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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Shunsuke Tagami

Team Leader
Shunsuke Tagami Ph.D.

Laboratory for Advanced Biomolecular Engineering

LocationYokohama

E-mailshunsuke.tagami[at]riken.jp

Please replace [at] with @.

Recruiting graduate students

We are developing biomacromolecules that control enzymes and cells

Research Theme

  • We are engineering peptides that control cells and enzymes for use in medical and basic science.
  • We are trying to experimentally reconstruct evolutional pathway from primordial peptides to elaborate proteins.

Selected Publications

Chaban A, Minakhin L, Goldobina E, et al.
Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail
Nature Communications Fri Jan 05 00:00:00 JST 2024 doi: 10.1038/s41467-023-44630-z

Yagi S, Tagami S.
Missing-link fold reveals the evolutionary pathway between RNA polymerase and ribosomal proteins
bioRxiv Mon Dec 05 00:00:00 JST 2022 doi: 10.1101/2023.07.05.547881

Mohri K, Huynh Nhat KP, Zouda M, et al.
Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin αvβ3 in tumor imaging
European Journal of Pharmaceutical Sciences Thu Nov 24 00:00:00 JST 2022 doi: 10.1016/j.ejps.2022.106339

Alfi A, Popov A, Kumar A, et al.
Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2
ACS Synthetic Biology Wed Jun 08 00:00:00 JST 2022 doi: 10.1021/acssynbio.2c00176

Li P, Holliger P, Tagami S.
Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion
Nature Communications 13, 3050 Fri Jun 03 00:00:00 JST 2022 doi: 10.1038/s41467-022-30590-3

Yagi S, Padhi AK, Vucinic J, et al.
Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.
Journal of the American Chemical Society Fri Sep 24 00:00:00 JST 2021 doi: 10.1021/jacs.1c05367

Sumida T, Dubiley S, Wilcox B, et al.
Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway.
ACS Chemical Biology., 14(7), 1619-1627 Sun Dec 01 00:00:00 JST 2019 doi: 10.1021/acschembio.9b00348

Tagami S, Attwater J, Holliger P.
Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.
Nature Chemistry 9, 325-332 Fri Dec 01 00:00:00 JST 2017 doi: 10.1038/nchem.2739

Tagami S, Sekine S, Minakhin L, et al.
Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes & Development 28(5), 521-531 Mon Dec 01 00:00:00 JST 2014 doi: 10.1101/gad.233916.113

Tagami S, Sekine S, Kumarevel T, et al.
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.
Nature 468(7326), 978-982 Wed Dec 01 00:00:00 JST 2010 doi: 10.1038/nature09573

Members

Photo of Team leder, Shunsuke Tagami

Team LeaderShunsuke Tagami

member photo

Senior Research ScientistAkira Wada

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Research ScientistAlmasul Alfi

  • almasul.alfi[at]riken.jp
  • CV
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Research ScientistPeiying Li

  • peiying.li[at]riken.jp
  • CV
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Visiting ScientistKazumasa Ohtake

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Visiting ScientistSota Yagi

  • sota.yagi[at]riken.jp
  • CV
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Junior Research AssociateAleksandr Popov

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Student TraineeTakuto Furuhashi

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AssistantTami Kosuge

  • tami.kosuge[at]riken.jp

(Please replace [at] with @)

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