Team Leader
Shunsuke Tagami
Ph.D.
Laboratory for Advanced Biomolecular Engineering
LocationYokohama
E-mailshunsuke.tagami[at]riken.jp
Please replace [at] with @.
Research Theme
- We are engineering peptides that control cells and enzymes for use in medical and basic science.
- We are trying to experimentally reconstruct evolutional pathway from primordial peptides to elaborate proteins.
Selected Publications
Alfi A, Popov A, Kumar A, et al.
Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2
ACS Synthetic Biology
(2022)
doi: 10.1021/acssynbio.2c00176
Li P, Holliger P, Tagami S.
Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion
Nature Communications
13, 3050 (2022)
doi: 10.1038/s41467-022-30590-3
Yagi S, Padhi AK, Vucinic J, et al.
Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.
Journal of the American Chemical Society
(2021)
doi: 10.1021/jacs.1c05367
Sumida T, Dubiley S, Wilcox B, et al.
Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway.
ACS Chemical Biology.,
14(7), 1619-1627 (2019)
doi: 10.1021/acschembio.9b00348
Tagami S, Attwater J, Holliger P.
Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.
Nature Chemistry
9, 325-332 (2017)
doi: 10.1038/nchem.2739
Tagami S, Sekine S, Minakhin L, et al.
Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes & Development
28(5), 521-531 (2014)
doi: 10.1101/gad.233916.113
Tagami S, Sekine S, Kumarevel T, et al.
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.
Nature
468(7326), 978-982 (2010)
doi: 10.1038/nature09573
Members
Team LeaderShunsuke Tagami
- shunsuke.tagami[at]riken.jp
(Please replace [at] with @) - CV [PDF size：102KB]
