Team Leader
Yumi Konagaya
Ph.D.
Laboratory for Quantitative Biology of Cell Fate Decision
LocationKobe / Developmental Biology Buildings
E-mailyumi.konagaya[at]riken.jp
Please replace [at] with @.
Tissue homeostasis relies on constant tissue renewal, notably within the rapidly regenerating intestinal epithelium. Precise control of cell proliferation during differentiation is critical for maintaining tissue homeostasis, as its disruptions lead to atrophy or cancer. Our research focuses on elucidating how cell proliferation and differentiation are orchestrated in the intestinal epithelium. In particular, we aim to uncover the molecular mechanisms underlying the cell fate decision of intestinal epithelial stem cells by live imaging of mouse intestinal organoids, multiplexed tissue imaging, and quantitative analyses.
An intestinal organoid expressing the cell cycle reporter FUCCI
Selected Publications
He J, Yamamoto M, Sumiyama K, et al.
Two-photon AMPK and ATP imaging reveals the bias between rods and cones in glycolysis utility.
FASEB Journal
35(9), e21880 Wed Sep 01 00:00:00 JST 2021
doi: 10.1096/fj.202101121R
Konagaya Y, Takakura K, Sogabe M, et al.
Intravital imaging reveals cell cycle-dependent myogenic cell migration during muscle regeneration.
Cell Cycle
19(22), 3167-3181 Sun Nov 01 00:00:00 JST 2020
doi: 10.1080/15384101.2020.1838779
Liu C, Konagaya Y, Chung M, et al.
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity.
Nature Communications
11(1), 5305 Tue Oct 20 00:00:00 JST 2020
doi: 10.1038/s41467-020-18966-9
Konagaya Y, Terai K, Hirao Y, et al.
A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs.
Cell Reports
21(9), 2628-2638 Tue Nov 28 00:00:00 JST 2017
doi: 10.1016/j.celrep.2017.10.113
Isoe Y, Konagaya Y, Yokoi S, et al.
Ontogeny and Sexual Differences in Swimming Proximity to Conspecifics in Response to Visual Cues in Medaka Fish.
Zoological Science
33(3), 246-254 Wed Jun 01 00:00:00 JST 2016
doi: 10.2108/zs150213
Members
Yumi Konagaya
Team Leader
Ayaka Omori
Technical Staff II
Miki Fujiwara
Assistant
