Team Leader
Takefumi Kondo
Ph.D.
Laboratory for Developmental Genome System
LocationKobe/ Developmental Biology Bldg.
E-mailtakefumi.kondo [at] riken.jp
Please replace [at] with @.
Our bodies are composed of multiple organs with appropriate "forms" and "functions." During animal development, epithelial tissues, which consist of a single layer of cell sheets, repeatedly grow and deform to shape an appropriate form. The function of an organ depends on the property of cells, and cells appropriately differentiate to fulfill the physiological roles of their constituent organs. These physical and biochemical processes proceed simultaneously. Therefore, to understand the self-organization mechanism in organogenesis, we believe that it is necessary to clarify the dynamics of both processes, how the two crosstalk spatiotemporally, and how this crosstalk achieves the harmony of form and function. Our laboratory aims to reveal the diversity and universality of feedback mechanisms across the genome-cell-tissue hierarchy by quantitatively analyzing the dynamics at each level using single-cell genomics, imaging techniques, and Drosophila genetics.
Selected Publications
Tsuboi A, Fujimoto K, Kondo T.
Spatio-temporal remodeling of extracellular matrix orients epithelial sheet folding.
Science Advances
9, eadh2154 Fri Sep 01 00:00:00 JST 2023
doi: 10.1126/sciadv.adh2154
Sakaguchi S, Okochi Y, Tanegashima C, et al.
Single-cell transcriptome atlas of Drosophila gastrula 2.0.
Cell Reports
42, 112707 Tue Jul 25 00:00:00 JST 2023
doi: 10.1016/j.celrep.2023.112707
Okochi Y, Sakaguchi S, Nakae K, et al.
Model-based prediction of spatial gene expression via generative linear mapping.
Nature Communications
12(1), 3731 Thu Jun 17 00:00:00 JST 2021
doi: 10.1038/s41467-021-24014-x
Kondo T, Hayashi S.
Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea.
eLife
8, e45145 Fri Aug 23 00:00:00 JST 2019
doi: 10.7554/eLife.45145
Kondo T, Hayashi S.
Mechanisms of cell height changes that mediate epithelial invagination.
Development, Growth & Differentiation
57(4), 313-323 Fri May 01 00:00:00 JST 2015
doi: 10.1111/dgd.12224
Kondo T, Sakuma T, Wada H, et al.
TALEN-induced gene knock out in Drosophila.
Development, Growth & Differentiation
56(1), 86-91 Wed Jan 01 00:00:00 JST 2014
doi: 10.1111/dgd.12097
Kondo T, Hayashi S.
Mitotic cell rounding accelerates epithelial invagination.
Nature
494(7435), 125-129 Thu Feb 07 00:00:00 JST 2013
doi: 10.1038/nature11792
Kondo T, Plaza S, Zanet J, et al.
Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis.
Science
329(5989), 336-339 Fri Jul 16 00:00:00 JST 2010
doi: 10.1126/science.1188158
Kondo T, Hashimoto Y, Kato K, et al.
Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA.
Nature Cell Biology
9(6), 660-665 Fri Jun 01 00:00:00 JST 2007
doi: 10.1038/ncb1595
Members
Team LeaderTakefumi Kondo
- takefumi.kondo[at]riken.jp
(Please replace [at] with @)
Research ScientistArisu Tsuboi
Technical ScientistMitsutaka Kadota
Technical ScientistOsamu Nishimura
Expert TechnicianChiharu Tanegashima
Technical Staff IIKaori Tatsumi
Technical Staff IDooseon Cho
AssistantSayo Saito
Student TraineeSonoko Mizuno
Student TraineeShutaro Endo
(Please replace [at] with @)