Team Leader
Dan Ohtan Wang*
Ph.D.
Laboratory for Neuroepitranscriptomics
[Closed Mar. 2024]
*Current emailohtan.wang[at]nyu.edu
Please replace [at] with @.
The “brain” and “RNA” are the two keywords associated with our research. Using dynamic synapses and their association with intellectual ability, memory, and susceptibility to neurological disorders as the conceptual framework, we are studying the role of a novel RNA neuroepigenetic mechanism in the central nervous system in synapse function. The outcome of this quest will allow us to understand the regulatory mechanisms of gene networks for experience-based behavioral changes and diseases, over the course of our lifespan. Our research is supported by the current revolution in quantitative and omics technology, fluorescence imaging, and genetic animal model systems.
Research Theme
- Neurosciences
- Post-transcriptional regulation
- RNA chemical modification
Selected Publications
Madugalle SU, Meyer K, Wang DO, Bredy TW.
RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.
Trends in Neurosciences
43, 1011-1023 (2020)
doi: 10.1016/j.tins.2020.09.005
Roy R, Shiina N, Wang DO.
More dynamic, more quantitative, unexpectedly intricate: advanced understanding on synaptic RNA localization in learning and memory.
Neurobiology of Learning and Memory
168, 107149 (2020)
doi: 10.1016/j.nlm.2019.107149
Kashida S, Wang DO, Saito H, Gueroui Z.
Nanoparticle-based local translation reveals mRNA as translation-coupled scaffold with anchoring function.
Proceedings of the National Academy of Sciences of the United States of America
116(27), 13346-13351 (2019)
doi: 10.1073/pnas.1900310116
Wang DO.
Mapping m6A and m1A with mutation signatures.
Nature methods
16(12), 1213-1214 (2019)
doi: 10.1038/s41592-019-0636-z
Merkurjev D, Hong WT, Iida K, et al.
Synaptic N6 methyladenosine (m6A) reveals functional partitioning of localized transcripts.
Nature Neuroscience
21, 1004-1014 (2018)
doi: 10.1038/s41593-018-0173-6
Oomoto I, Suzuki-Hirano A, Umeshima H, et al.
ECHO-liveFISH: in vivo RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues.
Nucleic acids research
43(19), e126 (2015)
doi: 10.1093/nar/gkv614
Meer EJ, Wang DO, Kim S, et al.
Identification of a cis-acting element that localizes mRNA to synapses.
Proceedings of the National Academy of Sciences of the United States of America
109(12), 4639-4644 (2012)
doi: 10.1073/pnas.1116269109
Wang DO, Martin KC, Zukin RS.
Spatially restricting gene expression by local translation at synapses.
Trends in Neurosciences
33(4), 173-82 (2010)
doi: 10.1016/j.tins.2010.01.005
Wang DO, Kim SM, Zhao Y, et al.
Synapse- and stimulus-specific local translation during long-term neuronal plasticity.
Science
324(5934), 1536-40 (2009)
doi: 10.1126/science.1173205
