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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

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Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

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Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

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BDR communicates the appeal and significance of our research to society through the use of various media and activities.

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About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Yosky Kataoka

Team Leader
Yosky Kataoka M.D., Ph.D.

Laboratory for Cellular Function Imaging

Location Kobe / MI R&D Center Building

Investigating the function and behavior of cells in living systems by imaging technologies

Many diseases including neurological disorders and malignancy were caused by dysfunction of cells and tissues in our body. The dysfunction is thought to be induced by chronic inflammation and functional deterioration of tissue repair in aging or fatigue.

We are investigating the dynamics and pathophysiological roles of stem/progenitor cells functioning in living tissues under aging or fatigue condition, by using multi-modal imaging technologies including PET, MRI, fluorescence/bioluminescence imaging, microendoscope imaging, electron microscope imaging. In particular, we are focusing on the functions of immunological regulation and tissue maintenance by stem/progenitor cells. Further, we aim to uncover the functional linkages among organs, tissues, and cells in aging, fatigue, malignancy and neurological disorders, by the combination of such imaging technologies and omics analyses. In addition, we are challenging to develop new medical technologies using light energy or plasma for analysis and manipulation of function of stem/progenitor cells, immune system, tissue repair, and regeneration.

Research Theme

  • Multi-modal imaging and functional analysis of stem/progenitor cells in vivo
  • Pathophysiological studies of aging and fatigue by imaging and omics analysis
  • Development of new technologies for analysis and control of bio-functions in vivo

Selected Publications

Sugita S, Yamato M, Hatabu T, Kataoka Y.
Involvement of cancer-derived EMT cells in the accumulation of 18F-fluorodeoxyglucose in the hypoxic cancer microenvironment.
Scientific Reports 11, 9668 (2021) doi: 10.1038/s41598-021-88414-1

Tamura Y, Takata K, Eguchi A, et al.
Age-related changes in NG2-expressing telocytes in rat stomach.
PLOS ONE 16(4), e0249729 (2021) doi: 10.1371/journal.pone.0249729

Konishi H, Okamoto T, Hara Y, et al.
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
EMBO Journal 39, e104464 (2020) doi: 10.15252/embj.2020104464

Kitami T, Fukuda S, Kato T, et al.
Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.
Scientific Reports 10, 19933 (2020) doi: 10.1038/s41598-020-77105-y

Tamura Y, Takata K, Eguchi A, Kataoka Y.
In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells.
Scientific Reports 8, 393 (2018) doi: 10.1038/s41598-017-18763-3

Nakano M, Tamura Y, Yamato M, et al.
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Scientific Reports 7, 42041 (2017) doi: 10.1038/srep42041

Yamano E, Sugimoto M, Hirayama A, et al.
Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.
Scientific Reports 6, 34990 (2016) doi: 10.1038/srep34990

Tamura Y, Takahashi K, Takata K, et al.
Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F] FLT-PET Imaging.
Journal of Neuroscience 36(31), 8123-8131 (2016) doi: 10.1523/JNEUROSCI.0220-16.2016

Iwawaki T, Akai R, Oikawa D, et al.
Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.
Scientific Reports 5, 17205 (2015) doi: 10.1038/srep17205

Kume S, Yamato M, Tamura Y, et al.
Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.
PLOS ONE 10(3), e0120106 (2015) doi: 10.1371/journal.pone.0120106

Members

Yosky Kataoka

Team Leader

Yasuhisa Tamura

Deputy Team Leader

Masanori Yamato

Research Scientist

Asami Eguchi

Technical Staff I

Kumi Takata

Technical Staff I

Sally Danno

Technical Staff I

Mayako Okamoto

Assistant

Kunpei Kawakatsu

Junior Research Associate

Mitsuyo Maeda

Senior Visiting Scientist

Kazuo Funabiki

Senior Visiting Scientist

Toshiyuki Goto

Visiting Scientist

Nozomu Kubota

Visiting Scientist

Chie Ueta

Visiting Technician

Yuki Okinaka

Student Trainee

Tomoka Akita

Research Part-time Worker II

Yoshika Seta

Research Part-time Worker II

Shizuka Kozaki

Research Part-time Worker II

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