Team Leader
Shunsuke Tagami
Ph.D.
Laboratory for Advanced Biomolecular Engineering
LocationYokohama
E-mailshunsuke.tagami[at]riken.jp
Please replace [at] with @.
Research Theme
- We are engineering peptides that control cells and enzymes for use in medical and basic science.
- We are trying to experimentally reconstruct evolutional pathway from primordial peptides to elaborate proteins.
Selected Publications
Chaban A, Minakhin L, Goldobina E, et al.
Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail
Nature Communications
Fri Jan 05 00:00:00 JST 2024
doi: 10.1038/s41467-023-44630-z
Yagi S, Tagami S.
Missing-link fold reveals the evolutionary pathway between RNA polymerase and ribosomal proteins
bioRxiv
Mon Dec 05 00:00:00 JST 2022
doi: 10.1101/2023.07.05.547881
Mohri K, Huynh Nhat KP, Zouda M, et al.
Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin αvβ3 in tumor imaging
European Journal of Pharmaceutical Sciences
Thu Nov 24 00:00:00 JST 2022
doi: 10.1016/j.ejps.2022.106339
Alfi A, Popov A, Kumar A, et al.
Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2
ACS Synthetic Biology
Wed Jun 08 00:00:00 JST 2022
doi: 10.1021/acssynbio.2c00176
Li P, Holliger P, Tagami S.
Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion
Nature Communications
13, 3050 Fri Jun 03 00:00:00 JST 2022
doi: 10.1038/s41467-022-30590-3
Yagi S, Padhi AK, Vucinic J, et al.
Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.
Journal of the American Chemical Society
Fri Sep 24 00:00:00 JST 2021
doi: 10.1021/jacs.1c05367
Sumida T, Dubiley S, Wilcox B, et al.
Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway.
ACS Chemical Biology.,
14(7), 1619-1627 Sun Dec 01 00:00:00 JST 2019
doi: 10.1021/acschembio.9b00348
Tagami S, Attwater J, Holliger P.
Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.
Nature Chemistry
9, 325-332 Fri Dec 01 00:00:00 JST 2017
doi: 10.1038/nchem.2739
Tagami S, Sekine S, Minakhin L, et al.
Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes & Development
28(5), 521-531 Mon Dec 01 00:00:00 JST 2014
doi: 10.1101/gad.233916.113
Tagami S, Sekine S, Kumarevel T, et al.
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.
Nature
468(7326), 978-982 Wed Dec 01 00:00:00 JST 2010
doi: 10.1038/nature09573
Members
Team LeaderShunsuke Tagami
- shunsuke.tagami[at]riken.jp
(Please replace [at] with @) - CV [PDF size:102KB]
Senior Research ScientistAkira Wada
Research ScientistAlmasul Alfi
- almasul.alfi[at]riken.jp
- CV
Research ScientistPeiying Li
- peiying.li[at]riken.jp
- CV
Visiting ScientistKazumasa Ohtake
Visiting ScientistSota Yagi
- sota.yagi[at]riken.jp
- CV
Junior Research AssociateAleksandr Popov
Student TraineeTakuto Furuhashi
AssistantTami Kosuge
- tami.kosuge[at]riken.jp
(Please replace [at] with @)
News
Sep. 7, 2023 Research
How a widely used antimalarial drug affects zinc levels in a malarial parasite
Apr. 4, 2022 BDR News
Dive into BDR's intriguing research
Approaching the Origin of Life with Structural Biology
Jan. 27, 2022 Research
Plausible steps toward the evolution of a key protein fold of RNA polymerases