
About UsMission
Toward a healthy, long-lived society by looking beyond “understanding” the life cycle to “predict” and actively “control” life cycle outcomes

In a country like Japan facing declining birthrates and a super aging society, one of the most pressing issues at hand is how to achieve a society in which citizens of all ages can grow and age healthily, and there is a need for new scientific knowledge and technology to enable humans to maintain a healthy state throughout life.
At the Center for Biosystems Dynamics Research (BDR), we view the life course—from development to birth, to growth and to aging—as a continuous sequence, and employ an integrative approach, leveraging techniques and technologies related to cells, organoids, molecular biology, synthetic biology, diverse animal models, multiscale imaging and quantification, theoretical biology, AI models, robotics, and multiscale simulations. We are promoting the following three pillars of research.
Understanding: To understand the life course across spatiotemporal scales by utilizing BDR’s strengths such as state-of-the-art imaging and quantification technologies and access to diverse animal models.
Prediction: To predict progression of the life cycle using AI, foundation models, mathematical models, and simulation technologies that are based on the extensive data amassed from imaging and quantification technologies.
Control: To gain new insights and develop technology for maintaining healthy states of organisms during stages of development, growth, and aging, using technologies that can serve as models for living organisms, such as organoids.
We will promote these research approaches synergistically, developing technologies and further expanding our scientific knowledge base for maintaining healthy states of individuals through cross-cutting understanding of biological processes across multiple scales, technological developments for life cycle prediction, and unveiling of new insights and technological developments for life cycle control. Through these approaches, we aim to contribute to achieving a healthy, long-lived society as well as the advancement of life sciences.
Ryoichiro Kageyama
Director
