logomark
Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Developing the organoid culture system for applied researches in adult tissue stem cells
Sep. 29, 2020 13:00 - 14:00

Category

Seminar

Place

Other

Venue

Online seminar

Speaker

Nobuo Sasaki

Affiliation

Keio University School of Medicine

Summary

Organoid is three-dimensional in vitro culture systems derived from self-organizing ES/iPS cells or adult tissue stem cells that mimic some of the structural and functional characteristics of an organ. This organoid technology has emerged as an invaluable tool to study stem cell biology, organogenesis, human pathologies including cancer and infection diseases over approximately the last decade. In fact, I have demonstrated that organoids can be used to identify niche for colonic stem cells, but also to understand intra-tumor heterogeneity in human colorectal cancer genetically and functionally at single-cell resolution. To open up possibilities of the organoid technology, I have also challenged the gut microbiology with human intestinal organoids to investigate the mechanism of direct interaction between host cells and anaerobic microbes. In this seminar, I will present recent our studies and discuss further potencies how we use organoids to drive state-of-the-art research with the aim to develop innovatively applications for organoid technology combined with a fascinating tool such as CRISPR/Cas9 based genome editing in human biology.

Host

Mitsuru Morimoto

PAGE
TOP