Laboratory for Cellular Function Imaging
Yosky KataokaM.D., Ph.D.
- Location：Kobe / MI R&D Center Building
- E-mail：kataokay[at]riken.jpPlease replace [at] with @.
Investigating the function and behavior of cells in living systems by imaging technologies
Many diseases including neurological disorders and malignancy were caused by dysfunction of cells and tissues in our body. The dysfunction is thought to be induced by chronic inflammation and functional deterioration of tissue repair in aging or fatigue.
We are investigating the dynamics and pathophysiological roles of stem/progenitor cells functioning in living tissues under aging or fatigue condition, by using multi-modal imaging technologies including PET, MRI, fluorescence/bioluminescence imaging, microendoscope imaging, electron microscope imaging. In particular, we are focusing on the functions of immunological regulation and tissue maintenance by stem/progenitor cells. Further, we aim to uncover the functional linkages among organs, tissues, and cells in aging, fatigue, malignancy and neurological disorders, by the combination of such imaging technologies and omics analyses. In addition, we are challenging to develop new medical technologies using light energy or plasma for analysis and manipulation of function of stem/progenitor cells, immune system, tissue repair, and regeneration.
Multi-modal imaging for stem/progenitor cells
New technology for multi-modal imaging with electron microscopy and dig data analysis of morphological feature
Multi-omics analyses including imaging big data obtained by electron microscopy
- Multi-modal imaging and functional analysis of stem/progenitor cells in vivo
- Pathophysiological studies of aging and fatigue by imaging and omics analysis
- Development of new technologies for analysis and control of bio-functions in vivo
Main Publications List
- Tamura Y, Takata K, Eguchi A, Kataoka Y.
In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells.
Scientific Reports 8. 393 (2018) doi: 10.1038/s41598-017-18763-3
- Kume S, Nishimura Y, Mizuno K, et al.
Music Improves Subjective Feelings Leading to Cardiac Autonomic Nervous Modulation: A Pilot Study.
Frontiers in Neuroscience 11. 108 (2017) doi: 10.3389/fnins.2017.00108
- Nakano M, Tamura Y, Yamato M, et al.
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Scientific Reports 7. 42041 (2017) doi: 10.1038/srep42041
- Yamano E, Sugimoto M, Hirayama A, et al.
Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.
Scientific Reports 6. 34990 (2016) doi: 10.1038/srep34990
- Tamura Y, Takahashi K, Takata K, et al.
Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F] FLT-PET Imaging.
Journal of Neuroscience 36(31). 8123-8131 (2016) doi: 10.1523/JNEUROSCI.0220-16.2016
- Iwawaki T, Akai R, Oikawa D, et al.
Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.
Scientific Reports 5. 17205 (2015) doi: 10.1038/srep17205
- Kume S., Yamato M., Tamura Y, et al.
Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.
PLOS ONE 10(3). e0120106 (2015) doi: 10.1371/journal.pone.0120106
- Cui YL, Toyoda H, Sako T, et al.
A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.
Neuroimage 108. 17-22 (2015) doi: 10.1016/j.neuroimage.2014.12.047
- Nakatomi Y, Mizuno K, Ishii A, et al.
Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.
Journal of Nuclear Medicine 55(6). 945-950 (2014) doi: 10.2967/jnumed.113.131045
- Yamato, M., Tamura, Y., Eguchi, A., Watanabe, Y., and Kataoka, Y.
Brain interleukin-1beta and the intrinsic receptor antagonist control peripheral toll-like receptor 3-mediated suppression of spontaneous activity in rats.
PLOS ONE 9. e90950 (2014) doi: 10.1371/journal.pone.0090950
|Yosky KataokaTeam Leader||kataokay[at]riken.jp|
|Yasuhisa TamuraDeputy Team Leader||tamuray[at]riken.jp|
|Masanori YamatoResearch Scientist||yamatomasa[at]riken.jp|
|Satoshi KumeResearch Scientist||satoshi.kume[at]riken.jp|
|Kumi TakataTechnical Staff I|
|Asami EguchiTechnical Staff I|
|Sally DannoTechnical Staff I|
|Guihua ChenResearch Part-time Worker I|
|Toshiyuki GotoResearch Part-time Worker II|
|Riho MashibaResearch Part-time Worker II|
|Seika AoyamaAdministrative Part-time Worker II|
|Yuka WatahikiAdministrative Part-time Worker II|
|Kunpe KawakatsuAdministrative Part-time Worker II|
|Kazuo FunabikiSenior Visiting Scientist|
*：concurrent / Please replace [at] with @.