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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Dan Ohtan Wang

Team Leader
Dan Ohtan Wang Ph.D.

Laboratory for Neuroepitranscriptomics

LocationKobe / Developmental Biology Buildings

E-mailohtan[at]riken.jp

Please replace [at] with @.

The “brain” and “RNA” are the two keywords associated with our research. Using dynamic synapses and their association with intellectual ability, memory, and susceptibility to neurological disorders as the conceptual framework, we are studying the role of a novel RNA neuroepigenetic mechanism in the central nervous system in synapse function. The outcome of this quest will allow us to understand the regulatory mechanisms of gene networks for experience-based behavioral changes and diseases, over the course of our lifespan. Our research is supported by the current revolution in quantitative and omics technology, fluorescence imaging, and genetic animal model systems.

Research Theme

  • Neurosciences
  • Post-transcriptional regulation
  • RNA chemical modification

Selected Publications

Madugalle SU, Meyer K, Wang DO, Bredy TW.
RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.
Trends in Neurosciences 43, 1011-1023 Tue Dec 01 00:00:00 JST 2020 doi: 10.1016/j.tins.2020.09.005

Roy R, Shiina N, Wang DO.
More dynamic, more quantitative, unexpectedly intricate: advanced understanding on synaptic RNA localization in learning and memory.
Neurobiology of Learning and Memory 168, 107149 Thu Oct 01 00:00:00 JST 2020 doi: 10.1016/j.nlm.2019.107149

Kashida S, Wang DO, Saito H, Gueroui Z.
Nanoparticle-based local translation reveals mRNA as translation-coupled scaffold with anchoring function.
Proceedings of the National Academy of Sciences of the United States of America 116(27), 13346-13351 Sun Dec 01 00:00:00 JST 2019 doi: 10.1073/pnas.1900310116

Wang DO.
Mapping m6A and m1A with mutation signatures.
Nature methods 16(12), 1213-1214 Sun Dec 01 00:00:00 JST 2019 doi: 10.1038/s41592-019-0636-z

Merkurjev D, Hong WT, Iida K, et al.
Synaptic N6 methyladenosine (m6A) reveals functional partitioning of localized transcripts.
Nature Neuroscience 21, 1004-1014 Sat Dec 01 00:00:00 JST 2018 doi: 10.1038/s41593-018-0173-6

Oomoto I, Suzuki-Hirano A, Umeshima H, et al.
ECHO-liveFISH: in vivo RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues.
Nucleic acids research 43(19), e126 Fri Oct 30 00:00:00 JST 2015 doi: 10.1093/nar/gkv614

Meer EJ, Wang DO, Kim S, et al.
Identification of a cis-acting element that localizes mRNA to synapses.
Proceedings of the National Academy of Sciences of the United States of America 109(12), 4639-4644 Tue Mar 20 00:00:00 JST 2012 doi: 10.1073/pnas.1116269109

Wang DO, Martin KC, Zukin RS.
Spatially restricting gene expression by local translation at synapses.
Trends in Neurosciences 33(4), 173-82 Wed Dec 01 00:00:00 JST 2010 doi: 10.1016/j.tins.2010.01.005

Wang DO, Kim SM, Zhao Y, et al.
Synapse- and stimulus-specific local translation during long-term neuronal plasticity.
Science 324(5934), 1536-40 Tue Dec 01 00:00:00 JST 2009 doi: 10.1126/science.1173205

Members

Dan Ohtan Wang

Team Leader

Kotaro Mizuta

Senior Scientist

Sefan Asamitsu

Visiting Researcher

Loic Christian Broix

Visiting Researcher

Sarayut Phasuk

Postdoctoral Researcher

Shengqun Hou

Junior Research Associate

Momoe Sukegawa

Student Trainee

Kangwei Zheng

Student Trainee

Erdong Zhou

Student Trainee

Wan-Ting Hong

Junior Research Associate

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