Publications | Laboratory for Neural Stem Cell Research

Isomura A, Asanuma D, Kageyama R.
Synchronization of the segmentation clock using synthetic cell-cell signaling.
Genes & Development 40(1-2), 124-141 (2026) doi: 10.1101/gad.352538.124

Jia X, Isomura A, Kageyama R.
Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signalling.
Development 152(17), dev204743 (2025) doi: 10.1242/dev.204743

Isomura A, Kageyama R.
Progress in understanding the vertebrate segmentation clock
Nature Reviews Genetics (2025) doi: 10.1038/s41576-025-00813-6

Shimojo H, Masaki T, Kageyama R.
The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells.
Developmental Cell 59(15), 1913-1923 (2024) doi: 10.1016/j.devcel.2024.04.019

Maeda Y, Kageyama R.
The significance of ultradian oscillations in development.
Current Opinion in Genetics & Development 86, 102180 (2024) doi: 10.1016/j.gde.2024.102180

Kaise T, Kageyama R.
Transcriptional control of neural stem cell activity.
Biochemical Society Transactions 52(2), 617-626 (2024) doi: 10.1042/BST20230439

Zhang H, Ishii K, Shibata T, et al.
Fluctuation of lysosomal protein degradation in neural stem cells of the postnatal mouse brain.
Development 151(4), dev202231 (2024) doi: 10.1242/dev.202231

Queiroz LY, Kageyama R, Cimarosti HI.
SUMOylation effects on neural stem cells self-renewal, differentiation, and survival.
Neuroscience Research 199, 1-11 (2024) doi: 10.1016/j.neures.2023.09.006

Maeda Y, Isomura A, Masaki T, Kageyama R.
Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21.
Cell Reports 42(5), 112520 (2023) doi: 10.1016/j.celrep.2023.112520

Kageyama R, Isomura A, Shimojo H.
Biological Significance of the Coupling Delay in Synchronized Oscillations.
Physiology 38(2), 0 (2023) doi: 10.1152/physiol.00023.2022

Kageyama R.
In retrospect: 25 years of the segmentation clock gene
Nature 611, 671-673 (2022) doi: 10.1038/d41586-022-03562-2

Kinoshita A, Shqirat M, Kageyama R, Ohtsuka T.
Modification of gene expression and soluble factor secretion in the lateral ventricle choroid plexus: Analysis of the impacts on the neocortical development.
Neuroscience Research 177, 38-51 (2022) doi: 10.1016/j.neures.2021.12.005

Ohtsuka T, Kageyama R.
Dual activation of Shh and Notch signaling induces dramatic enlargement of neocortical surface area.
Neuroscience Research 176, 18-30 (2022) doi: 10.1016/j.neures.2021.09.006

Umemura Y, Koike N, Tsuchiya Y, et al.
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.
Proceedings of the National Academy of Sciences of the United States of America 119(1), e2114083119 (2022) doi: 10.1073/pnas.2114083119

Kaise T, Fukui M, Sueda R, et al.
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity
Genes and Development 36, 23-37 (2022) doi: 10.1101/gad.349000.121

Harada Y, Yamada M, Imayoshi I, et al.
Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module.
Nature Communications 12(1), 6562 (2021) doi: 10.1038/s41467-021-26605-0

Sueda R, Kageyama R.
Oscillatory expression of Ascl1 in oligodendrogenesis.
Gene Expression Patterns 41, 119198 (2021) doi: 10.1016/j.gep.2021.119198

Kuriyama K, Kodama Y, Shiokawa M, et al.
Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development.
Journal of Gastroenterology 56(7), 673-687 (2021) doi: 10.1007/s00535-021-01779-y

Glaser T, Shimojo H, Ribeiro DE, et al.
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research.
Molecular Psychiatry 26(6), 2633-2650 (2021) doi: 10.1038/s41380-020-0717-5

Kaise T, Kageyama R.
Hes1 oscillation frequency correlates with activation of neural stem cells.
Gene Expression Patterns 40, 119170 (2021) doi: 10.1016/j.gep.2021.119170

Shqirat M, Kinoshita A, Kageyama R, Ohtsuka T.
Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface.
Genes to Cells 26(6), 399-410 (2021) doi: 10.1111/gtc.12847

Kobayashi T, Kageyama R.
Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells.
FEBS Journal 288(10), 3082-3093 (2021) doi: 10.1111/febs.15555

Zhang Y, Lahmann I, Baum K, et al.
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Nature Communications 12(1), 1318 (2021) doi: 10.1038/s41467-021-21631-4

Ohtsuka T, Kageyama R.
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain.
Development 148(4), dev189191 (2021) doi: 10.1242/dev.189191

Yoshioka-Kobayashi K, Kageyama R.
Imaging and manipulating the segmentation clock.
Cellular and Molecular Life Sciences 78(4), 1221-1231 (2021) doi: 10.1007/s00018-020-03655-z

