[Student Organized Seminar] Multicellular autonomy in stem cell culture Aug. 30, 2021 13:30 - 15:00
This seminar is open only to BDR members.
Pluripotent stem cells (such as ES cells and iPS cells) can, in principle, differentiate into all cell types that make up our body. In a last decade, a technology that induces the differentiation of pluripotent stem cells into desired cell types by mimicking the environment of the developing organ in a culture dish has greatly developed. We have developed a method to induce various neural regions such as cerebral cortical tissue and retinal tissue from pluripotent stem cells (cerebral organoids and retinal organoids), and have studied the molecular basis of self-organization in the pattern formation and morphogenesis. In this talk, I will introduce a new means to form a tissue with the function as a circadian clock center, capable of sustaining stable clock gene oscillations in a 24-hour cycle for more than 20 days in stem cell culture. In addition, I will talk about induction of human olfactory sensory epithelium organoids and its application to elucidate the mechanism of olfactory abnormality caused by SARS-CoV2 infection.