Team Leader
Masayuki Oginuma
Ph.D.
Chrono-Developmental Biology RIKEN ECL Research Team
LocationKobe / Developmental Biology Buildings
E-mailmasayuki.oginuma[at]riken.jp
Please replace [at] with @.
Organisms possess a remarkable "blueprint of time." Embryonic development, from fertilization to the processes of body formation, follows a precise schedule regulated by a clock mechanism encoded in the genes. However, the specific underlying molecular mechanisms remains largely unknown. The turquoise killifish, N. furzeri, which inhabit the ephemeral ponds in Africa, can suspend their embryonic development and enter a state of diapause for extended periods.
Our lab aims to clarify the mechanisms of diapause, a highly evolved developmental clock-stopping phenomenon. We have developed a method that allows us to rapidly and easily analyze the dynamics and functions of turquoise killifish genes, and using this method, we will investigate the function of genes that regulate embryonic time to reveal the complete picture of the "blueprint of time," and applying our findings to other organisms.
Selected Publications
Oginuma M, Nishida M, Ohmura-Adachi T, et al.
Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging.
Scientific Reports
12(1), 11628 Fri Jul 08 00:00:00 JST 2022
doi: 10.1038/s41598-022-15972-3
Oginuma M, Harima Y, Tarazona OA, et al.
Intracellular pH controls WNT downstream of glycolysis in amniote embryos.
Nature
584(7819), 98-101 Sat Aug 01 00:00:00 JST 2020
doi: 10.1038/s41586-020-2428-0
Zhao W, Oginuma M, Ajima R, et al.
Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis.
eLife
7, e33068 Tue May 15 00:00:00 JST 2018
doi: 10.7554/eLife.33068
Oginuma M, Moncuquet P, Xiong F, et al.
A Gradient of Glycolytic Activity Coordinates FGF and Wnt Signaling during Elongation of the Body Axis in Amniote Embryos.
Developmental Cell
40(4), 342-353 Mon Feb 27 00:00:00 JST 2017
doi: 10.1016/j.devcel.2017.02.001
Chal J, Oginuma M, Al Tanoury Z, et al.
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.
Nature Biotechnology
33(9), 962-969 Tue Sep 01 00:00:00 JST 2015
doi: 10.1038/nbt.3297
Oginuma M, Takahashi Y, Kitajima S, et al.
The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.
Development
137(9), 1515-1522 Sat May 01 00:00:00 JST 2010
doi: 10.1242/dev.044545
Oginuma M, Hirata T, Saga Y.
Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technology.
Mechanisms of Development
125(5-6), 432-440 Mon Dec 01 00:00:00 JST 2008
doi: 10.1016/j.mod.2008.01.010
Oginuma M, Niwa Y, Chapman DL, Saga Y.
Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis.
Development
135(15), 2555-2562 Fri Aug 01 00:00:00 JST 2008
doi: 10.1242/dev.019877