Yahiro Y, Maeda S, Morikawa M, et al.
BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts.
Bone Research 8(1), 32 (2020) doi: 10.1038/s41413-020-00106-0

Kageyama R, Ochi S, Sueda R, Shimojo H.
The significance of gene expression dynamics in neural stem cell regulation.
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 96(8), 351-363 (2020) doi: 10.2183/pjab.96.026

Matsumori T, Kodama Y, Takai A, et al.
Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma.
Cancer Research 80(23), 5305-5316 (2020) doi: 10.1158/0008-5472.CAN-20-1161

Anderson MJ, Magidson V, Kageyama R, Lewandoski M.
Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function.
eLife 9, e55608 (2020) doi: 10.7554/eLife.55608

Matsuda M, Hayashi H, Garcia-Ojalvo J, et al.
Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Science 369(6510), 1450-1455 (2020) doi: 10.1126/science.aba7668

Fustin JM, Ye S, Rakers C, et al.
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans.
Communications Biology 3(1), 295 (2020) doi: 10.1038/s42003-020-1031-0

Fustin JM, Ye S, Rakers C, et al.
Methylation deficiency disrupts biological rhythms from bacteria to humans.
Communications Biology 3(1), 211 (2020) doi: 10.1038/s42003-020-0942-0

Sakamoto S, Tateya T, Omori K, Kageyama R.
Id genes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.
Developmental Biology 460(2), 164-175 (2020) doi: 10.1016/j.ydbio.2019.12.006

Yoshioka-Kobayashi K, Matsumiya M, Niino Y, et al.
Coupling delay controls synchronized oscillation in the segmentation clock.
Nature 580(7801), 119-123 (2020) doi: 10.1038/s41586-019-1882-z

Diaz-Cuadros M, Wagner DE, Budjan C, et al.
In vitro characterization of the human segmentation clock.
Nature 580(7801), 113-118 (2020) doi: 10.1038/s41586-019-1885-9

Seymour PA, Collin CA, Egeskov-Madsen AR, et al.
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.
Developmental Cell 52(6), 731-747 (2020) doi: 10.1016/j.devcel.2020.01.015

Ochi S, Imaizumi Y, Shimojo H, et al.
Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain.
Development 147(4), dev182204 (2020) doi: 10.1242/dev.182204

Imayoshi I, Tabuchi S, Matsumoto M, et al.
Light-induced silencing of neural activity in Rosa26 knock-in and BAC transgenic mice conditionally expressing the microbial halorhodopsin eNpHR3.
Scientific Reports 10(1), 3191 (2020) doi: 10.1038/s41598-020-59984-3

Bosze B, Moon MS, Kageyama R, Brown NL.
Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance.
Journal of Neuroscience 40(7), 1501-1513 (2020) doi: 10.1523/JNEUROSCI.2327-19.2020

Sueda R, Kageyama R.
Regulation of active and quiescent somatic stem cells by Notch signaling.
Development, Growth & Differentiation 62(1), 59-66 (2020) doi: 10.1111/dgd.12626

Okunomiya T, Hioki H, Nishimura C, et al.
Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling.
Genesis 58(1), e23341 (2020) doi: 10.1002/dvg.23341

Takagi A, Isomura A, Yoshioka-Kobayashi K, Kageyama R.
Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.
Gene Expression Patterns 35, 119094 (2020) doi: 10.1016/j.gep.2019.119094

Shimojo H, Kageyama R.
Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis.
Journal of Visualized Experiments (2019) doi: 10.3791/60455

Kobayashi T, Piao W, Takamura T, et al.
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells.
Nature Communications 10(1), 5446 (2019) doi: 10.1038/s41467-019-13203-4

Ohtsuka T, Kageyama R.
Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development.
Seminars in Cell & Developmental Biology 95, 4-11 (2019) doi: 10.1016/j.semcdb.2019.01.007

Tateya T, Sakamoto S, Ishidate F, et al.
Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea.
Development 146(21), dev177881 (2019) doi: 10.1242/dev.177881

Vissers C, Kageyama R.
Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.
Developmental Cell 50(4), 393-394 (2019) doi: 10.1016/j.devcel.2019.07.028

Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R.
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.
Scientific Reports 9(1), 8251 (2019) doi: 10.1038/s41598-019-44698-y

Nishikawa Y, Kodama Y, Shiokawa M, et al.
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.
Oncogene 38(22), 4283-4296 (2019) doi: 10.1038/s41388-019-0718-5

Lahmann I, Bröhl D, Zyrianova T, et al.
Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.
Genes & Development 33(9-10), 524-535 (2019) doi: 10.1101/gad.322818.118

Sueda R, Imayoshi I, Harima Y, Kageyama R.
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain.
Genes & Development 33(9-10), 511-523 (2019) doi: 10.1101/gad.323196.118

Kageyama R, Nakajima K.
Timing and shaping mechanisms of neural development.
Neuroscience Research 138, 1-2 (2019) doi: 10.1016/j.neures.2018.12.003