Membrane proteins play fundamental roles in many biological processes, and are recognized as principal target proteins for drug development. RNAs have become recognized asa novel remedy to solve the depletion of targets in drug development.Over the past decade, our structural understanding of biomolecules such as the membrane proteins and RNAshas dramatically progressed, owing to the growing numbers of their atomic resolution crystal and cryo-EM structures. However, these structures basically represent static snapshots and observed conformations may not be the same as those in in-situ environment. In this research team, by using NMR, which provides us information about dynamical structures of biomolecules in solution, we will investigate the relationships between the dynamical structures and the functions for biologically important biomolecules.
- Elucidation of functional mechanism of biomolecules from dynamic structures
- Elucidation of signal transduction mechanism of GPCRs from dynamic structures
- Development of methods for dynamic structures of membrane proteins in lipid bilayers
- Development of NMR methods applicable to high-molecular-weight biomolecules