Mechano-chemical feedbacks in multicellular tissues underlying pattern formation and morphogenesis
Sep. 7, 2020 13:00 - 14:00
Graduate School of Medicine, Kyoto University
How does a group of cells form complex patterns and architectures in a self-organized manner? To address this question, I have studied biophysical aspects of both the mechanical and biochemical regulations underlying multicellular tissue morphogenesis, using murine embryonic organs, live imaging, and mathematical modeling. In the seminar, I will focus on an interplay between active cellular forces and the mechano-sensitive MAP kinase ERK signaling, and provide several related topics including collective cell migration and branching morphogenesis. First, I will show a biophysical origin of collective cell migration and ERK activity waves in MDCK cells, and then discuss a close link to the cochlear duct development. Next, I will introduce a curvature-driven mechano-chemical feedback control exemplified in lung branching morphogenesis. Finally, I will talk a bit about the future extension, which hopefully enables us to integrate mechano-chemical feedbacks, multicellular pattern formation, and physiological function.