Team Director
Hideyuki Okano M.D., Ph.D.

Okada K, Ito D, Morimoto S, et al.
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis
Brain 147(11), 3933-3948 (2024) doi: 10.1093/brain/awae224

Morimoto S, Takahashi S, Ito D, et al.
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery
Cell Stem Cell 30(6), 766-780.e9 (2023) doi: 10.1016/j.stem.2023.04.017

Shimada H, Sato Y, Sasaki T, et al.
A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
Cell Reports Methods 2(9), 100289 (2022) doi: 10.1016/j.crmeth.2022.100289

Okano H, Morimoto S.
iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders
Cell Stem Cell 29(2), 189-208 (2022) doi: 10.1016/j.stem.2022.01.007

Heide M, Haffner C, Murayama A, et al.
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
Science 369(6503), 546-550 (2020) doi: 10.1126/science.abb2401

Fujimori K, Ishikawa M, Otomo A, et al.
Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
Nature Medicine 24(10), 1579-1589 (2018) doi: 10.1038/s41591-018-0140-5

Okano H, Sasaki E, Yamamori T, et al.
Brain/MINDS: A Japanese National Brain Project for Marmoset Neuroscience
Neuron 92(3), 582-590 (2016) doi: 10.1016/j.neuron.2016.10.018

Miura K, Okada Y, Aoi T, et al.
Variation in the safety of induced pluripotent stem cell lines
Nature Biotechnology 27(8), 743-745 (2009) doi: 10.1038/nbt.1554

Sasaki E, Suemizu H, Shimada A, et al.
Generation of transgenic non-human primates with germline transmission
Nature 459(7246), 523-527 (2009) doi: 10.1038/nature08090

Okada S, Nakamura M, Katoh H, et al.
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
Nature Medicine 12(7), 829-834 (2006) doi: 10.1038/nm1425