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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

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Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Dan Ohtan Wang

Team Leader
Dan Ohtan Wang Ph.D.

Laboratory for Neuroepitranscriptomics

LocationKobe / Developmental Biology Buildings

E-mailohtan[at]riken.jp

Please replace [at] with @.

The “brain” and “RNA” are the two keywords associated with our research. Using dynamic synapses and their association with intellectual ability, memory, and susceptibility to neurological disorders as the conceptual framework, we are studying the role of a novel RNA neuroepigenetic mechanism in the central nervous system in synapse function. The outcome of this quest will allow us to understand the regulatory mechanisms of gene networks for experience-based behavioral changes and diseases, over the course of our lifespan. Our research is supported by the current revolution in quantitative and omics technology, fluorescence imaging, and genetic animal model systems.

Research Theme

  • Neurosciences
  • Post-transcriptional regulation
  • RNA chemical modification

Selected Publications

Madugalle SU, Meyer K, Wang DO, Bredy TW.
RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.
Trends in Neurosciences 43, 1011-1023 (2020) doi: 10.1016/j.tins.2020.09.005

Roy R, Shiina N, Wang DO.
More dynamic, more quantitative, unexpectedly intricate: advanced understanding on synaptic RNA localization in learning and memory.
Neurobiology of Learning and Memory 168, 107149 (2020)

Kashida S, Wang DO, Saito H, Gueroui Z.
Nanoparticle-based local translation reveals mRNA as translation-coupled scaffold with anchoring function.
Proceedings of the National Academy of Sciences of the United States of America 116(27), 13346-13351 (2019)

Wang DO.
Mapping m6A and m1A with mutation signatures.
Nature methods 16(12), 1213-1214 (2019) doi: 10.1038/s41592-019-0636-z

Merkurjev D, Hong WT, Iida K, et al.
Synaptic N6 methyladenosine (m6A) reveals functional partitioning of localized transcripts.
Nature Neuroscience 21, 1004-1014 (2018)

Oomoto I, Suzuki-Hirano A, Umeshima H, et al.
ECHO-liveFISH: in vivo RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues.
Nucleic acids research 43(19), e126 (2015) doi: 10.1093/nar/gkv614

Meer E, Wang DO, Kim SM, et al.
Identification of a cis-element that localizes mRNA to synapses.
Proceedings of the National Academy of Sciences of the United States of America 109(12), 4639-44 (2012)

Wang DO, Martin KC, Zukin RS.
Spatially restricting gene expression by local translation at synapses.
Trends in Neurosciences 33(4), 173-82 (2010)

Wang DO, Kim SM, Zhao Y, et al.
Synapse- and stimulus-specific local translation during long-term neuronal plasticity.
Science 324(5934), 1536-40 (2009)

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