Team Leader
Fumiaki Obata
Ph.D.
Laboratory for Nutritional Biology
LocationKobe / Developmental Biology Buildings
E-mailfumiaki.obata[at]riken.jp
Please replace [at] with @.
The organismal healthspan is significantly influenced by the quality and quantity of the diet, but our understanding of the detailed molecular mechanisms remains limited. In our laboratory, we study the physiological functions of various nutrients during each life stage, including development, growth, reproduction, and aging. We aim to elucidate the adaptive mechanisms in response to nutritional imbalances, whether transient or chronic, and their impact on molecular mechanisms related to metabolic physiology, tissue homeostasis, feeding behavior, stress response, reproductive capacity, and overall lifespan.
Research Themes
- Lifespan Extension through Dietary Restriction
- Specific Sensing of Nutrients and the Adaptive Mechanism to their Deficiency
- Healthspan Changes by Early-life Dietary Environment
- Blood-feeding Behavior and Metabolic Homeostasis in Mosquitoes
Selected Publications
Kosakamoto H, Miura M, Obata F.
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila.
Development
151(1), dev202372 Mon Jan 01 00:00:00 JST 2024
doi: 10.1242/dev.202372
Kosakamoto H, Obata F, Kuraishi J, et al.
Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila.
Nature Communications
14(1), 7832 Tue Dec 05 00:00:00 JST 2023
doi: 10.1038/s41467-023-43550-2
Onuma T, Yamauchi T, Kosakamoto H, et al.
Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.
PLOS Genetics
19(4), e1010709 Sat Apr 01 00:00:00 JST 2023
doi: 10.1371/journal.pgen.1010709
Kosakamoto H, Okamoto N, Aikawa H, et al.
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.
Nature Metabolism
4(7), 944-959 Fri Jul 01 00:00:00 JST 2022
doi: 10.1038/s42255-022-00608-7
Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience
23, 101477 Wed Sep 02 00:00:00 JST 2020
doi: 10.1016/j.isci.2020.101477
Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports
32(3), 107938 Tue Jul 21 00:00:00 JST 2020
doi: 10.1016/j.celrep.2020.107938
Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell
44(6), 741-751 Mon Mar 26 00:00:00 JST 2018
doi: 10.1016/j.devcel.2018.02.017
Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications
9(1), 975 Wed Mar 07 00:00:00 JST 2018
doi: 10.1038/s41467-018-03070-w
News
Mar. 26, 2024 Research
Flies fed restricted diet in early adulthood live longer
Mar. 15, 2024 BDR News
Dive into BDR's intriguing research
The Desire to Explain Nutrition Properly
Jul. 28, 2023 Research
How a gut microbe causes flies to live fast and die young
Oct. 17, 2022 Research
‘Non-essential’ building block proves vital to a healthy protein diet
Apr. 12, 2021 BDR News
Five new laboratories join RIKEN BDR