Team Leader
Takamitsu Hosoya
Ph.D.
Laboratory for Chemical Biology
[Closed Mar. 2025]
LocationKobe / MI R&D Center Building
E-mailtakamitsu.hosoya@riken.jp
In order to promote life science and drug discovery researches, it is necessary to develop new methods and tools based on innovative chemistries. Through collaboration researches with many scientists of different disciplines, we are trying to develop 1) useful molecular probes for in vivo imaging of target molecules, 2) novel synthetic strategies for functional molecular probes, 3) chemical tools and methods that facilitate chemical biology researches, and 4) efficient synthetic methods for valuable compounds.
Research Theme
- Development of world’s first strategies for efficient molecular probe synthesis
- Development of practical molecular probes specific for target molecules
- Development of sequence specific chemical modification methods for biomolecular probe synthesis
- Development of novel synthetic methods of valuable compounds
Selected Publications
Fukuchi T, Niwa T, Hosoya T, Watanabe Y.
Computational Study for Amino Acid Production from Carboxylic Acid via 14C β-decay.
Journal of the Physical Society of Japan
91, 064301 (2022)
doi: 10.7566/JPSJ.91.064301
Niwa T, Uetake Y, Isoda M, et al.
Lewis acid-mediated Suzuki–Miyaura cross-coupling reaction.
Nature Catalysis
4, 1080-1088 (2021)
doi: 10.1038/s41929-021-00719-6
Sato Y, Nakamura K, Sumida Y, et al.
Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate.
Journal of the American Chemical Society
142(22), 9938-9943 (2020)
doi: 10.1021/jacs.0c04456
Uetake Y, Isoda M, Niwa T, Hosoya T.
Synthesis of (2,2-diborylvinyl)arenes by rhodium-catalyzed desulfanylative gem-diborylation of 2-arylvinyl sulfides.
Organic Letters
21, 4933-4938 (2019)
doi: 10.1021/acs.orglett.9b01253
Niwa T, Ogoshi S, Hosoya T. et al.
Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.
Journal of the American Chemical Society
139(36), 12855-12862 (2017)
doi: 10.1021/jacs.7b08343
Hatakeyama M, Sakamoto Y, Ogata K, et al.
A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.
Physical Chemistry Chemical Physics
19(39), 26926-26933 (2017)
doi: 10.1039/C7CP04739H
Sumida Y, Sumida T, Hosoya T.
Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides.
Synthesis
49(16), 3590-3601 (2017)
doi: 10.1055/s-0036-1588464
Niwa T, Ochiai H, Isoda M, Hosoya T.
Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters.
Chemistry Letters
46(9), 1315-1318 (2017)
doi: 10.1246/cl.170549
Niwa T, Ochiai H, Hosoya T.
Copper-Catalyzed ipso-Borylation of Fluoroarenes.
ACS Catalysis
7(7), 4535-4541 (2017)
doi: 10.1021/acscatal.7b01448
Ochiai H, Uetake Y, Niwa T, Hosoya T.
Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids.
Angewandte Chemie International Edition
56(9), 2482-2486 (2017)
doi: 10.1002/anie.201611974
Ochiai H, Niwa T, Hosoya T.
Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N -Dimethylformamide.
Organic Letters
18(23), 5982-5985 (2016)
doi: 10.1021/acs.orglett.6b02675
Sumida Y, Sumida T, Hashizume D, Hosoya T.
Preparation of Aryne-Nickel Complexes from ortho-Borylaryl Triflates.
Organic Letters
18(21), 5600-5603 (2016)
doi: 10.1021/acs.orglett.6b02831
Uetake Y, Niwa T, Hosoya T.
Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage.
Organic Letters
18(11), 2758-2761 (2016)
doi: 10.1021/acs.orglett.6b01250
Niwa T, Ochiai H, Watanabe Y, Hosoya T.
Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations.
Journal of the American Chemical Society
137(45), 14313-14318 (2015)
doi: 10.1021/jacs.5b10119
Members
Team LeaderTakamitsu Hosoya
- takamitsu.hosoya[at]riken.jp
(Please replace [at] with @)
Concurrent Post: Professor, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Senior Scientist*Atsushi Iriki
Postdoctoral ResearcherDaichi Nakamura
Technical Staff IWakiko Arakaki
Temporary EmployeeYasuhiro Wada
Temporary EmployeeKayo Onoe
Temporary StaffingTadashi Takimoto
Senior Visiting ScientistYasuyoshi Watanabe
Senior Visiting ScientistYosky Kataoka
Senior Visiting ScientistHisashi Doi
Senior Visiting ScientistYi Long Cui
Senior Visiting ScientistKei Mizuno
Senior Visiting ScientistMitsuyo Maeda
Visiting ScientistTakashi Niwa
- takashi.niwa[at]a.riken.jp
Visiting ScientistYuto Sumida
Visiting ScientistIsao Kii
Visiting ScientistYuta Uetake
Visiting ScientistKenji Watanabe
Visiting ScientistHidefumi Mukai
Visiting ScientistKayo Takahashi
Visiting ScientistHiroshi Mizuma
Visiting ScientistKota Mori
Visiting ScientistShota Warashina
Visiting ScientistShoko Nomura
Visiting ScientistTsuyoshi Tahara
Visiting ScientistYasuhisa Tamura
Visiting ScientistMasanori Yamato
Visiting ScientistToshiyuki Goto
Visiting ScientistDi Hu
Visiting ScientistYuzuru Sato
Visiting ScientistHiroyuki Neyama
Visiting TechnicianShino Owada
Visiting TechnicianMaya Mitsuno
Visiting TechnicianSally Danno
Visiting TechnicianKumi Tsutsumi
Visiting TechnicianChie Ueta
Visiting TechnicianAsami Eguchi
Visiting TechnicianMayako Okamoto
Assistant*Yoko Nagatomo
(* Concurrent; Please replace [at] with @)
