ロゴマーク
研究

研究

BDRでは、様々な分野の研究者が協力して、より高い目標に向かって研究を進めています。

セミナー・シンポジウム

セミナー・イベント

BDRでは、ライフサイエンス分野の国際的な研究者を招いて、年1回のシンポジウムや定期的なセミナーを開催しています。

働く・学ぶ

働く・学ぶ

BDRでは、様々なバックグラウンドを持つ人々を受け入れ、オープンで協力的な研究環境の構築に努めています。

つながる・楽しむ

つながる・楽しむ

BDRでは、様々なメディアや活動を通じて、研究の魅力や意義を社会に発信しています。

ニュース

ニュース

最新の研究、イベント、研究者のインタビューなど、理研BDRの最新情報をお届けします。

BDRについて

BDRについて

理研の強みを生かし学際的なアプローチで生命の根源を探求し、社会の課題に応えます。

業績一覧 | 上皮形態形成研究チーム 

業績一覧

Thukral S, Dey P, Kaity B, et al.
Dynamic microtubules drive yolk-cytoplasm segregation in the syncytial Drosophila embryo
bioRxiv (2026) doi: 10.64898/2026.09.02.748760

Huang T-Y, Lemke S, Wang Y-C.
Morphogenetic evolution with physical influences
Seminars in Cell & Developmental Biology (2026) doi: https://doi.org/10.1016/j.semcdb.2026.103671

Kwan CW, Sakaguchi S, Takeda M, et al.
Cell-intrinsic compliance mechanism enables release of tensile stress to prevent tissue rupture
bioRxiv (2026) doi: 10.64898/2026.02.02.703250

Dey B, Kaul V, Kale G, et al.
Divergent evolutionary strategies pre-empt tissue collision in gastrulation.
Nature 646(8085), 637-646 (2025) doi: 10.1038/s41586-025-09447-4

Thukral S, Dey B, Wang Y-C.
Integrating tissue and cytoplasmic rigidity transitions during morphogenesis.
Development, Growth & Differentiation 67(7), 378-394 (2025) doi: 10.1111/dgd.70024

Gomez JM, Nolte H, Vogelsang E, et al.
Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo.
eLife 13, e99263 (2024) doi: 10.7554/eLife.99263

Wang Y-C.
The origin and the mechanism of mechanical polarity during epithelial folding.
Seminars in Cell & Developmental Biology 120, 94-107 (2021) doi: 10.1016/j.semcdb.2021.05.027

Wen F-L, Kwan CW, Wang Y-C, Shibata T.
Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.
PLOS Computational Biology 17(12), e1009614 (2021) doi: 10.1371/journal.pcbi.1009614

Eritano AS, Bromley CL, Bolea Albero A, et al.
Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding.
Developmental cell 53(2), 212-228 (2020) doi: 10.1016/j.devcel.2020.02.012

Alégot H, Markosian C, Rauskolb C, et al.
Recruitment of Jub by α-catenin promotes Yki activity and Drosophila wing growth.
Journal of Cell Science 132(5), jcs222018 (2019) doi: 10.1242/jcs.222018

Takeda M, Sami MM, Wang Y-C.
A homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shift.
Nature Cell Biology 20, 36-45. (2018) doi: 10.1038/s41556-017-0001-3

Wen F-L, Wang Y-C, Shibata T.
Epithelial folding driven by apical or basal-lateral modulation: geometric features, mechanical inference, and boundary effects.
Biophysical Journal 112, 2683-2695 (2017) doi: 10.1016/j.bpj.2017.05.012

Khan Z, Wang Y-C, Wieschaus EF, Kaschube M.
Quantitative 4D analyses of epithelial folding during Drosophila gastrulation.
Development 141(14), 2895-2900 (2014) doi: 10.1242/dev.107730

Wang Y-C, Khan Z, Wieschaus EF.
Distinct Rap1 activity states control the extent of epithelial invagination via alpha-catenin.
Developmental Cell 25, 299-309 (2013) doi: 10.1016/j.devcel.2013.04.002

Gavin-Smyth J, Wang Y-C, Butler I, Ferguson EL.
A genetic network conferring canalization to a bistable patterning system in Drosophila.
Current Biology 23(22), 2296-2302 (2013) doi: 10.1016/j.cub.2013.09.055

Wang Y-C, Khan Z, Kaschube M, Wieschaus EF.
Differential positioning of adherens junctions is associated with initiation of epithelial folding.
Nature 484, 390-3 (2012) doi: 10.1038/nature10938

Wang Y-C, Ferguson EL.
Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning.
Nature 434, 229-34 (2005) doi: 10.1038/nature03318

Podos SD, Hanson KK, Wang Y-C, Ferguson EL.
The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.
Developmental Cell 1(4), 567-578 (2001) doi: 10.1016/s1534-5807(01)00057-0

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