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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

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Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

profile photo of the team leader

Team Leader
Takamitsu Hosoya Ph.D.

Laboratory for Chemical Biology

LocationKobe / MI R&D Center Building

E-mailtakamitsu.hosoya[at]riken.jp

Please replace [at] with @.

Promotion of life science and drug discovery researches by world’s first innovative chemistries

In order to promote life science and drug discovery researches, it is necessary to develop new methods and tools based on innovative chemistries. Through collaboration researches with many scientists of different disciplines, we are trying to develop 1) useful molecular probes for in vivo imaging of target molecules, 2) novel synthetic strategies for functional molecular probes, 3) chemical tools and methods that facilitate chemical biology researches, and 4) efficient synthetic methods for valuable compounds.

Research Theme

  • Development of world’s first strategies for efficient molecular probe synthesis
  • Development of practical molecular probes specific for target molecules
  • Development of sequence specific chemical modification methods for biomolecular probe synthesis
  • Development of novel synthetic methods of valuable compounds

Selected Publications

Sato Y, Nakamura K, Sumida Y, et al.
Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate.
Journal of the American Chemical Society 142(22), 9938-9943 (2020) doi: 10.1021/jacs.0c04456

Uetake Y, Isoda M, Niwa T, Hosoya T.
Synthesis of (2,2-diborylvinyl)arenes by rhodium-catalyzed desulfanylative gem-diborylation of 2-arylvinyl sulfides.
Organic Letters 21, 4933-4938 (2019) doi: 10.1021/acs.orglett.9b01253

Niwa T, Ogoshi S, Hosoya T. et al.
Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.
Journal of the American Chemical Society 139(36), 12855-12862 (2017) doi: 10.1021/jacs.7b08343

Hatakeyama M, Sakamoto Y, Ogata K, et al.
A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.
Physical Chemistry Chemical Physics 19(39), 26926-26933 (2017) doi: 10.1039/C7CP04739H

Sumida Y, Sumida T, Hosoya T.
Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides.
Synthesis 49(16), 3590-3601 (2017) doi: 10.1055/s-0036-1588464

Niwa T, Ochiai H, Isoda M, Hosoya T.
Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters.
Chemistry Letters 46(9), 1315-1318 (2017) doi: 10.1246/cl.170549

Niwa T, Ochiai H, Hosoya T.
Copper-Catalyzed ipso-Borylation of Fluoroarenes.
ACS Catalysis 7(7), 4535-4541 (2017) doi: 10.1021/acscatal.7b01448

Ochiai H, Uetake Y, Niwa T, Hosoya T.
Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids.
Angewandte Chemie International Edition 56(9), 2482-2486 (2017) doi: 10.1002/anie.201611974

Ochiai H, Niwa T, Hosoya T.
Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N -Dimethylformamide.
Organic Letters 18(23), 5982-5985 (2016) doi: 10.1021/acs.orglett.6b02675

Sumida Y, Sumida T, Hashizume D, Hosoya T.
Preparation of Aryne-Nickel Complexes from ortho-Borylaryl Triflates.
Organic Letters 18(21), 5600-5603 (2016) doi: 10.1021/acs.orglett.6b02831

Uetake Y, Niwa T, Hosoya T.
Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage.
Organic Letters 18(11), 2758-2761 (2016) doi: 10.1021/acs.orglett.6b01250

Niwa T, Ochiai H, Watanabe Y, Hosoya T.
Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations.
Journal of the American Chemical Society 137(45), 14313-14318 (2015) doi: 10.1021/jacs.5b10119

Members

Photo of Team leader

Team LeaderTakamitsu Hosoya

  • takamitsu.hosoya[at]riken.jp
    (Please replace [at] with @)

Concurrent Post: Professor, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

Research ScientistZhouen Zhang

  • zhang.zhouen[at]riken.jp
  • CV

Research ScientistKenji Watanabe

  • kenji.watanabe.vs[at]riken.jp

Senior Research ScientistTetsuya Hori

  • tetsuya.hori[at]riken.jp

Postdoctoral ResearcherDaichi Nakamura

Temporary StaffingJunpei Tsuda

Temporary StaffingTadashi Takimoto

Visiting ScientistTakashi Niwa

  • takashi.niwa[at]riken.jp

Visiting ScientistYuto Sumida

Visiting ScientistIsao Kii

Visiting ScientistYuta Uetake

Assistant*Yoko Nagatomo

Assistant*Kimiko Utsumi

(* Concurrent; Please replace [at] with @)

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