Many diseases including neurological disorders and malignancy were caused by dysfunction of cells and tissues in our body. The dysfunction is thought to be induced by chronic inflammation and functional deterioration of tissue repair in aging or fatigue.
We are investigating the dynamics and pathophysiological roles of stem/progenitor cells functioning in living tissues under aging or fatigue condition, by using multi-modal imaging technologies including PET, MRI, fluorescence/bioluminescence imaging, microendoscope imaging, electron microscope imaging. In particular, we are focusing on the functions of immunological regulation and tissue maintenance by stem/progenitor cells. Further, we aim to uncover the functional linkages among organs, tissues, and cells in aging, fatigue, malignancy and neurological disorders, by the combination of such imaging technologies and omics analyses. In addition, we are challenging to develop new medical technologies using light energy or plasma for analysis and manipulation of function of stem/progenitor cells, immune system, tissue repair, and regeneration.
- Multi-modal imaging and functional analysis of stem/progenitor cells in vivo
- Pathophysiological studies of aging and fatigue by imaging and omics analysis
- Development of new technologies for analysis and control of bio-functions in vivo