Team Director
Ryoichiro Kageyama M.D., Ph.D.

Isomura A, Kageyama R.
Progress in understanding the vertebrate segmentation clock
Nature Reviews Genetics (2025) doi: 10.1038/s41576-025-00813-6

Shimojo H, Masaki T, Kageyama R.
The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.
Developmental Cell 59(15), 1913-1923 (2024) doi: 10.1016/j.devcel.2024.04.019

Maeda Y, Isomura A, Masaki T, Kageyama R.
Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21.
Cell Reports 42(5), 112520 (2023) doi: 10.1016/j.celrep.2023.112520

Kageyama R.
In retrospect: 25 years of the segmentation clock gene
Nature 611, 671-673 (2022) doi: 10.1038/d41586-022-03562-2

Kaise T, Fukui M, Sueda R, et al.
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity
Genes and Development 36, 23-37 (2022) doi: 10.1101/gad.349000.121

Matsuda M, Hayashi H, Garcia-Ojalvo J, et al.
Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Science 369(6510), 1450-1455 (2020) doi: 10.1126/science.aba7668

Yoshioka-Kobayashi K, Matsumiya M, Niino Y, et al.
Coupling delay controls synchronized oscillation in the segmentation clock.
Nature 580(7801), 119-123 (2020) doi: 10.1038/s41586-019-1882-z

Diaz-Cuadros M, Wagner DE, Budjan C, et al.
In vitro characterization of the human segmentation clock.
Nature 580(7801), 113-118 (2020) doi: 10.1038/s41586-019-1885-9

Sueda R, Imayoshi I, Harima Y, Kageyama R.
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain.
Genes & Development 33(9-10), 511-523 (2019) doi: 10.1101/gad.323196.118

Kawaguchi K, Kageyama R, Sano M.
Topological defects control collective dynamics in neural progenitor cell cultures.
Nature 545(7654), 327-331 (2017) doi: 10.1038/nature22321