logomark
Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Mechano-chemical feedbacks in multicellular tissues underlying pattern formation and morphogenesis
Sep. 7, 2020 13:00 - 14:00

Category

Seminar

Place

Other

Venue

Online seminar

Speaker

Tsuyoshi Hirashima

Affiliation

Graduate School of Medicine, Kyoto University

Summary

How does a group of cells form complex patterns and architectures in a self-organized manner? To address this question, I have studied biophysical aspects of both the mechanical and biochemical regulations underlying multicellular tissue morphogenesis, using murine embryonic organs, live imaging, and mathematical modeling. In the seminar, I will focus on an interplay between active cellular forces and the mechano-sensitive MAP kinase ERK signaling, and provide several related topics including collective cell migration and branching morphogenesis. First, I will show a biophysical origin of collective cell migration and ERK activity waves in MDCK cells, and then discuss a close link to the cochlear duct development. Next, I will introduce a curvature-driven mechano-chemical feedback control exemplified in lung branching morphogenesis. Finally, I will talk a bit about the future extension, which hopefully enables us to integrate mechano-chemical feedbacks, multicellular pattern formation, and physiological function.

Host

Shigeo Hayashi

PAGE
TOP