logomark
Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Takuya Hayashi

Team Leader
Takuya Hayashi M.D., Ph.D.

Laboratory for Brain Connectomics Imaging


Location Kobe / MI R&D Center

E-mailtakuya.hayashi[at]riken.jp

Please replace [at] with @.

Dissecting brain function, architecture and connectivity –brain connectome

Our laboratory develops neuroimaging research techniques using magnetic resonance imaging (MRI) to comprehensively understand organization of brain function, structure, connectivity (brain connectome) in human and non-human primates. By visualizing the living brains, we investigate how development, aging, evolution, social behaviors, genetics, environments, dysfunction, and plasticity are represented in the dynamics and reorganization of the brain system. Strength of noninvasive imaging methods is that it allows us to observe brain systems across individuals, time and species, which may provide us a clue to understand how individual variability is formed, how we develop and spend our life, and how brains have evolved across primate species. However, quality of noninvasive imaging methods including MRI is often hampered by its limited resolution and addressing neurobiological findings is easily contaminated by various artifacts originated from living organs. Observed findings rarely have direct link to those found in traditional neuroscientific methods (microscopy, electrophysiology) – electromagnetic phenomenon visualized by MRI must be translated into those of neurobiological events.

Our lab has developeda high-resolution imaging system to visualize functional anatomy of non-human primate brains.This was achieved by combination of various technical developments including high-resolution signal detection, accelerated imaging, modelling, noise reduction and accurate mapping. Our development achieved the highly sensitive and reliable estimation of functional connectivity as compared with any other research facilities, thereby we advance the international research project for non-human primate neuroimaging and neuroanatomy (NHP_NNP). This project aims to harmonize the MRI technologies between NHP and humans, and to understand the general principle of the primate brain organization and pathophysiology in the primate animal models of human brain diseases. We make use of our developments in NHP for human brain imaging for understanding brain system and diseases, which is supported by a Brain/MINDS-beyond project. Our research and technology are based on close domestic and international collaborations. Please do not hesitate to contact us if you would work together with us to develop brain MRI techniques and understand the brain functional anatomy, plasticity, and pathology.

Primate Connectome MRI scanner installed in RIKEN Kobe (left) and our developed radiofrequency receiving coil and brain/head images of non-human primates (right)

Our lab for brain connectomicsimaging aims to visualize brain structure, function and connectivity using MRI and to comprehensive understanding of dynamics of brains in human and non-human primates

Research Theme

  • Visualization of brain connectomics
  • Reorganization of brain network in regeneration
  • Reorganization of brain network in plasticity
  • Sociality, brain network and neurotransmitter

Selected Publications

Hayashi T, Hou Y, Glasser MF, et al.
The nonhuman primate neuroimaging and neuroanatomy project.
NeuroImage 229, 117726 (2021) doi: 10.1016/j.neuroimage.2021.117726

Autio JA, Glasser MF, Ose T, et al.
Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing.
NeuroImage 215, 116800 (2020) doi: 10.1016/j.neuroimage.2020.116800

Aso T, Sugihara G, Murai T, et al.
A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing.
Brain : a journal of neurology 143(6), 1843-1856 (2020) doi: 10.1093/brain/awaa125

Fukutomi H, Glasser MF, Zhang H, et al.
Neurite imaging reveals microstructural variations in human cerebral cortical gray matter.
NeuroImage 182, 488-499 (2018) doi: 10.1016/j.neuroimage.2018.02.017

Morizane A, Kikuchi T, Hayashi T, et al.
MHC matching improves engraftment of iPSC-derived neurons in non-human primates.
Nature Communication 8, 385 (2017) doi: 10.1038/s41467-017-00926-5

Kikuchi T, Morizane A, Doi D, et al.
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model.
Nature 548, 592-596 (2017) doi: 10.1038/nature23664

Takenobu Y, Hayashi T, Moriwaki H, et al.
Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke.
NeuroImage: Clinical 14, 201-208 (2014) doi: 10.1016/j.nicl.2013.12.003

Yokoyama C, Kawasaki A, Hayashi T, et al.
Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets.
Cerebral Cortex 23(9), 2136-2145 (2013) doi: 10.1093/cercor/bhs196

Hayashi T, Ko JH, Strafella AP, et al.
Dorsolateral prefrontal and orbitofrontal cortex interactions during self-control of cigarette craving.
Proceedings of the National Academy of Sciences of the United States of America 110(11), 4422-4427 (2013) doi: 10.1073/pnas.1212185110

Hayashi T, Wakao S, Kitada M, et al.
Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.
Journal of Clinical Investigation 123(1), 272-284 (2013) doi: 10.1172/JCI62516

Hayashi T, Shimazawa M, Watabe H, et al.
Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma.
Molecular neurodegeneration 8, 4 (2013) doi: 10.1186/1750-1326-8-4

Ikoma Y, Watabe H, Hayashi T, et al.
Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 30(3), 663-73 (2010) doi: 10.1038/jcbfm.2009.239

Takagi Y, Takahashi J, Saiki H, et al.
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.
Journal of Clinical Investigation 115(1), 102-109 (2005) doi: 10.1172/JCI21137

Members

Takuya Hayashi

Team Leader

Toshihiko Aso

Deputy Team Leader

Joonas Autio

Senior Scientist

Kyosuke Watanabe

Research Scientist

Takuro Ikeda

Research Scientist

Akiko Uematsu

Research Scientist

Akihiro Kawasaki

Technical Scientist

Chiho Takeda

Technical Scientist

Takashi Azuma

Technical Scientist

Takayuki Ose

Expert Technician

Masahiro Ohno

Expert Technician

Yuki Matsumoto

Technical Staff I

Reiko Kobayashi

Technical Staff I

PAGE
TOP