BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.



BDR communicates the appeal and significance of our research to society through the use of various media and activities.



From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Shunsuke Tagami

Team Leader
Shunsuke Tagami Ph.D.

Laboratory for Advanced Biomolecular Engineering



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Recruiting graduate students

We are developing biomacromolecules that control enzymes and cells

Research Theme

  • We are engineering peptides that control cells and enzymes for use in medical and basic science.
  • We are trying to experimentally reconstruct evolutional pathway from primordial peptides to elaborate proteins.

Selected Publications

Chaban A, Minakhin L, Goldobina E, et al.
Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail
Nature Communications (2024) doi: 10.1038/s41467-023-44630-z

Yagi S, Tagami S.
Missing-link fold reveals the evolutionary pathway between RNA polymerase and ribosomal proteins
bioRxiv (2022) doi: 10.1101/2023.07.05.547881

Mohri K, Huynh Nhat KP, Zouda M, et al.
Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin αvβ3 in tumor imaging
European Journal of Pharmaceutical Sciences (2022) doi: 10.1016/j.ejps.2022.106339

Alfi A, Popov A, Kumar A, et al.
Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2
ACS Synthetic Biology (2022) doi: 10.1021/acssynbio.2c00176

Li P, Holliger P, Tagami S.
Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion
Nature Communications 13, 3050 (2022) doi: 10.1038/s41467-022-30590-3

Yagi S, Padhi AK, Vucinic J, et al.
Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.
Journal of the American Chemical Society (2021) doi: 10.1021/jacs.1c05367

Sumida T, Dubiley S, Wilcox B, et al.
Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway.
ACS Chemical Biology., 14(7), 1619-1627 (2019) doi: 10.1021/acschembio.9b00348

Tagami S, Attwater J, Holliger P.
Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.
Nature Chemistry 9, 325-332 (2017) doi: 10.1038/nchem.2739

Tagami S, Sekine S, Minakhin L, et al.
Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes & Development 28(5), 521-531 (2014) doi: 10.1101/gad.233916.113

Tagami S, Sekine S, Kumarevel T, et al.
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.
Nature 468(7326), 978-982 (2010) doi: 10.1038/nature09573


Photo of Team leder, Shunsuke Tagami

Team LeaderShunsuke Tagami

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Senior Research ScientistAkira Wada

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Research ScientistAlmasul Alfi

  • almasul.alfi[at]riken.jp
  • CV
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Research ScientistPeiying Li

  • peiying.li[at]riken.jp
  • CV
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Postdoctoral ResearcherSubrata Dasgupta

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Visiting ScientistKazumasa Ohtake

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Visiting ScientistSota Yagi

  • sota.yagi[at]riken.jp
  • CV
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Junior Research AssociateTakuto Furuhashi

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Junior Research AssociateAleksandr Popov

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AssistantTami Kosuge

  • tami.kosuge[at]riken.jp

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