BDR researchers coming from diverse research fields are working together to achieve higher goals.

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BDR hosts annual symposium and regular seminars inviting international scientists in life science.

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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Team Leader Takefumi Kondo

Team Leader
Takefumi Kondo Ph.D.

Laboratory for Developmental Genome System

LocationKobe / Developmental Biology Buildings

Exploring feedback system harmonizing function and shape

Our bodies are composed of multiple organs with appropriate "forms" and "functions." During animal development, epithelial tissues, which consist of a single layer of cell sheets, repeatedly grow and deform to shape an appropriate form. The function of an organ depends on the property of cells, and cells appropriately differentiate to fulfill the physiological roles of their constituent organs. These physical and biochemical processes proceed simultaneously. Therefore, to understand the self-organization mechanism in organogenesis, we believe that it is necessary to clarify the dynamics of both processes, how the two crosstalk spatiotemporally, and how this crosstalk achieves the harmony of form and function. Our laboratory aims to reveal the diversity and universality of feedback mechanisms across the genome-cell-tissue hierarchy by quantitatively analyzing the dynamics at each level using single-cell genomics, imaging techniques, and Drosophila genetics.

Selected Publications

Tsuboi A, Fujimoto K, Kondo T.
Spatio-temporal remodeling of extracellular matrix orients epithelial sheet folding.
Science Advances 9, eadh2154 (2023) doi: 10.1126/sciadv.adh2154

Sakaguchi S, Okochi Y, Tanegashima C, et al.
Single-cell transcriptome atlas of Drosophila gastrula 2.0.
Cell Reports 42, 112707 (2021) doi: 10.1016/j.celrep.2023.112707

Okochi Y, Sakaguchi S, Nakae K, et al.
Model-based prediction of spatial gene expression via generative linear mapping.
Nature Communications 12(1), 3731 (2021) doi: 10.1038/s41467-021-24014-x

Kondo T, Hayashi S.
Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea.
eLife 8, e45145 (2019) doi: 10.7554/eLife.45145

Kondo T, Hayashi S.
Mechanisms of cell height changes that mediate epithelial invagination.
Development, Growth & Differentiation 57(4), 313-323 (2015) doi: 10.1111/dgd.12224

Kondo T, Sakuma T, Wada H, et al.
TALEN-induced gene knock out in Drosophila.
Development, Growth & Differentiation 56(1), 86-91 (2014) doi: 10.1111/dgd.12097

Kondo T, Hayashi S.
Mitotic cell rounding accelerates epithelial invagination.
Nature 494(7435), 125-129 (2013) doi: 10.1038/nature11792

Kondo T, Plaza S, Zanet J, et al.
Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis.
Science 329(5989), 336-339 (2010) doi: 10.1126/science.1188158

Kondo T, Hashimoto Y, Kato K, et al.
Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA.
Nature Cell Biology 9(6), 660-665 (2007) doi: 10.1038/ncb1595


Team Leader

Team LeaderTakefumi Kondo

  • takefumi.kondo[at]riken.jp
    (Please replace [at] with @)

Research ScientistArisu Tsuboi

Technical ScientistMitsutaka Kadota

Technical ScientistOsamu Nishimura

Expert TechnicianChiharu Tanegashima

Technical Staff IIKaori Tatsumi

Technical Staff IDooseon Cho

AssistantSayo Saito

Student TraineeSonoko Mizuno

Student TraineeShutaro Endo

(Please replace [at] with @)