Laboratory for Advanced Biomolecular Engineering

Research Summary

We are engineering functional biomacromolecules applicable to medical and basic researches, by integrating technologies in synthetic and structural biology including peptide/RNA in vitro evolution, X-ray crystallography, etc. Utilizing the same technologies, we are also trying to reconstruct the evolutional pathway of primordial proteins.

Research Theme

• We are engineering peptides that control cells and enzymes for use in medical and basic science.
• We are trying to experimentally reconstruct evolutional pathway from primordial peptides to elaborate proteins.

Main Publications List

• Sumida T, Dubiley S, Wilcox B, et al.
  Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway.
  ACS Chemical Biology., 14(7), 1619-1627 (2019) doi: 10.1021/acschembio.9b00348
• Tagami S, Attwater J, Holliger P.
  Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.
  Nature Chemistry 9. 325-332 (2017) doi: 10.1038/nchem.2739.
• Tagami S, Sekine S, Minakhin L, et al.
  Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
  Genes & Development 28(5). 521-531 (2014) doi: 10.1101/gad.233916.113
• Tagami S, Sekine S, Kumarevel T, et al.
  Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.
  Nature 468(7326). 978-982 (2010) doi: 10.1038/nature09573

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