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研究

研究

BDRでは、様々な分野の研究者が協力して、より高い目標に向かって研究を進めています。

セミナー・シンポジウム

セミナー・イベント

BDRでは、ライフサイエンス分野の国際的な研究者を招いて、年1回のシンポジウムや定期的なセミナーを開催しています。

働く・学ぶ

働く・学ぶ

BDRでは、様々なバックグラウンドを持つ人々を受け入れ、オープンで協力的な研究環境の構築に努めています。

つながる・楽しむ

つながる・楽しむ

BDRでは、様々なメディアや活動を通じて、研究の魅力や意義を社会に発信しています。

ニュース

ニュース

最新の研究、イベント、研究者のインタビューなど、理研BDRの最新情報をお届けします。

BDRについて

BDRについて

理研の強みを生かし学際的なアプローチで生命の根源を探求し、社会の課題に応えます。

Roles of Orexin Neurons at the Interface of Systems that regulate Emotion and Arousal/Vigilance
2018年7月26日 16:00 - 17:00

カテゴリー

セミナー

場所

神戸

会場

DB Bldg. Auditorium C1F

スピーカー

Takeshi Sakurai

所属

International Institute for Integrative Sleep Medicine, University of Tsukuba

概要

Animals shift their sleep-wakefulness state according to their internal state and the external environment by utilizing three major influential elements, i.e., homeostatic, circadian and allostatic factors. Among them, allostatic factors include the nutritional state and external environment that triggers emotion. For example, stressful and emotionally-salient situations such as encountering predators, adapting to novel situations or expecting a reward require animals to shift their behavior to a vigilant state, along with alteration of their physiological condition through modulation of autonomic and endocrine functions. Studies of efferent and afferent systems of orexin-producing neurons have shown that the orexin neuronal system has close interactions with systems that are involved in the regulations of emotion, energy homeostasis, reward, and arousal. Studies by our group and others have suggested that orexin neurons are activated during the behavioural expression of fear or in response to cues associated with danger or reward. These observations suggest that orexin neurons are involved in control of vigilance states in response to outer environment. On the other hand, orexin system affects expression of behavioral response against outer environment via control of monoaminergic neurons, such as noradrenergic neurons in the locus coeruleus and serotonergic neurons in the dorsal raphe. I will discuss functional interplay between the limbic system and arousal system, and involvement of orexin and orexin receptors in these interactions.

ホスト

Masayo Takahashi

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