical Journal 107(2), 346-354 (2014) doi: 10.1016/j.bpj.2014.05.039


Makito Miyazaki

Team Leader