Laboratory for Chemical Biology | RIKEN BDR

Laboratory for Chemical Biology

Team Leader

Takamitsu HosoyaPh.D.

Photo of principal investigator

  • Location:Kobe / MI R&D Center Building
  • E-mail:takamitsu.hosoya[at]riken.jpPlease replace [at] with @.
  • Lab Website

Promotion of life science and drug discovery researches by world’s first innovative chemistries

Research Summary

In order to promote life science and drug discovery researches, it is necessary to develop new methods and tools based on innovative chemistries. Through collaboration researches with many scientists of different disciplines, we are trying to develop 1) useful molecular probes for in vivo imaging of target molecules, 2) novel synthetic strategies for functional molecular probes, 3) chemical tools and methods that facilitate chemical biology researches, and 4) efficient synthetic methods for valuable compounds.

Research Theme

  • Development of world’s first strategies for efficient molecular probe synthesis
  • Development of practical molecular probes specific for target molecules
  • Development of sequence specific chemical modification methods for biomolecular probe synthesis
  • Development of novel synthetic methods of valuable compounds

Main Publications List

  • Sato Y, Nakamura K, Sumida Y, et al.
    Generation of Alkyl Radical through Direct Excitation of Boracene-based Alkylborate.
    Journal of the American Chemical Society (2020) doi: 10.1021/jacs.0c04456
  • Uetake Y, Isoda M, Niwa T, Hosoya T.
    Synthesis of (2,2-diborylvinyl)arenes by rhodium-catalyzed desulfanylative gem-diborylation of 2-arylvinyl sulfides.
    Organic Letters 21, 4933–4938 (2019). doi: 10.1021/acs.orglett.9b01253
  • Niwa T, Ogoshi S, Hosoya T. et al.
    Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.
    Journal of the American Chemical Society 139 (36). 12855-12862 (2017) doi: 10.1021/jacs.7b08343
  • Hatakeyama M, Sakamoto Y, Ogata K, et al.
    A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.
    Physical Chemistry Chemical Physics 19 (39). 26926-26933 (2017) doi: 10.1039/C7CP04739H
  • Sumida Y, Sumida T, Hosoya T.
    Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides.
    Synthesis 49 (16). 3590-3601 (2017) doi: 10.1055/s-0036-1588464
  • Niwa T, Ochiai H, Isoda M, Hosoya T.
    Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters.
    Chemistry Letters 46 (9). 1315-1318 (2017) doi: 10.1246/cl.170549
  • Niwa T, Ochiai H, Hosoya T.
    Copper-Catalyzed ipso-Borylation of Fluoroarenes.
    ACS Catalysis 7 (7). 4535-4541 (2017) doi: 10.1021/acscatal.7b01448
  • Ochiai H, Uetake Y, Niwa T, Hosoya T.
    Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids.
    Angewandte Chemie International Edition 56 (9). 2482-2486 (2017) doi: 10.1002/anie.201611974
  • Ochiai H, Niwa T, Hosoya T.
    Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N -Dimethylformamide.
    Organic Letters 18 (23). 5982-5985 (2016) doi: 10.1021/acs.orglett.6b02675
  • Sumida Y, Sumida T, Hashizume D, Hosoya T.
    Preparation of Aryne-Nickel Complexes from ortho-Borylaryl Triflates.
    Organic Letters 18 (21). 5600-5603 (2016) doi: 10.1021/acs.orglett.6b02831
  • Uetake Y, Niwa T, Hosoya T.
    Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage.
    Organic Letters 18 (11). 2758-2761 (2016) doi: 10.1021/acs.orglett.6b01250
  • Niwa T, Ochiai H, Watanabe Y, Hosoya T.
    Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations.
    Journal of the American Chemical Society 137 (45). 14313-14318 (2015) doi: 10.1021/jacs.5b10119

All Publications


Takamitsu HosoyaTeam Leader takamitsu.hosoya[at] CV
Takashi NiwaDeputy Team Leader takashi.niwa[at] CV
Zhouen ZhangResearch Scientist zhang.zhouen[at] CV
Kenji WatanabeResearch Scientist kenji.watanabe.vs[at] CV
Tetsuya HoriSenior Research Scientist tetsuya.hori[at]
Daichi NakamuraTechnical Staff I
Junpei TsudaTemporary Staffing
Tadashi TakimotoTemporary Staffing
Asuka KuratsuTemporary Staffing
Tarou KohnoTemporary Staffing
Utano KawashimaAdministrative Part-time Worker II
Yuto SumidaVisiting Scientist
Isao KiiVisiting Scientist
Yuta UetakeVisiting Scientist
Yoko NagatomoAssistant*
Kimiko UtsumiAssistant*

*:concurrent / Please replace [at] with @.